June 16, 2023 4 min read
One of the most important steps in the research process is formulating a research problem. It establishes the framework for the whole study and directs the researcher in determining the research’s emphasis, scope, and goals. An effective research technique may be created with the support of a clearly defined research topic, which also aids in the generation of pertinent research questions.
This article will provide a general overview of the procedure involved in defining research problems, highlighting important considerations and steps researchers should take to formulate precise and insightful research problems.
It refers to a specific topic, problem, or knowledge gap that a researcher aims to study and address through a systematic inquiry. It establishes the foundation for a research project and guides the entire investigation.
When creating a research problem, researchers often start with a topic of interest before focusing on a particular issue or question. A substantial, relevant, and original challenge adds to the corpus of knowledge and has real-world applications.
A clearly stated research topic aids in the concentration of research resources and efforts, permits the development of an effective research technique, and directs the evaluation and interpretation of data acquired. It also helps in developing research goals and hypotheses by giving the investigation a distinct direction.
For instance, a research problem could be “What are the causes leading to the decline of bee populations in urban areas?” — This study challenge addresses a particular set of urban regions and draws attention to the problem of dwindling bee numbers. By focusing on this issue, researchers may analyze the various reasons for the loss, analyze how it affects the environment, and suggest conservation tactics.
An effective research problem possesses several essential qualities that enhance its quality and suitability for examination. The key characteristics of a strong research problem are:
Should address an important issue or knowledge gap in the field of study, contributing to the existing body of knowledge.
Should be precisely stated, avoiding vague or overly general statements and providing a clear and concise description. This clarity enables the definition of research objectives and hypotheses and guides the research process.
Should be feasible in terms of the available time, resources, and skills. It can be realistically pursued, given the researcher’s capabilities and study circumstances. Sufficient data, research tools, and potential exploration paths should be reasonably accessible.
Should explore new facets, angles, or dimensions of the subject, offering fresh perspectives or approaches. This characteristic promotes intellectual progress and distinguishes the research from previous investigations.
Should be formulated in a way that allows for empirical examination and the generation of quantifiable results. Data can be systematically collected and analyzed to answer the research questions or achieve the research goals, enhancing the objectivity and rigor of the research process.
Should address relevant issues or help develop useful guidelines, regulations, or actions. It is more effective when it impacts multiple stakeholders and has the potential to produce practical results.
Should be intellectually engaging and interesting to the researcher and the academic community. It sparks curiosity and encourages further research, leading to high-quality research output.
Should adhere to ethical principles and rules, considering the welfare and rights of participants or subjects involved in the study.
Types of research problems.
Research problems can be categorized into different types based on their nature and scope. The three most common types are:
It involves using theoretical frameworks, concepts, and models to investigate a subject or event. Theoretical research aims to extend existing knowledge, address unsolved disputes or gaps, or critique and evaluate preexisting theories.
It focuses on specific problems or challenges within a particular industry or sector and aims to provide practical solutions through systematic research. Applied research aims to bridge the gap between theory and practical application, optimizing existing processes, technologies, products, or services.
Action research combines research and action to address real-world issues. It encompasses problem-solving in various contexts, such as organizations, education, community development, policy implementation, and personal or professional development. Action research is flexible and can be tailored to different situations and issues.
Research problems play a vital role in shaping the direction and course of an investigation. They serve as the foundation for the entire research process, guiding researchers in their pursuit of knowledge and advancement in a specific field. The importance of research problems lies in the following:
Research problems help identify areas where knowledge is lacking or incomplete, highlighting the need for further investigation and addressing unanswered questions.
A well-defined research problem gives the research project focus and direction. It aids in the development of an effective research design, technique and the establishment of research objectives and questions.
A clear research problem helps researchers justify the value and importance of their study by emphasizing its relevance, potential benefits, and contributions to the field.
Research problems often stem from real-world challenges or problems. By examining these problems, researchers can develop innovative ideas, methods, or strategies to solve practical issues or guide decision-making.
Research problems serve as a basis for developing new concepts, hypotheses, or models. By addressing research challenges, researchers contribute to understanding a subject, debunk preexisting beliefs, or propose new hypotheses.
Research problems encourage intellectual curiosity and innovation by pushing researchers to explore fresh perspectives and methodologies. By encouraging critical thinking, generating original ideas, and developing unique research approaches, research problems foster innovation and creativity.
5 steps to formulate research problems.
Formulating research problems is a crucial initial step in conducting purposeful and targeted research. Here are five steps to follow:
Determine the broad subject or field that interests you, considering discipline-specific topics or specific phenomena.
Review existing literature and research in your chosen field to understand the current knowledge level and identify gaps or unsolved issues and areas requiring further research. Read relevant scholarly publications, books, and articles to gain a comprehensive understanding.
Based on the literature review, select a specific component or subject within your chosen research field. Look for inconsistencies, contradictions, or open-ended questions in the existing literature that can present challenges for future research. Refine your research topic and focus it on a single problem or phenomenon.
Establish clear and concise research objectives that outline your investigation’s specific aims or outcomes. SMART (specific, measurable, attainable, relevant, and time-bound) objectives help maintain focus and guide the research process effectively.
Create distinct research questions or hypotheses that align with your research problem and objectives. Qualitative research often utilizes research questions, while quantitative research employs hypotheses. Ensure these inquiries or hypotheses are precise, concise, and aimed at addressing the stated research problem.
Remember that formulating research problems is an iterative process. As you learn more about the topic and develop new ideas, it can need several changes and improvements. You may establish a solid basis for your study and improve your chances of performing fruitful and influential research by adhering to these recommendations and continually improving your research problem.
Researchers can create precise and insightful research problems that add to the body of knowledge and progress in their particular fields of study by using the procedures described in this article. A research problem outlines the precise field of inquiry and knowledge gaps that the research attempts to address, defining the scope and objective of a study.
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Published on October 26, 2022 by Shona McCombes . Revised on November 21, 2023.
A research question pinpoints exactly what you want to find out in your work. A good research question is essential to guide your research paper , dissertation , or thesis .
All research questions should be:
How to write a research question, what makes a strong research question, using sub-questions to strengthen your main research question, research questions quiz, other interesting articles, frequently asked questions about research questions.
You can follow these steps to develop a strong research question:
The way you frame your question depends on what your research aims to achieve. The table below shows some examples of how you might formulate questions for different purposes.
Research question formulations | |
---|---|
Describing and exploring | |
Explaining and testing | |
Evaluating and acting | is X |
Example research problem | Example research question(s) |
---|---|
Teachers at the school do not have the skills to recognize or properly guide gifted children in the classroom. | What practical techniques can teachers use to better identify and guide gifted children? |
Young people increasingly engage in the “gig economy,” rather than traditional full-time employment. However, it is unclear why they choose to do so. | What are the main factors influencing young people’s decisions to engage in the gig economy? |
Note that while most research questions can be answered with various types of research , the way you frame your question should help determine your choices.
Professional editors proofread and edit your paper by focusing on:
See an example
Research questions anchor your whole project, so it’s important to spend some time refining them. The criteria below can help you evaluate the strength of your research question.
Criteria | Explanation |
---|---|
Focused on a single topic | Your central research question should work together with your research problem to keep your work focused. If you have multiple questions, they should all clearly tie back to your central aim. |
Answerable using | Your question must be answerable using and/or , or by reading scholarly sources on the to develop your argument. If such data is impossible to access, you likely need to rethink your question. |
Not based on value judgements | Avoid subjective words like , , and . These do not give clear criteria for answering the question. |
Criteria | Explanation |
---|---|
Answerable within practical constraints | Make sure you have enough time and resources to do all research required to answer your question. If it seems you will not be able to gain access to the data you need, consider narrowing down your question to be more specific. |
Uses specific, well-defined concepts | All the terms you use in the research question should have clear meanings. Avoid vague language, jargon, and too-broad ideas. |
Does not demand a conclusive solution, policy, or course of action | Research is about informing, not instructing. Even if your project is focused on a practical problem, it should aim to improve understanding rather than demand a ready-made solution. If ready-made solutions are necessary, consider conducting instead. Action research is a research method that aims to simultaneously investigate an issue as it is solved. In other words, as its name suggests, action research conducts research and takes action at the same time. |
Criteria | Explanation |
---|---|
Cannot be answered with or | Closed-ended, / questions are too simple to work as good research questions—they don’t provide enough for robust investigation and discussion. |
Cannot be answered with easily-found facts | If you can answer the question through a single Google search, book, or article, it is probably not complex enough. A good research question requires original data, synthesis of multiple sources, and original interpretation and argumentation prior to providing an answer. |
Criteria | Explanation |
---|---|
Addresses a relevant problem | Your research question should be developed based on initial reading around your . It should focus on addressing a problem or gap in the existing knowledge in your field or discipline. |
Contributes to a timely social or academic debate | The question should aim to contribute to an existing and current debate in your field or in society at large. It should produce knowledge that future researchers or practitioners can later build on. |
Has not already been answered | You don’t have to ask something that nobody has ever thought of before, but your question should have some aspect of originality. For example, you can focus on a specific location, or explore a new angle. |
Chances are that your main research question likely can’t be answered all at once. That’s why sub-questions are important: they allow you to answer your main question in a step-by-step manner.
Good sub-questions should be:
Here are a few examples of descriptive and framing questions:
Keep in mind that sub-questions are by no means mandatory. They should only be asked if you need the findings to answer your main question. If your main question is simple enough to stand on its own, it’s okay to skip the sub-question part. As a rule of thumb, the more complex your subject, the more sub-questions you’ll need.
Try to limit yourself to 4 or 5 sub-questions, maximum. If you feel you need more than this, it may be indication that your main research question is not sufficiently specific. In this case, it’s is better to revisit your problem statement and try to tighten your main question up.
If you want to know more about the research process , methodology , research bias , or statistics , make sure to check out some of our other articles with explanations and examples.
Methodology
Statistics
Research bias
The way you present your research problem in your introduction varies depending on the nature of your research paper . A research paper that presents a sustained argument will usually encapsulate this argument in a thesis statement .
A research paper designed to present the results of empirical research tends to present a research question that it seeks to answer. It may also include a hypothesis —a prediction that will be confirmed or disproved by your research.
As you cannot possibly read every source related to your topic, it’s important to evaluate sources to assess their relevance. Use preliminary evaluation to determine whether a source is worth examining in more depth.
This involves:
A research hypothesis is your proposed answer to your research question. The research hypothesis usually includes an explanation (“ x affects y because …”).
A statistical hypothesis, on the other hand, is a mathematical statement about a population parameter. Statistical hypotheses always come in pairs: the null and alternative hypotheses . In a well-designed study , the statistical hypotheses correspond logically to the research hypothesis.
Formulating a main research question can be a difficult task. Overall, your question should contribute to solving the problem that you have defined in your problem statement .
However, it should also fulfill criteria in three main areas:
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For some students, choosing a topic for their dissertation comes organically, or it may have even been part of the reason they pursued their PhD in the first place. However, for others, it can be a bit more of a struggle. This can be for a number of reasons. Perhaps you had something in mind at your workplace, but then changed jobs so the population of interest is no longer available for you to sample. Perhaps you discover that a study you had your heart set on involves a vulnerable population and, as a result, the IRB has denied your request to do this study (yes, they can and will do that in certain circumstances).
In order to discover a study topic that is not only feasible but also reasonable, justifiable, and necessary, you may find it helpful to ask yourself the following questions:
What is the specific problem? This pertains more to being able to identify the variables of you chosen topic so that you can devise research questions. This is also an important moment to pause and dig through the literature to ensure that you can identify support for the existence of this problem as a gap in the literature with other (recent) research studies.
What theory can I use to explore this study? Whether you choose to do a qualitative or quantitative study, you will need a theory to ground it.
What methodological approach can I use? Is there an instrument out there that is valid and reliable that you can use to assess your variables? If not, and you are studying perceptions or lived experiences, you may have a qualitative study on your hands.
Who is going to participate in this study? And, more importantly, how will you access them? Can you access them?
Once you are in a place where you can confidently and completely answer each of these questions, you have a solid, defendable dissertation topic. Congrats! Now, you just need to figure out your title – in 12 words or less. Good luck!
We work with graduate students every day and know what it takes to get your research approved.
Q1. Which of the following statement is correct? (A) Reliability ensures the validity (B) Validity ensures reliability (C) Reliability and validity are independent of each other (D) Reliability does not depend on objectivity
Answer: (C)
Q2. Which of the following statements is correct? (A) Objectives of research are stated in first chapter of the thesis (B) Researcher must possess analytical ability (C) Variability is the source of problem (D) All the above
Answer: (D)
Q3. The first step of research is: (A) Selecting a problem (B) Searching a problem (C) Finding a problem (D) Identifying a problem
Q4. Research can be conducted by a person who: (A) holds a postgraduate degree (B) has studied research methodology (C) possesses thinking and reasoning ability (D) is a hard worker
Answer: (B)
Q5. Research can be classified as: (A) Basic, Applied and Action Research (B) Philosophical, Historical, Survey and Experimental Research (C) Quantitative and Qualitative Research (D) All the above
Q6. To test null hypothesis, a researcher uses: (A) t test (B) ANOVA (C) X 2 (D) factorial analysis
Answer: (B)
Q7. Bibliography given in a research report: (A) shows vast knowledge of the researcher (B) helps those interested in further research (C) has no relevance to research (D) all the above
Q8. A research problem is feasible only when: (A) it has utility and relevance (B) it is researchable (C) it is new and adds something to knowledge (D) all the above
Q9. The study in which the investigators attempt to trace an effect is known as: (A) Survey Research (B) Summative Research (C) Historical Research (D) ‘Ex-post Facto’ Research
Answer: (D)
Q10. Generalized conclusion on the basis of a sample is technically known as: (A) Data analysis and interpretation (B) Parameter inference (C) Statistical inference (D) All of the above
Answer: (A)
Q11. Fundamental research reflects the ability to: (A) Synthesize new ideals (B) Expound new principles (C) Evaluate the existing material concerning research (D) Study the existing literature regarding various topics
Q12. The main characteristic of scientific research is: (A) empirical (B) theoretical (C) experimental (D) all of the above
Q13. Authenticity of a research finding is its: (A) Originality (B) Validity (C) Objectivity (D) All of the above
Q14. Which technique is generally followed when the population is finite? (A) Area Sampling Technique (B) Purposive Sampling Technique (C) Systematic Sampling Technique (D) None of the above
Q15. Research problem is selected from the stand point of: (A) Researcher’s interest (B) Financial support (C) Social relevance (D) Availability of relevant literature
Q16. The research is always – (A) verifying the old knowledge (B) exploring new knowledge (C) filling the gap between knowledge (D) all of these
Q17. Research is (A) Searching again and again (B) Finding a solution to any problem (C) Working in a scientific way to search for the truth of any problem (D) None of the above
Q20. A common test in research demands much priority on (A) Reliability (B) Useability (C) Objectivity (D) All of the above
Q21. Which of the following is the first step in starting the research process? (A) Searching sources of information to locate the problem. (B) Survey of related literature (C) Identification of the problem (D) Searching for solutions to the problem
Answer: (C)
Q22. Which correlation coefficient best explains the relationship between creativity and intelligence? (A) 1.00 (B) 0.6 (C) 0.5 (D) 0.3
Q23. Manipulation is always a part of (A) Historical research (B) Fundamental research (C) Descriptive research (D) Experimental research
Explanation: In experimental research, researchers deliberately manipulate one or more independent variables to observe their effects on dependent variables. The goal is to establish cause-and-effect relationships and test hypotheses. This type of research often involves control groups and random assignment to ensure the validity of the findings. Manipulation is an essential aspect of experimental research to assess the impact of specific variables and draw conclusions about their influence on the outcome.
Q24. The research which is exploring new facts through the study of the past is called (A) Philosophical research (B) Historical research (C) Mythological research (D) Content analysis
Q25. A null hypothesis is (A) when there is no difference between the variables (B) the same as research hypothesis (C) subjective in nature (D) when there is difference between the variables
Q26. We use Factorial Analysis: (A) To know the relationship between two variables (B) To test the Hypothesis (C) To know the difference between two variables (D) To know the difference among the many variables
Explanation: Factorial analysis, specifically factorial analysis of variance (ANOVA), is used to investigate the effects of two or more independent variables on a dependent variable. It helps to determine whether there are significant differences or interactions among the independent variables and their combined effects on the dependent variable.
Q27. Which of the following is classified in the category of the developmental research? (A) Philosophical research (B) Action research (C) Descriptive research (D) All the above
Q28. Action-research is: (A) An applied research (B) A research carried out to solve immediate problems (C) A longitudinal research (D) All the above
Explanation: Action research is an approach to research that encompasses all the options mentioned. It is an applied research method where researchers work collaboratively with practitioners or stakeholders to address immediate problems or issues in a real-world context. It is often conducted over a period of time, making it a longitudinal research approach. So, all the options (A) An applied research, (B) A research carried out to solve immediate problems, and (C) A longitudinal research are correct when describing action research.
Q29. The basis on which assumptions are formulated: (A) Cultural background of the country (B) Universities (C) Specific characteristics of the castes (D) All of these
Q30. How can the objectivity of the research be enhanced? (A) Through its impartiality (B) Through its reliability (C) Through its validity (D) All of these
Q31. A research problem is not feasible only when: (A) it is researchable (B) it is new and adds something to the knowledge (C) it consists of independent and dependent var i ables (D) it has utility and relevance
Explanation: A research problem is considered feasible when it can be studied and investigated using appropriate research methods and resources. The presence of independent and dependent variables is not a factor that determines the feasibility of a research problem. Instead, it is an essential component of a well-defined research problem that helps in formulating research questions or hypotheses. Feasibility depends on whether the research problem can be addressed and answered within the constraints of available time, resources, and methods. Options (A), (B), and (D) are more relevant to the feasibility of a research problem.
Q32. The process not needed in experimental research is: (A) Observation (B) Manipulation and replication (C) Controlling (D) Reference collection
In experimental research, reference collection is not a part of the process.
Q33. When a research problem is related to heterogeneous population, the most suitable sampling method is: (A) Cluster Sampling (B) Stratified Sampling (C) Convenient Sampling (D) Lottery Method
Explanation: When a research problem involves a heterogeneous population, stratified sampling is the most suitable sampling method. Stratified sampling involves dividing the population into subgroups or strata based on certain characteristics or variables. Each stratum represents a relatively homogeneous subset of the population. Then, a random sample is taken from each stratum in proportion to its size or importance in the population. This method ensures that the sample is representative of the diversity present in the population and allows for more precise estimates of population parameters for each subgroup.
Q34. Generalised conclusion on the basis of a sample is technically known as: (A) Data analysis and interpretation (B) Parameter inference (C) Statistical inference (D) All of the above
Explanation: Generalized conclusions based on a sample are achieved through statistical inference. It involves using sample data to make inferences or predictions about a larger population. Statistical inference helps researchers draw conclusions, estimate parameters, and test hypotheses about the population from which the sample was taken. It is a fundamental concept in statistics and plays a crucial role in various fields, including research, data analysis, and decision-making.
Q35. The experimental study is based on
(A) The manipulation of variables (B) Conceptual parameters (C) Replication of research (D) Survey of literature
Q36. Which one is called non-probability sampling? (A) Cluster sampling (B) Quota sampling (C) Systematic sampling (D) Stratified random sampling
Q37. Formulation of hypothesis may NOT be required in: (A) Survey method (B) Historical studies (C) Experimental studies (D) Normative studies
Q38. Field-work-based research is classified as: (A) Empirical (B) Historical (C) Experimental (D) Biographical
Q39. Which of the following sampling method is appropriate to study the prevalence of AIDS amongst male and female in India in 1976, 1986, 1996 and 2006? (A) Cluster sampling (B) Systematic sampling (C) Quota sampling (D) Stratified random sampling
Q40. The research that applies the laws at the time of field study to draw more and more clear ideas about the problem is: (A) Applied research (B) Action research (C) Experimental research (D) None of these
Answer: (A)
A. It is researchable
B. It is new and adds something to knowledge
C. It has utility and relevance
D. All of these
Answer: Option D
This Question Belongs to General Knowledge >> Teaching And Research
Related Questions on Teaching and Research
Most important work of teacher is
A. To organize teaching work
B. To deliver lecture in class
C. To take care of children
D. To evaluate the students
A teacher should be
B. Diligent
D. Punctual
Environmental education should be taught in schools because
A. It will affect environmental pollution
B. It is important part of life
C. It will provide job to teachers
D. We cannot escape from environment
At primary level, it is better to teach in mother language because
A. It develops self-confidence in children
B. It makes learning easy
C. It is helpful in intellectual development
D. It helps children in learning in natural atmosphere
More Related Questions on Teaching and Research
A research problem is feasible only when
Right answer is: all of the above.
A research problem can be defined as a statement about the area of interest, a condition that is required to be improved, a difficulty that has to be eradicated, or any disquieting question existing in scholarly literature, in theory, or in practice that points to be solved.
Set-I (Research Methods) | Set-II (Data Collection Tools) |
a. Experimental method | I. Using primary and secondary source |
b. Ex post-facto method | ii. Questionsnaire |
c. Descriptive survey method | iii. Standardized tests |
d. Historical method | iv. Typical characteristic tests |
List-A | List-B |
(a) Survey Method | (i) Past events |
(b) Historical Method | (ii) Vision |
(c) Philosophical Method | (iii) Present events |
(d) Experimental Method | (iv) Exceptional cases |
(v) Future action |
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Medical research has shortchanged women for decades. This is particularly true of older women, leaving them without critically important information.
Many drugs widely prescribed to older adults were studied mostly in men, with results extrapolated to women. Consider the Alzheimer’s drug Leqembi, approved by the FDA last year after the manufacturer reported a 27% slower rate of cognitive decline in people who took the medication. A study in the New England Journal of Medicine revealed that sex differences were substantial: a 12% slowdown for women, compared with a 43% slowdown for men. And nearly two-thirds of older adults with Alzheimer’s are women.
“It’s assumed that women’s biology doesn’t matter and that women who are premenopausal and those who are postmenopausal respond similarly,” said Stephanie Faubion, director of the Mayo Clinic’s Center for Women’s Health. “This has got to stop.”
Older women are also more likely than older men to have multiple medical conditions, disabilities, difficulties with daily activities, autoimmune illness, depression and anxiety, uncontrolled high blood pressure and osteoarthritis, among other issues, according to scores of research studies.
Even so, women outlive men by more than five years in the U.S. Which means that older women outnumber older men by significant margins. If we’re concerned about the health of the older population, we need to be concerned about the health of older women.
Late last year, the Biden administration promised to address this problem with the new White House Initiative on Women’s Health Research . Which raises the question: What priorities should be on its list for older women?
Here’s what doctors and researchers suggested.
Women with heart disease, which becomes far more common after menopause and kills more women than any other condition, are given less care.
“We’re notably less aggressive,” said Martha Gulati, associate director of the Barbra Streisand Women’s Heart Center at Cedars-Sinai in Los Angeles. “We delay evaluations for chest pain. We don’t give blood thinners at the same rate. We don’t do procedures like aortic valve replacements as often. We’re not adequately addressing hypertension. We need to figure out why these biases in care exist and how to remove them.”
Older women are less likely than their male peers to have obstructive coronary artery disease and undetected damage to smaller blood vessels, Gulati said. When they get procedures such as cardiac catheterizations, women have more bleeding and complications.
What are the best treatments for older women given these issues? “We have very limited data. This needs to be a focus,” Gulati said.
How can women reduce their risk of cognitive decline and dementia as they age? “We really need to have clear messages for women and effective interventions that are feasible and accessible,” said JoAnn Manson, a key researcher for the Women’s Health Initiative , the largest study of women’s health in the U.S.
Numerous factors affect women’s brain health, including stress – sexism, caregiving responsibilities and financial strain. Older women lose estrogen, a hormone important to brain health. They have a higher incidence of conditions with serious brain impacts such as multiple sclerosis and stroke.
Older women are also more vulnerable to anxiety and depression. Studies suggest a variety of factors, including hormonal changes and cumulative stress. Paula Rochon, a professor of geriatrics at the University of Toronto, also faulted “gendered ageism” in an interview in Nature Aging.
Helen Lavretsky, past president of the American Association for Geriatric Psychiatry, named several topics that need further investigation. How does menopause impact mood and stress-related disorders? What nonpharmaceutical interventions can promote resilience in older women and help them recover? What combination of interventions is likely to be most effective?
Supriya Gupta Mohile, director of the Geriatric Oncology Research Group at the University of Rochester, wants better guidance about breast cancer screening for older women.
“Right now, I think we’re underscreening fit older women and overscreening frail older women,” Mohile said.
The doctor also wants more research about effective, safe and tolerable treatments for lung cancer in older women, many of whom have multiple medical conditions and functional impairments. The age-sensitive condition kills more women than breast cancer.
Osteoporosis is more common in older women than older men, increasing the risk of dangerous fractures and falls.
Jane Cauley, a professor at the University of Pittsburgh, wants more data about the condition among older Black, Asian and Hispanic women, who are undertreated. She also wants better drugs with fewer side effects.
Marcia Stefanick, a professor at Stanford University School of Medicine, wants to know which strategies are most likely to motivate older women to be physically active. And she’d like more studies investigating how older women can best preserve muscle mass, strength and the ability to care for themselves.
“Frailty is one of the biggest problems for older women,” she said. “Learning what can be done to prevent that is essential.”
KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF – an independent source of health policy research, polling and journalism.
Making a change would be far from easy, despite concerns about President Biden’s debate performance. But here’s who has surfaced before — and could again.
The Democratic Party has spent much of the 2024 campaign burying its head in the sand over Americans’ concerns about President Biden’s age and mental sharpness. Rather than reckon with the problem, its most influential voices have cast it as an overblown media construct.
But the party abruptly jerked its head out of that sand Thursday night, after a meandering, occasionally incoherent and almost universally panned first-debate performance from Biden . At its most pronounced, this has led to calls for Biden to step aside, including from those loyal to him.
That instantaneous reaction is hugely significant, in and of itself. It’s the kind of conversation you avoid — and the party has strained to avoid — until you view it as absolutely necessary. Going there and then having Biden stay would only damage him further, because a bunch of allies would have said either implicitly or explicitly that he is not up to the task.
It’s truly a desperate plan and one that features many hurdles . It would almost surely require Biden’s assent to step aside — he holds almost all of the pledged delegates to August’s Democratic National Convention — and even then the process for replacing him is fraught . It’s not even clear that an alternative would render the party better off.
But it’s a prospect that the party has given some consideration, dating back to when Biden had yet to announce his reelection campaign last year. Names were floated as alternatives or even primary challengers.
So, should the party go this route, who would even make sense? Let’s recap some of the names that have been floated — along with their attributes and drawbacks.
It’s difficult to see how Harris wouldn’t be the alternative unless she, too, voluntarily steps aside. She is, after all, the vice president. And skipping over the first female and first Black vice president would be dicey for a party struggling to maintain its normally huge margins with Black voters — a major part of its base.
The problem is that Harris is about as unpopular as Biden is. Recent surveys from Monmouth University and Suffolk University have shown disapproval of her outpacing approval by 18 and 16 points , respectively. Harris’s own 2020 presidential campaign went poorly, and the party would have little faith that she would be a marked improvement over Biden.
Republicans have made little secret that they relish elevating Harris, with the Trump campaign even running an ad during Thursday’s debate pointing to the possibility that Harris would have to replace Biden as president at some point.
This is a name you’re likely to see plenty in the days ahead. The Michigan governor combines being an actually plausible alternative with looking almost ideal on paper.
She’s a female governor who hails from a crucial state (Democrats need to hold Midwestern swing states , given their problems in other swing states). She has won both of her races there by around 10 points. Polling this year has shown her approval rating in Michigan between 54 percent and 61 percent . And she’s more experienced and has more of a national profile than a lot of other rising-star Democratic governors, such as Pennsylvania Gov. Josh Shapiro and Maryland Gov. Wes Moore.
After Harris, she would quickly rise to the top.
It’s perhaps an undersold fact that the transportation secretary nearly won both the Iowa and New Hampshire presidential nominating contests back in 2020 when he was just a mayor of a midsize Midwestern city (South Bend, Ind.). And if the party is looking for the antithesis of Biden’s inability to drive a message against Trump, it’s Buttigieg. His jousting with Fox News hosts and Republicans at congressional hearings is often shared widely in Democratic circles. He’s a gifted messenger.
If there’s a big drawback with Buttigieg, it’s that he appears to be the wrong candidate to try to arrest the Democratic ticket’s apparent problem with diverse — and especially Black — voters. He got very little support from such groups in 2020.
The Pennsylvania governor is one of the more intriguing rising stars in the national Democratic Party, earning plaudits for his big 2022 win and bipartisan credentials . He’s also, like Whitmer, quite popular in a crucial state for the Democratic ticket. Even more than 3 in 10 Trump supporters there like him , according to a poll this year. It’s hard to see how that doesn’t catch Democrats’ eye.
But Shapiro has largely been regarded as an option for 2028, having been governor for just a year and a half. He’s been in statewide office for a while, having previously served as state attorney general, but it would be a rapid rise.
The Colorado governor and former congressman has some of the same bipartisan bona fides as Shapiro. The nation’s first openly gay man to be elected governor has crafted a compelling record and has largely avoided getting bogged down in potentially problematic liberal policies. He has also won big — by double digits in 2018 and nearly 20 points in 2022.
And he has clearly expressed interest in going national one day .
Perhaps nobody has surfaced more as an alternative should Biden step aside than the California governor, owing in large part to his efforts to expand his national profile by mixing it up with national Republicans and GOP governors. On that front, Newsom would seem to have some of the same attributes as Buttigieg.
But it’s difficult to see the Democratic Party deciding that the recipe right now is a California governor and former mayor of San Francisco, a city Republicans would be only so happy to run against by pointing to its crime problem. It would be basically inviting Republicans to caricature the Democratic ticket.
The Georgia senator has won a key swing state twice now in a short time. And his stock would seem to be higher than that of other Black candidates who have graced lists like this in the past, such as Sen. Cory Booker (D-N.J.).
Warnock’s 2022 campaign, in particular, was seen as a road map for how Democrats could run in 2024. And with Democrats struggling to keep swing states outside the Midwest in play, picking someone who hails from one of them makes a lot of sense.
This is the fantasy option for Democrats — and we mean that in more than one way. She would seem to be the ideal alternative for many, but she also seems unlikely to run.
Obama is the most popular former first lady in America, dating back to Lady Bird Johnson, according to a late-2023 YouGov poll. She has also consistently been liked by a clear majority of Americans, which we can’t say for many political figures.
But she has professed basically no interest in running in her own right; going from that to waging a presidential campaign with just a few months to go is a huge stretch. We also learned this week about reported tensions between her and the Biden campaign .
It’s truly a break-glass-in-case-of-emergency option. And the glass appears to be shatterproof.
The Minnesota senator would make the most sense if Democrats sought a candidate with many of the same attributes Biden has, minus the age problem. She is pragmatic and seemingly broadly agreeable. She has a strong electoral track record in her state.
But she still cuts a very limited national profile, and her 2020 presidential campaign didn’t gain much traction. If the name of the game is picking someone to take the fight to Trump, Minnesota Nice might not be the recipe.
Perhaps nobody’s stock has risen more in recent months. That owes to the fact that the Kentucky governor was up for reelection in 2023 and won in a very red state.
He has intriguing bipartisan appeal, and he has succeeded in his state without straying too much to the right. (We often see that Democratic governors in red states and GOP governors in blue states have to take positions that don’t comport with their national party.) He even played up his support for abortion rights during the 2023 campaign — something previously unthinkable.
He also reportedly is taking the kind of steps you would expect from someone with national ambitions . But it’s not clear how he would play with liberal base voters whom Democrats need to inject with enthusiasm.
Get the latest news on the 2024 election from our reporters on the campaign trail and in Washington.
The first presidential debate: President Biden and Donald Trump faced off in the first presidential debate of 2024. Here are takeaways and fact checks from the debate .
Key dates and events: Voters in all states and U.S. territories have been choosing their party’s nominee for president ahead of the summer conventions. Here are key dates and events on the 2024 election calendar .
Abortion and the election: Voters in about a dozen states could decide the fate of abortion rights with constitutional amendments on the ballot in a pivotal election year. Biden supports legal access to abortion , and he has encouraged Congress to pass a law that would codify abortion rights nationwide. After months of mixed signals about his position, Trump said the issue should be left to states . Here’s how Biden’s and Trump’s abortion stances have shifted over the years.
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Reporting by Jeff Mason; Additional reporting by Stephanie Kelly; Editing by Heather Timmons and Sandra Maler
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Jeff Mason is a White House Correspondent for Reuters. He has covered the presidencies of Barack Obama, Donald Trump and Joe Biden and the presidential campaigns of Biden, Trump, Obama, Hillary Clinton and John McCain. He served as president of the White House Correspondents’ Association in 2016-2017, leading the press corps in advocating for press freedom in the early days of the Trump administration. His and the WHCA's work was recognized with Deutsche Welle's "Freedom of Speech Award." Jeff has asked pointed questions of domestic and foreign leaders, including Russian President Vladimir Putin and North Korea's Kim Jong Un. He is a winner of the WHCA's “Excellence in Presidential News Coverage Under Deadline Pressure" award and co-winner of the Association for Business Journalists' "Breaking News" award. Jeff began his career in Frankfurt, Germany as a business reporter before being posted to Brussels, Belgium, where he covered the European Union. Jeff appears regularly on television and radio and teaches political journalism at Georgetown University. He is a graduate of Northwestern University's Medill School of Journalism and a former Fulbright scholar.
The United States will soon announce more than $2.3 billion in new security assistance for Ukraine, U.S. Defense Secretary Lloyd Austin said on Tuesday during a meeting with his Ukrainian counterpart at the Pentagon.
Welcome to the Money blog, your place for personal finance and consumer news and tips. Leave a comment on any of the stories we're covering below.
Tuesday 2 July 2024 15:17, UK
A free streaming service to rival the likes of Netflix, Amazon Prime and Disney+ is being launched in the UK by Rupert Murdoch's Fox Corporation.
The service called Tubi will be funded by advertising and provide personalised streaming.
It already operates in North America where Fox said it has attracted 80 million active users.
More than 20,000 films and TV episodes will be on offer, Fox said, "one of the largest and most diverse content libraries in the UK".
While no specific titles were listed Fox said users can expect blockbusters, original stories and hidden gems.
Is it any good?
It depends who you ask.
It has a pretty bad 2.3 score on Trustpilot - but it's a relatively small sample at 66 reviews.
A PC Mag review was way more positive - rating it "excellent" with four stars out of five.
They said: "Tubi is a free, ad-supported video streaming service that features a delightfully large and frequently updated library of movies and shows. There's no reason not to give it a try."
Drawbacks were said to include no ad-free options and the 720p streaming resolution cap.
Why is it coming to UK?
Business presenter Ian King has been looking at this today.
He says: "Tubi's entry to the UK market has got some scratching their heads.
"Not only is the market seemingly saturated but production costs are rising, obliging the streamers to either raise subscription fees or rely on an increasingly smaller pool of advertisers.
"But rivals would do well to take the new competitor seriously and not least because Tubi has already, in the US, shown a clean pair of heels to many of the businesses it will be competing with here."
Read King's full analysis here ...
Wimbledon is in full swing (sorry!) and the world's best tennis players are battling it out on the famous grass courts in the hopes of being presented with the trophy in under two weeks' time.
But it's not just pride that comes with winning - there's a fairly decent prize fund as well.
This year, the prize for winning the singles is a huge £2.7m - up by an inflation-busting 15% compared with £2.35m in 2023. The prize money is the same for both sexes and has been since the rules changed in 2007.
Players don't have to win the championship to get their hands on some cash though, as there's also a prize fund for getting through each stage of the competition.
Here's a breakdown for the singles championship:
Meanwhile, the prize for winning the doubles is £650,000, with runners up getting £330,000. For mixed doubles, it's £130,000 and £65,000 respectively.
Players taking part in wheelchair singles have the chance to nab £65,000 for winning.
Overall, the total prize money on offer across all championships is a whopping £50m - up 12% from last year.
Food inflation has fallen to its lowest level since 2021, new figures show.
New data from the British Retail Consortium (BRC)-NielsenIQ Shop Price Index reveals that food prices in June were 2.5% higher than a year ago.
This was down from 3.2% in May, and marked the fourteenth consecutive slowing of food inflation.
It means the rate is now lower than at any point since December 2021, with the drop fuelled by tumbling prices for staple products such as butter and coffee.
Inflation on fresh food slowed to 1.5%, down from 2% in May, while overall shop price inflation fell to 0.2% - the lowest level since October 2021.
BRC chief executive Helen Dickinson said the winner of Thursday's general election "will benefit from the work of retailers to cut their costs and prices, easing the cost of living for millions of households".
In the eastern Aegean, the islands of Chios and Kos experienced dangerous fires yesterday - with blazes raging on Kos for a second day today amid tinderbox conditions and unusually strong winds.
The Greek prime minister has warned his country faces another dangerous summer for wildfires.
Beyond the human tragedy these blazes can cause, there's a knock-on effect on tourism in the country.
So what are your rights if your holiday is disrupted by the fires? We've got a quick explainer here…
What if I have a package holiday and face cancellation or disruption?
The Foreign Office is not currently advising against travel to Greece, and with the majority of the country and its surrounding islands unaffected, holidays are still going ahead.
But holiday operators do have the right to cancel holidays for situations out of their control.
If the company you booked your package holiday with cancels your trip, the Competition and Markets Authority says customers are entitled to a refund within 14 days of the cancellation date.
Alternatively, they should be offered a replacement holiday of the same or better quality, or a lower-grade holiday with a partial refund.
If something goes wrong while you're away on a package holiday, Citizens Advice recommends getting in touch with the company or travel agent you booked with as soon as possible.
The Association of British Insurers (ABI) advised package holiday customers during last year's wildfires they may be entitled to a partial refund for a trip cut short due to wildfires, depending on several factors including what services were included and how much of the holiday had already been taken.
Will my insurance cover any issues?
This depends on a few things - including when you took out the policy, who you took it out with and what the exact terms and conditions are.
If your policy includes trip disruption or natural disaster cover, you should be covered if you have to cut short or cancel your holiday due to wildfires, according to the ABI.
Natural disaster cover isn't included in every policy, so read the T&Cs carefully.
You're unlikely to be covered if you took out the policy or booked the trip to a specific area affected by wildfires after they were known about. You also won't be covered if you travel against Foreign Office advice.
If you have booked a package holiday with an operator and it comes with an Atol certificate, you'll have extra protections, although you'll still need insurance for health and accident cover.
If you've booked the separate parts of your trip yourself, you're more reliant on insurance and will need to make sure you've got a policy in place that would cover you for wildfires and other natural disasters such as floods and storms.
What are my rights if my flight is cancelled?
Your flight is covered by UK law if it departs from a UK airport, arrives at a UK airport on a UK or EU airline, or arrives at an EU airport on a UK airline.
Under UK law, if your flight is cancelled the airline must either give you a refund or book you on an alternative flight - either with them or a rival airline.
Each airline will have its own cancellation policy for customers.
If your flight is cancelled within 14 days of travel - and you can prove it was the airline's fault - you are entitled to compensation. However, extreme weather and other "extraordinary circumstances" mean the airline can get out of paying.
And if I cancel the holiday myself?
If the Foreign Office doesn't advise against travel to a wildfire-affected country or area then under normal booking conditions, you'd be ineligible for a refund.
However, you could speak to your travel agent or holiday company if you're particularly concerned. They may offer a change of dates or destination - but there's no guarantee.
Some holiday accommodation will allow refunds until a certain date - so just check the details of your booking first.
By Sarah Taaffe-Maguire , business reporter
The rate of price rises is slowing but consumers are still shopping "more cautiously" at J Sainsbury plc, the company that owns Argos and the Sainsbury's chain of supermarkets announced today.
"Unseasonal" wet weather in recent weeks dampened some sales.
Argos sales were down a worse-than-expected 6.2%, particularly purchases of consumer electronics, most notably gaming sales.
As a result, J Sainsbury plc was the biggest share price faller on the FTSE 100 index of most valuable companies with a 4.34% tumble. Overall the index was down 0.38% on Tuesday morning while the larger FTSE 250 list was 0.15% down.
The strength of the euro still means the pound buys less than for the majority of the last month - £1 = €1.1778. Sterling is also down against the dollar, around levels seen six weeks ago. One pound buys $1.2630.
Bad news for motorists as the oil price is at a two-month high - a barrel of Brent crude oil costs $89.90. It's still below last year's September high point of $98.36.
A popular electric car sold in the UK has a "potentially significant" issue that could veer the driver into oncoming traffic, research has found.
Consumer group Which? says it discovered issues with the MG4's lane-assist technology while testing it on public roads.
It said the system, which is designed to keep the car in lane, twice pulled the car onto the wrong side of the road, with the tester having to use a "significant amount of force" to steer it back.
In another incident on a narrow country road, the lane-assist tech steered the car towards an oncoming vehicle, again forcing the tester to manually intervene.
According to Which?, visibility was good in all cases and the wider road had a "clearly defined centre line, while the country road had a clearly defined edge line".
It said the incidents were noticed during testing outside of controlled lab conditions, and couldn't be repeated in subsequent tests.
The issues come despite MG4 boasting a five-star Euro NCAP score, which takes into account safety features such as lane assist.
A spokesperson for the assessment programme told Which? that manufacturers "have a responsibility to ensure that the vehicle performance seen on a test track is also reflected in on-road driving".
Meanwhile, MG told the consumer watchdog it was "aware of some inconsistencies relating to the lane-departure warning system", making it "oversensitive" in certain conditions.
"We have been working on a continuous improvement programme with the supplier and the relevant regulatory authorities," the company said.
"This has resulted in an improved calibration of the ADAS systems, which we are close to having approved. Once this has been completed, we will implement it as a full software upgrade at no expense to the customer."
MG added that customers can turn off the lane-assist function via the car's touchscreen menu - but it insisted it had received no safety-related reports.
Just 18% of companies in the UK are led by women, and while data suggests female entrepreneurs are on the rise, men still receive more funding and are entrusted with higher average loans to get them started.
In an eight-part series every Tuesday, Money blog reporter Jess Sharp speaks to women who are bossing it in their respective fields - hearing their stories, struggles and advice for those who want to follow in their footsteps by starting a business.
This week, she has spoken to Kelly McCabe, the co-founder of the UK's first virtual cancer care clinic Perci Health...
When Kelly and her co-founder Morgan Fitzsimons set up their business, they made an unusual decision - they sat down and planned when they'd both have children.
It's a topic many men will never feel the need to discuss with their business partners, but as two women, it was something they realistically needed to think about.
"We had a long conversation and made a decision that we would have children at different times so that one person would stay in the business to allow the other to take the time out they needed," Kelly said.
"Of course, you can't plan this thing perfectly, but we were fortunate enough that it kind of happened that way."
Morgan was the first to have her baby and returned to work after a couple of months off, and Kelly gave birth six months later.
A month after having her now nearly two-year-old son, Kelly returned to work and Perci Health has continued to grow ever since.
'Whether it was NHS or private care - I saw the same problem'
Despite Perci Health being a virtual care clinic, Kelly's career background had nothing to do with app development - she started out in the NHS.
One of the roles she had was helping people with cancer eat and drink while receiving treatment.
Working mostly with people with head and neck cancer, she supported them with tube feeding and their rehabilitation back to solid foods.
After working in a similar area in private healthcare, she realised all cancer patients were experiencing the same problem.
"There was a universal experience at the end of treatment where you would have your final review with your cancer nurse or oncologist, and they would say 'see you again in six months or 12 months time'," Kelly said.
"Patients would come back into our follow-up clinics with all sorts of problems they had been living with for six months or 12 months and no one was really managing them.
"They had just be grinning and bearing it, thinking it was just par for the course after having cancer."
She decided to come up with an idea that would connect people living with cancer with professionals who could provide long-term support and optimise their wellbeing.
Male investors in a male-bias sector
With a plan in mind, she reached out to her friend Morgan, who had a background in digital marketing, and the pair got started working weekends and evenings to build their company.
When COVID hit, they made the decision to "just go for it", quit their jobs and put all their focus on the business.
Their first round of funding came from family and friends, raising £500,000, which gave them enough to pay themselves a reduced salary and hire a small team.
But more funding was needed, and they started reaching out to investors.
With Kelly's clinical experience, the issue she was trying to solve in the health care sector seemed "obvious", but the first hurdle she faced was convincing others that it was "important enough to solve".
"The challenges seemed very obvious to us, but they might not necessarily be obvious to investors, and I think that is particularly true if you're solving a problem that affects women," she said.
"The majority of investors are still male... and when you are trying to describe yourself as a technology company, then sadly there is still a male bias in that sector."
"I'm really sad to say that it's kind of the old-fashioned things you think of, like a lot of them sell on the golf course or over lunch or going shooting, and we don't get invited to golf or to shoot.
"You don't get many female-owned technology businesses, so that was a barrier."
Pregnant, pitching and spotting red flags
While meeting potential investors, Kelly was heavily pregnant and was "nervous" to explain her situation out of fear it would put them off investing.
"When I had my first conversation with our now lead investor, I was 38 weeks pregnant, so we just did all the conversations on Zoom," she said.
"She called and said 'we'd like to invite you in to meet the team and do a formal pitch. Can you do it next week?' and obviously I had to tell her I was heavily pregnant.
"She could tell I was nervous about telling her... but she said she was sorry that I had to explain myself, and we could just delay the pitch.
"We pushed it back about six weeks, but not all investors are that understanding, which is why I was so nervous to explain it."
Unfortunately, Kelly said she was "definitely asked" in the early fundraising rounds if she was planning to have children.
"The feedback from male investments clubs was that women don't know how they feel and may not return to work after having a baby or their motivation to run a business may change," she said.
"Early on, we were just looking for investment and we would have taken any partner, but now these are the red flags that we look for.
"There is some definite progress to be made."
In total, Kelly has raised £5m and still owns 40% of Perci Health.
All the challenges
Away from the challenge of fundraising, Kelly also had to deal with life as a new mum, which brought its own challenges as a business owner.
She explained how having children early in the company's life meant it was still "relatively fragile" and there wasn't the chance to take maternity leave knowing her job would be safe when she returned.
"There was a bit of a juggle with that and needing to go back to work very quickly after the baby was born, and then the other challenge is childcare," she said.
"You don't want to be taking too much money out of your business and you're rewarded with equity rather than a salary - but of course, equity doesn't pay for childcare."
Kelly also found there was an "underestimation" of her abilities from male investors, and it was something she noticed in the choice of language used to describe her.
"I believe women business owners are underestimated and that is evidenced by the fact that less investment goes to us, but there's research that shows women-owned companies are more profitable," she said.
"The language they use is interesting. For example, I'm often described as a conservative CEO within the portfolio because I'm focused on financial preservation... but would my male counterpart be seen as such or would he be seen as having optimal control?"
Kelly's advice
Kelly's top tip is to find a business partner, possibly even two, that can help your business grow.
"Building a business alone would be significantly harder," she said.
"Co-founders just help ease the burden when one of you needs to take time out, so find yourself a good business partner."
She also recommended taking "a lot of time" to build a "strong network", which she said would help "protect you as your business grows".
"There are a lot of female entrepreneurs or female business networks that are great. Morgan and I are members of lots of them," she added.
"It's amazing how the amount of advice and support that we have been given for free from other women just wanting to help."
She said it was important to have a "really thick skin and to be very persistent".
"Even in the very best businesses, you get those 100 no's before you get that one yes," she added.
Morrisons is offering shoppers a free jacket potato with Heinz Cheesy Beanz for the next fortnight.
The supermarket chain has joined forces with Heinz to bring back the popular "ask for Henry" initiative which began in 2022 to help people with financial costs during the cost of living crisis.
The complimentary dish is available every day at Morrisons cafes across the country and allows a customer one free jacket potato and beans per day.
There is also no minimum spend required.
But customers will need to use the discrete phrase "ask for Henry" in order to receive it.
The offer ends on 14 July.
Nike plans to launch a cheaper trainer line in an effort to boost sales.
The sporting company's new range will be priced at around £79 or less and will be available in stores across the world, according to Reuters.
Nike has seen sales growth slow as it battles competition from Adidas, as well as the likes of On and Deckers' Hoka brand.
Last Thursday the company reported a sales decline in its latest quarter.
Nike shares also slumped last Friday, ending the day down 19.98%, the biggest one-day percentage drop in the stock's history.
"This is likely a bid to secure some more price-sensitive consumers," GlobalData analyst Neil Saunders said.
Some NatWest customers with paid-for accounts have experienced a big change to their current account fees in the last few days.
The bank hiked the fee for its Reward Black account from £31 to £36 per month as of 28 June - an extra £60 per year.
Perks of the account include UK and European car breakdown cover, access to more than 1,000 airport lounges and worldwide family travel insurance.
For those with a Reward Platinum account, the fee has gone up to £22 from £20, equating to £24 extra throughout the year.
NatWest said increasing insurance costs were one of the drivers behind the fee increases, as well as the claim rate being reported by third-party providers.
It said it had previously frozen the cost of the accounts for five years.
People who hold silver or platinum club accounts with Lloyds are also experiencing a change to their fees from this week.
Club Lloyds Silver now costs £11.50 a month, up from £10 previously, while the platinum account has gone up from £21 to £22.50 a month.
Anyone looking to avoid the fee hike can downgrade their account to a free account or one with a lower payment. There's also the option to switch to another bank.
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July 2, 2024
This article has been reviewed according to Science X's editorial process and policies . Editors have highlighted the following attributes while ensuring the content's credibility:
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by University of Cambridge
Scientists have identified a gene which, when missing or impaired, can cause obesity, behavioral problems and, in mothers, postnatal depression. The discovery, reported in Cell , may have wider implications for the treatment of postnatal depression, with a study in mice suggesting that oxytocin may alleviate symptoms.
Obesity and postnatal depression are significant global health problems. Postnatal depression affects more than one in 10 women within a year of giving birth and is linked to an increased risk of suicide, which accounts for as many as one in five maternal deaths in high income countries. Meanwhile, obesity has more than doubled in adults since 1990 and quadrupled in adolescents, according to the World Health Organization.
While investigating two boys from different families with severe obesity, anxiety, autism, and behavioral problems triggered by sounds or smells, a team led by scientists at the University of Cambridge, UK, and Baylor College of Medicine, Houston, U.S., discovered that the boys were missing a single gene , known as TRPC5, which sits on the X chromosome.
Further investigation revealed that both boys inherited the gene deletion from their mothers, who were missing the gene on one of their X chromosomes. The mothers also had obesity, but in addition had experienced postnatal depression.
To test if it was the TRPC5 gene that was causing the problems in the boys and their mothers, the researchers turned to animal models, genetically-engineering mice with a defective version of the gene (Trpc5 in mice).
Male mice with this defective gene displayed the same problems as the boys, including weight gain , anxiety, a dislike of social interactions, and aggressive behavior . Female mice displayed the same behaviors, but when they became mothers, they also displayed depressive behavior and impaired maternal care. Interestingly, male mice and female mice who were not mothers but carried the mutation did not show depression-like behavior.
Dr. Yong Xu, Associate Director for Basic Sciences at the USDA/ARS Children's Nutrition Research Center at Baylor College of Medicine, said, "What we saw in those mice was quite remarkable. They displayed very similar behaviors to those seen in people missing the TRPC5 gene, which in mothers included signs of depression and a difficulty caring for their babies. This shows us that this gene is causing these behaviors."
TRPC5 is one of a family of genes that are involved in detecting sensory signals, such as heat, taste and touch. This particular gene acts on a pathway in the hypothalamus region of the brain, where it is known to control appetite.
When the researchers looked in more detail at this brain region, they discovered that TRPC5 acts on oxytocin neurons—nerve cells that produce the hormone oxytocin, often nicknamed the 'love hormone' because of its release in response to displays of affection, emotion and bonding.
Deleting the gene from these oxytocin neurons led to otherwise healthy mice showing similar signs of anxiety, overeating and impaired sociability, and, in the case of mothers, postnatal depression. Restoring the gene in these neurons reduced body weight and symptoms of anxiety and postnatal depression.
In addition to acting on oxytocin neurons, the team showed that TRPC5 also acts on so-called POMC neurons, which have been known for some time to play an important role in regulating weight. Children in whom the POMC gene is not working properly often have an insatiable appetite and gain weight from an early age.
Professor Sadaf Farooqi from the Institute of Metabolic Science at the University of Cambridge said, "There's a reason why people lacking TRPC5 develop all of these conditions. We've known for a long time that the hypothalamus plays a key role in regulating 'instinctive behaviors'—which enable humans and animals to survive—such as looking for food, social interaction, the flight or fight response, and caring for their infants. Our work shows that TRPC5 acts on oxytocin neurons in the hypothalamus to play a critical role in regulating our instincts."
While deletions of the TRPC5 gene are rare, an analysis of DNA samples from around 500,000 individuals in UK Biobank revealed 369 people—around three-quarters of whom were women—that carried variants of the gene and had a higher-than-average body mass index.
The researchers say their findings suggest that restoring oxytocin could help treat people with missing or defective TRPC5 genes, and potentially mothers experiencing postnatal depression.
Professor Farooqi said, "While some genetic conditions such as TRPC5 deficiency are very rare, they teach us important lessons about how the body works. In this instance, we have made a breakthrough in understanding postnatal depression, a serious health problem about which very little is known despite many decades of research. And importantly, it may point to oxytocin as a possible treatment for some mothers with this condition."
There is already evidence in animals that the oxytocin system is involved in both depression and in maternal care and there have been small trials into the use of oxytocin as a treatment. The team say their work provides direct proof of oxytocin 's role, which will be crucial in supporting bigger, multi-center trials.
Professor Farooqi added, "This research reminds us that many behaviors which we assume are entirely under our control have a strong basis in biology, whether that's our eating behavior, anxiety or postnatal depression. We need to be more understanding and sympathetic towards people who suffer with these conditions."
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Characteristics, Types, and Examples. August 22, 2023 Sunaina Singh. Knowing the basics of defining a research problem is instrumental in formulating a research inquiry. A research problem is a gap in existing knowledge, a contradiction in an established theory, or a real-world challenge that a researcher aims to address in their research.
A research problem is a specific issue or gap in existing knowledge that you aim to address in your research. Learn how to identify, refine, and formulate a research problem for practical or theoretical research.
The research problem, therefore, is the main organizing principle guiding the analysis of your research. The problem under investigation establishes an occasion for writing and a focus that governs what you want to say. It represents the core subject matter of scholarly communication and the means by which scholars arrive at other topics of ...
May 21, 2024. Identifying a research problem is a crucial first step in the research process, serving as the foundation for all subsequent research activities. This guide provides a comprehensive overview of the steps involved in identifying a research problem, from understanding its essence to employing advanced strategies for refinement.
A research problem is a specific and well-defined issue or question that a researcher seeks to investigate through research. It should be feasible, relevant, and important to the field of study. Learn how to define, refine, and develop a research problem with examples from various disciplines.
Learn how to identify and formulate a research problem that is feasible, relevant, and interesting. Explore key questions, literature, and methods to guide your research design process.
Do not state the research problem as simply the absence of the thing you are suggesting. For example, if you propose the following, "The problem in this community is that there is no hospital," this only leads to a research problem where: The need is for a hospital; The objective is to create a hospital; The method is to plan for building a ...
A compelling research problem not only captivates the attention of your peers but also lays the foundation for impactful and meaningful research outcomes. ... Feasibility: Ensure that your research problem is feasible within the constraints of time, resources, and available data. Unrealistic research problems can hinder the progress of your study.
The Problem Should Be Feasible. A research problem (or a research question) should be feasible in two respects. As Sim and Wright [ 16] have noted, it should be feasible on a "conceptual-empirical" level, meaning that the concepts and propositions embodied in the research should be susceptible to empirical evaluation.
A research problem can be theoretical in nature, focusing on an area of academic research that is lacking in some way. Alternatively, a research problem can be more applied in nature, focused on finding a practical solution to an established problem within an industry or an organisation. In other words, theoretical research problems are motivated by the desire to grow the overall body of ...
searchable problem, the literature review and the significance ofthe problem under investigation (McKechnie & Rogers, 1985; Tornquist & Rogers, 1987). Each of TABLE Assessing the Feasibility of a Research Problem Commitment and interest ofthe researcher. Scientific merit ofthe proposed research. Timeallotment to study the problem.
Data accessibility; The researcher would choose the issue if the desired data were available. Urgency; A defining factor in the choice of a research problem is urgency, priority must be given to urgent issues because they may benefit from quick solutions. Feasibility; A key consideration in choosing the research problem is feasibility, the ...
Only a few of these ideas will make it into a study. Next, we describe how to sharpen and focus a research question so that a study becomes feasible and a valid test of the underlying idea. To do this, the idea needs to be "pruned". Pruning a research question means cutting away anything that is unnecessary, so that only the essence remains.
The research problem is only a problem statement and it does not describe how to do something. It must be remembered that a research problem is always related to some kind of management dilemma ... At least two feasible outcomes of the course of action and out of two outcomes, one outcome should be more preferable to the other; A research ...
It refers to a specific topic, problem, or knowledge gap that a researcher aims to study and address through a systematic inquiry. It establishes the foundation for a research project and guides the entire investigation. When creating a research problem, researchers often start with a topic of interest before focusing on a particular issue or ...
A good research question is essential to guide your research paper, dissertation, or thesis. All research questions should be: Focused on a single problem or issue. Researchable using primary and/or secondary sources. Feasible to answer within the timeframe and practical constraints. Specific enough to answer thoroughly.
Perhaps you discover that a study you had your heart set on involves a vulnerable population and, as a result, the IRB has denied your request to do this study (yes, they can and will do that in certain circumstances). In order to discover a study topic that is not only feasible but also reasonable, justifiable, and necessary, you may find it ...
A research problem is feasible only when it is relevant, measurable, and has sufficient resources and support. The article discusses the factors that affect the researchability and feasibility of occupational health research, such as researcher commitment, administrative cooperation, ethical parameters, and subject participation.
Feasibility: The research problem should be feasible in terms of resources, time, and practicality. It should be possible to conduct the research within the available constraints. Social significance: A research problem should be socially significant, meaning that it addresses issues or problems relevant to society, communities, or individuals.
A research problem is not feasible only when: (A) it is researchable (B) it is new and adds something to the knowledge ... Options (A), (B), and (D) are more relevant to the feasibility of a research problem. Q32. The process not needed in experimental research is: (A) Observation (B) Manipulation and replication (C) Controlling (D) Reference ...
It develops self-confidence in children. B. It makes learning easy. C. It is helpful in intellectual development. D. It helps children in learning in natural atmosphere. View Answer. A research problem is feasible only when it is a) It is researchable b) It is new and adds something to knowledge c) It has utility and relevance d) All of these.
All of the above. SOLUTION. A research problem is feasible only when. It has utility and relevance. It is new and adds something to knowledge. It is researchable. A research problem can be defined as a statement about the area of interest, a condition that is required to be improved, a difficulty that has to be eradicated, or any disquieting ...
A research problem is not feasible only when it consists of independent and dependent variables It must have utility and relevance Hence a research report must specify the concept clearly and properly so that it can improve the theories A research problem is defined as the area of improvement in the research report related to a specific problem.
The latest research on the prevalence of aspirin use to prevent cardiovascular disease suggests that in 2021, nearly a third of adults 60 or older without cardiovascular disease were still using ...
This story is part of our Cosmic Perspective series, in which we confront the staggering vastness of the cosmos and our place in it. Read the rest of the series here. We think our universe ...
Medical research has shortchanged women for decades. This is particularly true of older women, leaving physicians without critically important information about how to best manage their health.
The problem is that Harris is about as unpopular as Biden is. Recent surveys from Monmouth University and Suffolk University have shown disapproval of her outpacing approval by 18 and 16 points ...
There is a process, but it would be messy.
High temperatures and droughts in Spain, the world's leading producer and exporter, have dented the harvest - a problem only worsened by global inflationary pressures.
Obesity and postnatal depression are significant global health problems. Postnatal depression affects more than one in 10 women within a year of giving birth and is linked to an increased risk of ...