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Recently published articles from subdisciplines of psychology covered by more than 90 APA Journals™ publications.

For additional free resources (such as article summaries, podcasts, and more), please visit the Highlights in Psychological Research page.

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• Moving While Black: Intergroup Attitudes Influence Judgments of Speed (PDF, 71KB) Journal of Experimental Psychology: General February 2016 by Andreana C. Kenrick, Stacey Sinclair, Jennifer Richeson, Sara C. Verosky, and Janetta Lun
• Recognition Without Awareness: Encoding and Retrieval Factors (PDF, 116KB) Journal of Experimental Psychology: Learning, Memory, and Cognition September 2015 by Fergus I. M. Craik, Nathan S. Rose, and Nigel Gopie
• The Tip-of-the-Tongue Heuristic: How Tip-of-the-Tongue States Confer Perceptibility on Inaccessible Words (PDF, 91KB) Journal of Experimental Psychology: Learning, Memory, and Cognition September 2015 by Anne M. Cleary and Alexander B. Claxton
• Cognitive Processes in the Breakfast Task: Planning and Monitoring (PDF, 146KB) Canadian Journal of Experimental Psychology / Revue canadienne de psychologie expérimentale September 2015 by Nathan S. Rose, Lin Luo, Ellen Bialystok, Alexandra Hering, Karen Lau, and Fergus I. M. Craik
• Searching for Explanations: How the Internet Inflates Estimates of Internal Knowledge (PDF, 138KB) Journal of Experimental Psychology: General June 2015 by Matthew Fisher, Mariel K. Goddu, and Frank C. Keil
• Client Perceptions of Corrective Experiences in Cognitive Behavioral Therapy and Motivational Interviewing for Generalized Anxiety Disorder: An Exploratory Pilot Study (PDF, 62KB) Journal of Psychotherapy Integration March 2017 by Jasmine Khattra, Lynne Angus, Henny Westra, Christianne Macaulay, Kathrin Moertl, and Michael Constantino
• Attention-Deficit/Hyperactivity Disorder Developmental Trajectories Related to Parental Expressed Emotion (PDF, 160KB) Journal of Abnormal Psychology February 2016 by Erica D. Musser, Sarah L. Karalunas, Nathan Dieckmann, Tara S. Peris, and Joel T. Nigg
• The Integrated Scientist-Practitioner: A New Model for Combining Research and Clinical Practice in Fee-For-Service Settings (PDF, 58KB) Professional Psychology: Research and Practice December 2015 by Jenna T. LeJeune and Jason B. Luoma
• Psychotherapists as Gatekeepers: An Evidence-Based Case Study Highlighting the Role and Process of Letter Writing for Transgender Clients (PDF, 76KB) Psychotherapy September 2015 by Stephanie L. Budge
• Perspectives of Family and Veterans on Family Programs to Support Reintegration of Returning Veterans With Posttraumatic Stress Disorder (PDF, 70KB) Psychological Services August 2015 by Ellen P. Fischer, Michelle D. Sherman, Jean C. McSweeney, Jeffrey M. Pyne, Richard R. Owen, and Lisa B. Dixon
• "So What Are You?": Inappropriate Interview Questions for Psychology Doctoral and Internship Applicants (PDF, 79KB) Training and Education in Professional Psychology May 2015 by Mike C. Parent, Dana A. Weiser, and Andrea McCourt
• Cultural Competence as a Core Emphasis of Psychoanalytic Psychotherapy (PDF, 81KB) Psychoanalytic Psychology April 2015 by Pratyusha Tummala-Narra
• The Role of Gratitude in Spiritual Well-Being in Asymptomatic Heart Failure Patients (PDF, 123KB) Spirituality in Clinical Practice March 2015 by Paul J. Mills, Laura Redwine, Kathleen Wilson, Meredith A. Pung, Kelly Chinh, Barry H. Greenberg, Ottar Lunde, Alan Maisel, Ajit Raisinghani, Alex Wood, and Deepak Chopra
• Nepali Bhutanese Refugees Reap Support Through Community Gardening (PDF, 104KB) International Perspectives in Psychology: Research, Practice, Consultation January 2017 by Monica M. Gerber, Jennifer L. Callahan, Danielle N. Moyer, Melissa L. Connally, Pamela M. Holtz, and Beth M. Janis
• Does Monitoring Goal Progress Promote Goal Attainment? A Meta-Analysis of the Experimental Evidence (PDF, 384KB) Psychological Bulletin February 2016 by Benjamin Harkin, Thomas L. Webb, Betty P. I. Chang, Andrew Prestwich, Mark Conner, Ian Kellar, Yael Benn, and Paschal Sheeran
• Youth Violence: What We Know and What We Need to Know (PDF, 388KB) American Psychologist January 2016 by Brad J. Bushman, Katherine Newman, Sandra L. Calvert, Geraldine Downey, Mark Dredze, Michael Gottfredson, Nina G. Jablonski, Ann S. Masten, Calvin Morrill, Daniel B. Neill, Daniel Romer, and Daniel W. Webster
• Supervenience and Psychiatry: Are Mental Disorders Brain Disorders? (PDF, 113KB) Journal of Theoretical and Philosophical Psychology November 2015 by Charles M. Olbert and Gary J. Gala
• Constructing Psychological Objects: The Rhetoric of Constructs (PDF, 108KB) Journal of Theoretical and Philosophical Psychology November 2015 by Kathleen L. Slaney and Donald A. Garcia
• Expanding Opportunities for Diversity in Positive Psychology: An Examination of Gender, Race, and Ethnicity (PDF, 119KB) Canadian Psychology / Psychologie canadienne August 2015 by Meghana A. Rao and Stewart I. Donaldson
• Racial Microaggression Experiences and Coping Strategies of Black Women in Corporate Leadership (PDF, 132KB) Qualitative Psychology August 2015 by Aisha M. B. Holder, Margo A. Jackson, and Joseph G. Ponterotto
• An Appraisal Theory of Empathy and Other Vicarious Emotional Experiences (PDF, 151KB) Psychological Review July 2015 by Joshua D. Wondra and Phoebe C. Ellsworth
• An Attachment Theoretical Framework for Personality Disorders (PDF, 100KB) Canadian Psychology / Psychologie canadienne May 2015 by Kenneth N. Levy, Benjamin N. Johnson, Tracy L. Clouthier, J. Wesley Scala, and Christina M. Temes
• Emerging Approaches to the Conceptualization and Treatment of Personality Disorder (PDF, 111KB) Canadian Psychology / Psychologie canadienne May 2015 by John F. Clarkin, Kevin B. Meehan, and Mark F. Lenzenweger
• A Complementary Processes Account of the Development of Childhood Amnesia and a Personal Past (PDF, 585KB) Psychological Review April 2015 by Patricia J. Bauer
• Terminal Decline in Well-Being: The Role of Social Orientation (PDF, 238KB) Psychology and Aging March 2016 by Denis Gerstorf, Christiane A. Hoppmann, Corinna E. Löckenhoff, Frank J. Infurna, Jürgen Schupp, Gert G. Wagner, and Nilam Ram
• Student Threat Assessment as a Standard School Safety Practice: Results From a Statewide Implementation Study (PDF, 97KB) School Psychology Quarterly June 2018 by Dewey Cornell, Jennifer L. Maeng, Anna Grace Burnette, Yuane Jia, Francis Huang, Timothy Konold, Pooja Datta, Marisa Malone, and Patrick Meyer
• Can a Learner-Centered Syllabus Change Students’ Perceptions of Student–Professor Rapport and Master Teacher Behaviors? (PDF, 90KB) Scholarship of Teaching and Learning in Psychology September 2016 by Aaron S. Richmond, Jeanne M. Slattery, Nathanael Mitchell, Robin K. Morgan, and Jared Becknell
• Adolescents' Homework Performance in Mathematics and Science: Personal Factors and Teaching Practices (PDF, 170KB) Journal of Educational Psychology November 2015 by Rubén Fernández-Alonso, Javier Suárez-Álvarez, and José Muñiz
• Teacher-Ready Research Review: Clickers (PDF, 55KB) Scholarship of Teaching and Learning in Psychology September 2015 by R. Eric Landrum
• Enhancing Attention and Memory During Video-Recorded Lectures (PDF, 83KB) Scholarship of Teaching and Learning in Psychology March 2015 by Daniel L. Schacter and Karl K. Szpunar
• The Alleged "Ferguson Effect" and Police Willingness to Engage in Community Partnership (PDF, 70KB) Law and Human Behavior February 2016 by Scott E. Wolfe and Justin Nix
• Randomized Controlled Trial of an Internet Cognitive Behavioral Skills-Based Program for Auditory Hallucinations in Persons With Psychosis (PDF, 92KB) Psychiatric Rehabilitation Journal September 2017 by Jennifer D. Gottlieb, Vasudha Gidugu, Mihoko Maru, Miriam C. Tepper, Matthew J. Davis, Jennifer Greenwold, Ruth A. Barron, Brian P. Chiko, and Kim T. Mueser
• Preventing Unemployment and Disability Benefit Receipt Among People With Mental Illness: Evidence Review and Policy Significance (PDF, 134KB) Psychiatric Rehabilitation Journal June 2017 by Bonnie O'Day, Rebecca Kleinman, Benjamin Fischer, Eric Morris, and Crystal Blyler
• Sending Your Grandparents to University Increases Cognitive Reserve: The Tasmanian Healthy Brain Project (PDF, 88KB) Neuropsychology July 2016 by Megan E. Lenehan, Mathew J. Summers, Nichole L. Saunders, Jeffery J. Summers, David D. Ward, Karen Ritchie, and James C. Vickers
• The Foundational Principles as Psychological Lodestars: Theoretical Inspiration and Empirical Direction in Rehabilitation Psychology (PDF, 68KB) Rehabilitation Psychology February 2016 by Dana S. Dunn, Dawn M. Ehde, and Stephen T. Wegener
• Feeling Older and Risk of Hospitalization: Evidence From Three Longitudinal Cohorts (PDF, 55KB) Health Psychology Online First Publication — February 11, 2016 by Yannick Stephan, Angelina R. Sutin, and Antonio Terracciano
• Anger Intensification With Combat-Related PTSD and Depression Comorbidity (PDF, 81KB) Psychological Trauma: Theory, Research, Practice, and Policy January 2016 by Oscar I. Gonzalez, Raymond W. Novaco, Mark A. Reger, and Gregory A. Gahm
• Special Issue on eHealth and mHealth: Challenges and Future Directions for Assessment, Treatment, and Dissemination (PDF, 32KB) Health Psychology December 2015 by Belinda Borrelli and Lee M. Ritterband
• Posttraumatic Growth Among Combat Veterans: A Proposed Developmental Pathway (PDF, 110KB) Psychological Trauma: Theory, Research, Practice, and Policy July 2015 by Sylvia Marotta-Walters, Jaehwa Choi, and Megan Doughty Shaine
• Racial and Sexual Minority Women's Receipt of Medical Assistance to Become Pregnant (PDF, 111KB) Health Psychology June 2015 by Bernadette V. Blanchfield and Charlotte J. Patterson
• An Examination of Generational Stereotypes as a Path Towards Reverse Ageism (PDF, 205KB) The Psychologist-Manager Journal August 2017 By Michelle Raymer, Marissa Reed, Melissa Spiegel, and Radostina K. Purvanova
• Sexual Harassment: Have We Made Any Progress? (PDF, 121KB) Journal of Occupational Health Psychology July 2017 By James Campbell Quick and M. Ann McFadyen
• Multidimensional Suicide Inventory-28 (MSI-28) Within a Sample of Military Basic Trainees: An Examination of Psychometric Properties (PDF, 79KB) Military Psychology November 2015 By Serena Bezdjian, Danielle Burchett, Kristin G. Schneider, Monty T. Baker, and Howard N. Garb
• Cross-Cultural Competence: The Role of Emotion Regulation Ability and Optimism (PDF, 100KB) Military Psychology September 2015 By Bianca C. Trejo, Erin M. Richard, Marinus van Driel, and Daniel P. McDonald
• The Effects of Stress on Prospective Memory: A Systematic Review (PDF, 149KB) Psychology & Neuroscience September 2017 by Martina Piefke and Katharina Glienke
• Don't Aim Too High for Your Kids: Parental Overaspiration Undermines Students' Learning in Mathematics (PDF, 164KB) Journal of Personality and Social Psychology November 2016 by Kou Murayama, Reinhard Pekrun, Masayuki Suzuki, Herbert W. Marsh, and Stephanie Lichtenfeld
• Sex Differences in Sports Interest and Motivation: An Evolutionary Perspective (PDF, 155KB) Evolutionary Behavioral Sciences April 2016 by Robert O. Deaner, Shea M. Balish, and Michael P. Lombardo
• Asian Indian International Students' Trajectories of Depression, Acculturation, and Enculturation (PDF, 210KB) Asian American Journal of Psychology March 2016 By Dhara T. Meghani and Elizabeth A. Harvey
• Cynical Beliefs About Human Nature and Income: Longitudinal and Cross-Cultural Analyses (PDF, 163KB) January 2016 Journal of Personality and Social Psychology by Olga Stavrova and Daniel Ehlebracht
• Annual Review of Asian American Psychology, 2014 (PDF, 384KB) Asian American Journal of Psychology December 2015 By Su Yeong Kim, Yishan Shen, Yang Hou, Kelsey E. Tilton, Linda Juang, and Yijie Wang
• Resilience in the Study of Minority Stress and Health of Sexual and Gender Minorities (PDF, 40KB) Psychology of Sexual Orientation and Gender Diversity September 2015 by Ilan H. Meyer
• Self-Reported Psychopathy and Its Association With Criminal Cognition and Antisocial Behavior in a Sample of University Undergraduates (PDF, 91KB) Canadian Journal of Behavioural Science / Revue canadienne des sciences du comportement July 2015 by Samantha J. Riopka, Richard B. A. Coupland, and Mark E. Olver

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Collection  12 March 2023

Journal Top 100 - 2022

This collection highlights our most downloaded* research papers published in 2022. Featuring authors from around the world, these papers highlight valuable research from an international community.

You can also check out the Top 100 across various subject areas here .

*Data obtained from SN Insights, which is based on Digital Science’s Dimensions.

mRNA vaccine-induced antibodies more effective than natural immunity in neutralizing SARS-CoV-2 and its high affinity variants

• Dominic Esposito

Cats learn the names of their friend cats in their daily lives

• Saho Takagi
• Atsuko Saito
• Hika Kuroshima

Metformin administration is associated with enhanced response to transarterial chemoembolization for hepatocellular carcinoma in type 2 diabetes patients

• Woo Jin Jung
• Sangmi Jang
• Jin-Wook Kim

The impact of digital media on children’s intelligence while controlling for genetic differences in cognition and socioeconomic background

• Bruno Sauce
• Magnus Liebherr
• Torkel Klingberg

Life tables of annual life expectancy and mortality for companion dogs in the United Kingdom

• Kendy Tzu-yun Teng
• Dave C. Brodbelt
• Dan G. O’Neill

Bioarchaeological and palaeogenomic portrait of two Pompeians that died during the eruption of Vesuvius in 79 AD

• Gabriele Scorrano
• Serena Viva
• Fabio Macciardi

Reading on a smartphone affects sigh generation, brain activity, and comprehension

• Motoyasu Honma
• Yuri Masaoka
• Masahiko Izumizaki

Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated

• Eran Elhaik

The determinants of COVID-19 morbidity and mortality across countries

• Dianna Chang
• Kelvin Jui Keng Tan

Birdsongs alleviate anxiety and paranoia in healthy participants

• J. Sundermann

Identification of ADS024, a newly characterized strain of Bacillus velezensis with direct Clostridiodes difficile killing and toxin degradation bio-activities

• Michelle M. O’Donnell
• James W. Hegarty
• Laurent Chesnel

Multiple sclerosis genetic and non-genetic factors interact through the transient transcriptome

• Renato Umeton
• Gianmarco Bellucci
• Giovanni Ristori

The effect of metformin on the survival of colorectal cancer patients with type 2 diabetes mellitus

• Zeinab Tarhini
• Kamelia Manceur
• Niki Christou

Chemical characterisation of the vapour emitted by an e-cigarette using a ceramic wick-based technology

• M. Isabel Pinto

Large-magnitude (VEI ≥ 7) ‘wet’ explosive silicic eruption preserved a Lower Miocene habitat at the Ipolytarnóc Fossil Site, North Hungary

• Dávid Karátson
• Imre Szarvas

Far-UVC (222 nm) efficiently inactivates an airborne pathogen in a room-sized chamber

• Waseem Hiwar
• Kenneth Wood

Low dose aspirin associated with greater bone mineral density in older adults

• Hongzhan Liu
• Xungang Xiao

First direct evidence of adult European eels migrating to their breeding place in the Sargasso Sea

• Rosalind M. Wright
• Adam T. Piper
• David Righton

Infections with the SARS-CoV-2 Delta variant exhibit fourfold increased viral loads in the upper airways compared to Alpha or non-variants of concern

• Christian J. H. von Wintersdorff
• Jozef Dingemans
• Paul H. M. Savelkoul

Inappropriate sinus tachycardia in post-COVID-19 syndrome

• Júlia Aranyó
• Victor Bazan
• Roger Villuendas

The microstructure and the origin of the Venus from Willendorf

• Gerhard W. Weber
• Alexander Lukeneder

COVID-19 reinfections among naturally infected and vaccinated individuals

• Sezanur Rahman
• M. Mahfuzur Rahman
• Mustafizur Rahman

Lockdown measures during the COVID-19 pandemic strongly impacted the circulation of respiratory pathogens in Southern China

• Heping Wang
• Yuejie Zheng
• Wenjian Wang

Alzheimer’s disease large-scale gene expression portrait identifies exercise as the top theoretical treatment

• Mason A. Hill
• Stephen C. Gammie

COVID-19 symptoms are reduced by targeted hydration of the nose, larynx and trachea

• Carolin Elizabeth George
• Gerhard Scheuch
• David A. Edwards

SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death

• Junyoung Oh
• Woo-Hyun Cho
• Sung Joong Lee

Abdominal pain patterns during COVID-19: an observational study

• Alexandre Balaphas
• Kyriaki Gkoufa
• Christian Toso

Detection of human pathogenic bacteria in rectal DNA samples from Zalophus californianus in the Gulf of California, Mexico

• Francesco Cicala
• David Ramírez-Delgado
• Alexei F. Licea-Navarro

Industrialised fishing nations largely contribute to floating plastic pollution in the North Pacific subtropical gyre

• Laurent Lebreton
• Sarah-Jeanne Royer
• Matthias Egger

Hypertension and diabetes including their earlier stage are associated with increased risk of sudden cardiac arrest

• Seung Young Roh
• Young-Hoon Kim

Utility of an artificial intelligence system for classification of esophageal lesions when simulating its clinical use

• Ayaka Tajiri
• Ryu Ishihara
• Tomohiro Tada

Prevalence, age of decision, and interpersonal warmth judgements of childfree adults

• Zachary P. Neal
• Jennifer Watling Neal

Acute and protracted abstinence from methamphetamine bidirectionally changes intrinsic excitability of indirect pathway spiny projection neurons in the dorsomedial striatum

• Sanghoon Choi
• Steven M. Graves

Indeterminacy of cannabis impairment and ∆ 9 -tetrahydrocannabinol (∆ 9 -THC) levels in blood and breath

• Gregory T. Wurz
• Michael W. DeGregorio

High rates of plasmid cotransformation in E. coli overturn the clonality myth and reveal colony development

• Delia Tomoiaga
• Jaclyn Bubnell
• Paul Feinstein

Metformin sensitizes leukemic cells to cytotoxic lymphocytes by increasing expression of intercellular adhesion molecule-1 (ICAM-1)

• Nerea Allende-Vega
• Joaquin Marco Brualla
• Martin Villalba

Incorporation of machine learning and deep neural network approaches into a remote sensing-integrated crop model for the simulation of rice growth

• Seungtaek Jeong
• Jong-min Yeom

Perceiving societal pressure to be happy is linked to poor well-being, especially in happy nations

• Egon Dejonckheere
• Joshua J. Rhee
• Brock Bastian

The earliest Pleistocene record of a large-bodied hominin from the Levant supports two out-of-Africa dispersal events

• Alon Barash
• Miriam Belmaker

Generation mechanism and prediction of an observed extreme rogue wave

• Johannes Gemmrich

Fitness tracking reveals task-specific associations between memory, mental health, and physical activity

• Jeremy R. Manning
• Gina M. Notaro
• Paxton C. Fitzpatrick

Domestic dogs ( Canis familiaris ) grieve over the loss of a conspecific

• Stefania Uccheddu
• Lucia Ronconi
• Federica Pirrone

Human transgenerational observations of regular smoking before puberty on fat mass in grandchildren and great-grandchildren

• Jean Golding
• Steve Gregory
• Matthew Suderman

Chlamydia pneumoniae can infect the central nervous system via the olfactory and trigeminal nerves and contributes to Alzheimer’s disease risk

• Jenny A. K. Ekberg

Oxycodone/naloxone versus tapentadol in real-world chronic non-cancer pain management: an observational and pharmacogenetic study

• Jordi Barrachina
• Cesar Margarit
• Ana M. Peiró

Cooking methods are associated with inflammatory factors, renal function, and other hormones and nutritional biomarkers in older adults

• Montserrat Rodríguez-Ayala
• José Ramón Banegas
• Pilar Guallar-Castillón

Classification of pig calls produced from birth to slaughter according to their emotional valence and context of production

• Elodie F. Briefer
• Ciara C.-R. Sypherd
• Céline Tallet

Higher emotional awareness is associated with greater domain-general reflective tendencies

• Michelle Persich
• William D. S. Killgore

A large Megaraptoridae (Theropoda: Coelurosauria) from Upper Cretaceous (Maastrichtian) of Patagonia, Argentina

• Alexis M. Aranciaga Rolando
• Matias J. Motta
• Fernando E. Novas

Long COVID occurrence in COVID-19 survivors

• Aya Sugiyama
• Junko Tanaka

Water activated disposable paper battery

• Alexandre Poulin
• Xavier Aeby
• Gustav Nyström

Intestinal preservation in a birdlike dinosaur supports conservatism in digestive canal evolution among theropods

• Yichuan Liu

Antiviral effect of cetylpyridinium chloride in mouthwash on SARS-CoV-2

• Hirofumi Sawa

Evidence of an oceanic impact and megatsunami sedimentation in Chryse Planitia, Mars

• J. Alexis P. Rodriguez
• Darrel K. Robertson
• Mario Zarroca

Curcumin and metformin synergistically modulate peripheral and central immune mechanisms of pain

• Peththa Wadu Dasuni Wasana
• Pasarapa Towiwat

The first occurrence of an avian-style respiratory infection in a non-avian dinosaur

• D. Cary Woodruff
• Ewan D. S. Wolff
• Lawrence M. Witmer

Optimal linear estimation models predict 1400–2900 years of overlap between Homo sapiens and Neandertals prior to their disappearance from France and northern Spain

• Igor Djakovic
• Alastair Key
• Marie Soressi

The influence of time on the sensitivity of SARS-CoV-2 serological testing

• Arturo Torres Ortiz
• Fernanda Fenn Torrente
• Louis Grandjean

Online misinformation is linked to early COVID-19 vaccination hesitancy and refusal

• Francesco Pierri
• Brea L. Perry
• John Bryden

A distinct symptom pattern emerges for COVID-19 long-haul: a nationwide study

• Melissa D. Pinto
• Charles A. Downs
• Natalie Lambert

SARS-CoV-2-reactive IFN-γ-producing CD4 + and CD8 + T cells in blood do not correlate with clinical severity in unvaccinated critically ill COVID-19 patients

• Beatriz Olea
• Eliseo Albert
• David Navarro

Classification of 74 facial emoji’s emotional states on the valence-arousal axes

• Gaku Kutsuzawa
• Hiroyuki Umemura
• Yoshiyuki Kobayashi

The emergence of a new sex-system (XX/XY 1 Y 2 ) suggests a species complex in the “monotypic” rodent Oecomys auyantepui (Rodentia, Sigmodontinae)

• Willam Oliveira da Silva
• Celina Coelho Rosa
• Cleusa Yoshiko Nagamachi

Detection of COVID-19 using multimodal data from a wearable device: results from the first TemPredict Study

• Ashley E. Mason
• Frederick M. Hecht
• Benjamin L. Smarr

Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain

• Jeffrey R. Cooley
• Tue S. Jensen
• Jeffrey J. Hebert

Phenomenology and content of the inhaled N , N -dimethyltryptamine ( N , N -DMT) experience

• David Wyndham Lawrence
• Robin Carhart-Harris
• Christopher Timmermann

A gigantic bizarre marine turtle (Testudines: Chelonioidea) from the Middle Campanian (Late Cretaceous) of South-western Europe

• Oscar Castillo-Visa
• Àngel H. Luján
• Albert Sellés

The first experience with fully endoscopic posterior cervical foraminotomy and discectomy for radiculopathy performed in Viet Duc University Hospital

• Son Ngoc Dinh
• Hung The Dinh

Mapping the “catscape” formed by a population of pet cats with outdoor access

• Richard Bischof
• Nina Rosita Hansen
• Torbjørn Haugaasen

Investigation of humans individual differences as predictors of their animal interaction styles, focused on the domestic cat

• Lauren R. Finka
• Lucia Ripari
• Marnie L. Brennan

Genesis of fecal floatation is causally linked to gut microbial colonization in mice

• Syed Mohammed Musheer Aalam
• Daphne Norma Crasta
• Nagarajan Kannan

Young children’s screen time during the first COVID-19 lockdown in 12 countries

• Christina Bergmann
• Nevena Dimitrova
• Nivedita Mani

Cichlids and stingrays can add and subtract ‘one’ in the number space from one to five

• V. Schluessel

Elevated estradiol levels in frozen embryo transfer have different effects on pregnancy outcomes depending on the stage of transferred embryos

• Liming Ruan

Group VR experiences can produce ego attenuation and connectedness comparable to psychedelics

• David R. Glowacki
• Rhoslyn Roebuck Williams
• Mike Chatziapostolou

New therizinosaurid dinosaur from the marine Osoushinai Formation (Upper Cretaceous, Japan) provides insight for function and evolution of therizinosaur claws

• Yoshitsugu Kobayashi
• Ryuji Takasaki
• Yoshinori Hikida

Smartphone-based ecological momentary assessment reveals mental health benefits of birdlife

• Ryan Hammoud
• Stefania Tognin
• Andrea Mechelli

Long-term outcomes of cataract surgery with toric intraocular lens implantation by the type of preoperative astigmatism

• Tetsuro Oshika
• Shinichiro Nakano
• Tsutomu Kaneko

Forest fire detection system using wireless sensor networks and machine learning

• Udaya Dampage
• Lumini Bandaranayake
• Bathiya Jayasanka

Misinformation of COVID-19 vaccines and vaccine hesitancy

• Sun Kyong Lee
• Juhyung Sun
• Shane Connelly

Deep language algorithms predict semantic comprehension from brain activity

• Charlotte Caucheteux
• Alexandre Gramfort
• Jean-Rémi King

Children with autism spectrum disorder show atypical electroencephalographic response to processing contextual incongruencies

• Amparo V. Márquez-García
• Vasily A. Vakorin
• Sam M. Doesburg

A generalizable one health framework for the control of zoonotic diseases

• Ria R. Ghai
• Ryan M. Wallace
• Casey Barton Behravesh

HS3ST2 expression induces the cell autonomous aggregation of tau

• M. B. Huynh
• N. Rebergue
• D. Papy-Garcia

Exceptional warming over the Barents area

• Ketil Isaksen
• Øyvind Nordli
• Tatiana Karandasheva

A new Early Cretaceous lizard in Myanmar amber with exceptionally preserved integument

• Andrej Čerňanský
• Edward L. Stanley
• Susan E. Evans

Coffee consumption and diabetic retinopathy in adults with diabetes mellitus

• Hak Jun Lee
• Daniel Duck-Jin Hwang

Shifts in the foraging tactics of crocodiles following invasion by toxic prey

• Abhilasha Aiyer
• Richard Shine
• Georgia Ward-Fear

Production of high loading insulin nanoparticles suitable for oral delivery by spray drying and freeze drying techniques

• Alberto Baldelli
• Anubhav Pratap-Singh

Cable news and COVID-19 vaccine uptake

• Matteo Pinna
• Christoph Goessmann

Estimating the time of last drinking from blood ethyl glucuronide and ethyl sulphate concentrations

• Zhongyuan Guo

COVID-19 infections in infants

• Małgorzata Sobolewska-Pilarczyk
• Maria Pokorska-Śpiewak
• Małgorzata Pawłowska

COVID-19 increases the risk for the onset of atrial fibrillation in hospitalized patients

• Jakob Wollborn
• Sergey Karamnov
• Jochen D. Muehlschlegel

Childhood temperament and adulthood personality differentially predict life outcomes

• Amanda J. Wright
• Joshua J. Jackson

Antivirus applied to JAR malware detection based on runtime behaviors

• Ricardo P. Pinheiro
• Sidney M. L. Lima
• Wellington P. dos Santos

Therapeutic enzyme engineering using a generative neural network

• Andrew Giessel
• Athanasios Dousis
• Stuart Licht

Identification of genes associated with human-canine communication in canine evolution

• Akiko Tonoike
• Ken-ichi Otaki
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A Practical Guide to Writing Quantitative and Qualitative Research Questions and Hypotheses in Scholarly Articles

Edward barroga.

1 Department of General Education, Graduate School of Nursing Science, St. Luke’s International University, Tokyo, Japan.

Glafera Janet Matanguihan

2 Department of Biological Sciences, Messiah University, Mechanicsburg, PA, USA.

The development of research questions and the subsequent hypotheses are prerequisites to defining the main research purpose and specific objectives of a study. Consequently, these objectives determine the study design and research outcome. The development of research questions is a process based on knowledge of current trends, cutting-edge studies, and technological advances in the research field. Excellent research questions are focused and require a comprehensive literature search and in-depth understanding of the problem being investigated. Initially, research questions may be written as descriptive questions which could be developed into inferential questions. These questions must be specific and concise to provide a clear foundation for developing hypotheses. Hypotheses are more formal predictions about the research outcomes. These specify the possible results that may or may not be expected regarding the relationship between groups. Thus, research questions and hypotheses clarify the main purpose and specific objectives of the study, which in turn dictate the design of the study, its direction, and outcome. Studies developed from good research questions and hypotheses will have trustworthy outcomes with wide-ranging social and health implications.

INTRODUCTION

Scientific research is usually initiated by posing evidenced-based research questions which are then explicitly restated as hypotheses. 1 , 2 The hypotheses provide directions to guide the study, solutions, explanations, and expected results. 3 , 4 Both research questions and hypotheses are essentially formulated based on conventional theories and real-world processes, which allow the inception of novel studies and the ethical testing of ideas. 5 , 6

It is crucial to have knowledge of both quantitative and qualitative research 2 as both types of research involve writing research questions and hypotheses. 7 However, these crucial elements of research are sometimes overlooked; if not overlooked, then framed without the forethought and meticulous attention it needs. Planning and careful consideration are needed when developing quantitative or qualitative research, particularly when conceptualizing research questions and hypotheses. 4

There is a continuing need to support researchers in the creation of innovative research questions and hypotheses, as well as for journal articles that carefully review these elements. 1 When research questions and hypotheses are not carefully thought of, unethical studies and poor outcomes usually ensue. Carefully formulated research questions and hypotheses define well-founded objectives, which in turn determine the appropriate design, course, and outcome of the study. This article then aims to discuss in detail the various aspects of crafting research questions and hypotheses, with the goal of guiding researchers as they develop their own. Examples from the authors and peer-reviewed scientific articles in the healthcare field are provided to illustrate key points.

DEFINITIONS AND RELATIONSHIP OF RESEARCH QUESTIONS AND HYPOTHESES

A research question is what a study aims to answer after data analysis and interpretation. The answer is written in length in the discussion section of the paper. Thus, the research question gives a preview of the different parts and variables of the study meant to address the problem posed in the research question. 1 An excellent research question clarifies the research writing while facilitating understanding of the research topic, objective, scope, and limitations of the study. 5

On the other hand, a research hypothesis is an educated statement of an expected outcome. This statement is based on background research and current knowledge. 8 , 9 The research hypothesis makes a specific prediction about a new phenomenon 10 or a formal statement on the expected relationship between an independent variable and a dependent variable. 3 , 11 It provides a tentative answer to the research question to be tested or explored. 4

Hypotheses employ reasoning to predict a theory-based outcome. 10 These can also be developed from theories by focusing on components of theories that have not yet been observed. 10 The validity of hypotheses is often based on the testability of the prediction made in a reproducible experiment. 8

Conversely, hypotheses can also be rephrased as research questions. Several hypotheses based on existing theories and knowledge may be needed to answer a research question. Developing ethical research questions and hypotheses creates a research design that has logical relationships among variables. These relationships serve as a solid foundation for the conduct of the study. 4 , 11 Haphazardly constructed research questions can result in poorly formulated hypotheses and improper study designs, leading to unreliable results. Thus, the formulations of relevant research questions and verifiable hypotheses are crucial when beginning research. 12

CHARACTERISTICS OF GOOD RESEARCH QUESTIONS AND HYPOTHESES

Excellent research questions are specific and focused. These integrate collective data and observations to confirm or refute the subsequent hypotheses. Well-constructed hypotheses are based on previous reports and verify the research context. These are realistic, in-depth, sufficiently complex, and reproducible. More importantly, these hypotheses can be addressed and tested. 13

There are several characteristics of well-developed hypotheses. Good hypotheses are 1) empirically testable 7 , 10 , 11 , 13 ; 2) backed by preliminary evidence 9 ; 3) testable by ethical research 7 , 9 ; 4) based on original ideas 9 ; 5) have evidenced-based logical reasoning 10 ; and 6) can be predicted. 11 Good hypotheses can infer ethical and positive implications, indicating the presence of a relationship or effect relevant to the research theme. 7 , 11 These are initially developed from a general theory and branch into specific hypotheses by deductive reasoning. In the absence of a theory to base the hypotheses, inductive reasoning based on specific observations or findings form more general hypotheses. 10

TYPES OF RESEARCH QUESTIONS AND HYPOTHESES

Research questions and hypotheses are developed according to the type of research, which can be broadly classified into quantitative and qualitative research. We provide a summary of the types of research questions and hypotheses under quantitative and qualitative research categories in Table 1 .

Research questions in quantitative research

In quantitative research, research questions inquire about the relationships among variables being investigated and are usually framed at the start of the study. These are precise and typically linked to the subject population, dependent and independent variables, and research design. 1 Research questions may also attempt to describe the behavior of a population in relation to one or more variables, or describe the characteristics of variables to be measured ( descriptive research questions ). 1 , 5 , 14 These questions may also aim to discover differences between groups within the context of an outcome variable ( comparative research questions ), 1 , 5 , 14 or elucidate trends and interactions among variables ( relationship research questions ). 1 , 5 We provide examples of descriptive, comparative, and relationship research questions in quantitative research in Table 2 .

Hypotheses in quantitative research

In quantitative research, hypotheses predict the expected relationships among variables. 15 Relationships among variables that can be predicted include 1) between a single dependent variable and a single independent variable ( simple hypothesis ) or 2) between two or more independent and dependent variables ( complex hypothesis ). 4 , 11 Hypotheses may also specify the expected direction to be followed and imply an intellectual commitment to a particular outcome ( directional hypothesis ) 4 . On the other hand, hypotheses may not predict the exact direction and are used in the absence of a theory, or when findings contradict previous studies ( non-directional hypothesis ). 4 In addition, hypotheses can 1) define interdependency between variables ( associative hypothesis ), 4 2) propose an effect on the dependent variable from manipulation of the independent variable ( causal hypothesis ), 4 3) state a negative relationship between two variables ( null hypothesis ), 4 , 11 , 15 4) replace the working hypothesis if rejected ( alternative hypothesis ), 15 explain the relationship of phenomena to possibly generate a theory ( working hypothesis ), 11 5) involve quantifiable variables that can be tested statistically ( statistical hypothesis ), 11 6) or express a relationship whose interlinks can be verified logically ( logical hypothesis ). 11 We provide examples of simple, complex, directional, non-directional, associative, causal, null, alternative, working, statistical, and logical hypotheses in quantitative research, as well as the definition of quantitative hypothesis-testing research in Table 3 .

Research questions in qualitative research

Unlike research questions in quantitative research, research questions in qualitative research are usually continuously reviewed and reformulated. The central question and associated subquestions are stated more than the hypotheses. 15 The central question broadly explores a complex set of factors surrounding the central phenomenon, aiming to present the varied perspectives of participants. 15

There are varied goals for which qualitative research questions are developed. These questions can function in several ways, such as to 1) identify and describe existing conditions ( contextual research question s); 2) describe a phenomenon ( descriptive research questions ); 3) assess the effectiveness of existing methods, protocols, theories, or procedures ( evaluation research questions ); 4) examine a phenomenon or analyze the reasons or relationships between subjects or phenomena ( explanatory research questions ); or 5) focus on unknown aspects of a particular topic ( exploratory research questions ). 5 In addition, some qualitative research questions provide new ideas for the development of theories and actions ( generative research questions ) or advance specific ideologies of a position ( ideological research questions ). 1 Other qualitative research questions may build on a body of existing literature and become working guidelines ( ethnographic research questions ). Research questions may also be broadly stated without specific reference to the existing literature or a typology of questions ( phenomenological research questions ), may be directed towards generating a theory of some process ( grounded theory questions ), or may address a description of the case and the emerging themes ( qualitative case study questions ). 15 We provide examples of contextual, descriptive, evaluation, explanatory, exploratory, generative, ideological, ethnographic, phenomenological, grounded theory, and qualitative case study research questions in qualitative research in Table 4 , and the definition of qualitative hypothesis-generating research in Table 5 .

Qualitative studies usually pose at least one central research question and several subquestions starting with How or What . These research questions use exploratory verbs such as explore or describe . These also focus on one central phenomenon of interest, and may mention the participants and research site. 15

Hypotheses in qualitative research

Hypotheses in qualitative research are stated in the form of a clear statement concerning the problem to be investigated. Unlike in quantitative research where hypotheses are usually developed to be tested, qualitative research can lead to both hypothesis-testing and hypothesis-generating outcomes. 2 When studies require both quantitative and qualitative research questions, this suggests an integrative process between both research methods wherein a single mixed-methods research question can be developed. 1

FRAMEWORKS FOR DEVELOPING RESEARCH QUESTIONS AND HYPOTHESES

Research questions followed by hypotheses should be developed before the start of the study. 1 , 12 , 14 It is crucial to develop feasible research questions on a topic that is interesting to both the researcher and the scientific community. This can be achieved by a meticulous review of previous and current studies to establish a novel topic. Specific areas are subsequently focused on to generate ethical research questions. The relevance of the research questions is evaluated in terms of clarity of the resulting data, specificity of the methodology, objectivity of the outcome, depth of the research, and impact of the study. 1 , 5 These aspects constitute the FINER criteria (i.e., Feasible, Interesting, Novel, Ethical, and Relevant). 1 Clarity and effectiveness are achieved if research questions meet the FINER criteria. In addition to the FINER criteria, Ratan et al. described focus, complexity, novelty, feasibility, and measurability for evaluating the effectiveness of research questions. 14

The PICOT and PEO frameworks are also used when developing research questions. 1 The following elements are addressed in these frameworks, PICOT: P-population/patients/problem, I-intervention or indicator being studied, C-comparison group, O-outcome of interest, and T-timeframe of the study; PEO: P-population being studied, E-exposure to preexisting conditions, and O-outcome of interest. 1 Research questions are also considered good if these meet the “FINERMAPS” framework: Feasible, Interesting, Novel, Ethical, Relevant, Manageable, Appropriate, Potential value/publishable, and Systematic. 14

As we indicated earlier, research questions and hypotheses that are not carefully formulated result in unethical studies or poor outcomes. To illustrate this, we provide some examples of ambiguous research question and hypotheses that result in unclear and weak research objectives in quantitative research ( Table 6 ) 16 and qualitative research ( Table 7 ) 17 , and how to transform these ambiguous research question(s) and hypothesis(es) into clear and good statements.

a These statements were composed for comparison and illustrative purposes only.

b These statements are direct quotes from Higashihara and Horiuchi. 16

a This statement is a direct quote from Shimoda et al. 17

The other statements were composed for comparison and illustrative purposes only.

CONSTRUCTING RESEARCH QUESTIONS AND HYPOTHESES

To construct effective research questions and hypotheses, it is very important to 1) clarify the background and 2) identify the research problem at the outset of the research, within a specific timeframe. 9 Then, 3) review or conduct preliminary research to collect all available knowledge about the possible research questions by studying theories and previous studies. 18 Afterwards, 4) construct research questions to investigate the research problem. Identify variables to be accessed from the research questions 4 and make operational definitions of constructs from the research problem and questions. Thereafter, 5) construct specific deductive or inductive predictions in the form of hypotheses. 4 Finally, 6) state the study aims . This general flow for constructing effective research questions and hypotheses prior to conducting research is shown in Fig. 1 .

Research questions are used more frequently in qualitative research than objectives or hypotheses. 3 These questions seek to discover, understand, explore or describe experiences by asking “What” or “How.” The questions are open-ended to elicit a description rather than to relate variables or compare groups. The questions are continually reviewed, reformulated, and changed during the qualitative study. 3 Research questions are also used more frequently in survey projects than hypotheses in experiments in quantitative research to compare variables and their relationships.

Hypotheses are constructed based on the variables identified and as an if-then statement, following the template, ‘If a specific action is taken, then a certain outcome is expected.’ At this stage, some ideas regarding expectations from the research to be conducted must be drawn. 18 Then, the variables to be manipulated (independent) and influenced (dependent) are defined. 4 Thereafter, the hypothesis is stated and refined, and reproducible data tailored to the hypothesis are identified, collected, and analyzed. 4 The hypotheses must be testable and specific, 18 and should describe the variables and their relationships, the specific group being studied, and the predicted research outcome. 18 Hypotheses construction involves a testable proposition to be deduced from theory, and independent and dependent variables to be separated and measured separately. 3 Therefore, good hypotheses must be based on good research questions constructed at the start of a study or trial. 12

In summary, research questions are constructed after establishing the background of the study. Hypotheses are then developed based on the research questions. Thus, it is crucial to have excellent research questions to generate superior hypotheses. In turn, these would determine the research objectives and the design of the study, and ultimately, the outcome of the research. 12 Algorithms for building research questions and hypotheses are shown in Fig. 2 for quantitative research and in Fig. 3 for qualitative research.

EXAMPLES OF RESEARCH QUESTIONS FROM PUBLISHED ARTICLES

• EXAMPLE 1. Descriptive research question (quantitative research)
• - Presents research variables to be assessed (distinct phenotypes and subphenotypes)
• “BACKGROUND: Since COVID-19 was identified, its clinical and biological heterogeneity has been recognized. Identifying COVID-19 phenotypes might help guide basic, clinical, and translational research efforts.
• RESEARCH QUESTION: Does the clinical spectrum of patients with COVID-19 contain distinct phenotypes and subphenotypes? ” 19
• EXAMPLE 2. Relationship research question (quantitative research)
• - Shows interactions between dependent variable (static postural control) and independent variable (peripheral visual field loss)
• “Background: Integration of visual, vestibular, and proprioceptive sensations contributes to postural control. People with peripheral visual field loss have serious postural instability. However, the directional specificity of postural stability and sensory reweighting caused by gradual peripheral visual field loss remain unclear.
• Research question: What are the effects of peripheral visual field loss on static postural control ?” 20
• EXAMPLE 3. Comparative research question (quantitative research)
• - Clarifies the difference among groups with an outcome variable (patients enrolled in COMPERA with moderate PH or severe PH in COPD) and another group without the outcome variable (patients with idiopathic pulmonary arterial hypertension (IPAH))
• “BACKGROUND: Pulmonary hypertension (PH) in COPD is a poorly investigated clinical condition.
• RESEARCH QUESTION: Which factors determine the outcome of PH in COPD?
• STUDY DESIGN AND METHODS: We analyzed the characteristics and outcome of patients enrolled in the Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension (COMPERA) with moderate or severe PH in COPD as defined during the 6th PH World Symposium who received medical therapy for PH and compared them with patients with idiopathic pulmonary arterial hypertension (IPAH) .” 21
• EXAMPLE 4. Exploratory research question (qualitative research)
• - Explores areas that have not been fully investigated (perspectives of families and children who receive care in clinic-based child obesity treatment) to have a deeper understanding of the research problem
• “Problem: Interventions for children with obesity lead to only modest improvements in BMI and long-term outcomes, and data are limited on the perspectives of families of children with obesity in clinic-based treatment. This scoping review seeks to answer the question: What is known about the perspectives of families and children who receive care in clinic-based child obesity treatment? This review aims to explore the scope of perspectives reported by families of children with obesity who have received individualized outpatient clinic-based obesity treatment.” 22
• EXAMPLE 5. Relationship research question (quantitative research)
• - Defines interactions between dependent variable (use of ankle strategies) and independent variable (changes in muscle tone)
• “Background: To maintain an upright standing posture against external disturbances, the human body mainly employs two types of postural control strategies: “ankle strategy” and “hip strategy.” While it has been reported that the magnitude of the disturbance alters the use of postural control strategies, it has not been elucidated how the level of muscle tone, one of the crucial parameters of bodily function, determines the use of each strategy. We have previously confirmed using forward dynamics simulations of human musculoskeletal models that an increased muscle tone promotes the use of ankle strategies. The objective of the present study was to experimentally evaluate a hypothesis: an increased muscle tone promotes the use of ankle strategies. Research question: Do changes in the muscle tone affect the use of ankle strategies ?” 23

EXAMPLES OF HYPOTHESES IN PUBLISHED ARTICLES

• EXAMPLE 1. Working hypothesis (quantitative research)
• - A hypothesis that is initially accepted for further research to produce a feasible theory
• “As fever may have benefit in shortening the duration of viral illness, it is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response when taken during the early stages of COVID-19 illness .” 24
• “In conclusion, it is plausible to hypothesize that the antipyretic efficacy of ibuprofen may be hindering the benefits of a fever response . The difference in perceived safety of these agents in COVID-19 illness could be related to the more potent efficacy to reduce fever with ibuprofen compared to acetaminophen. Compelling data on the benefit of fever warrant further research and review to determine when to treat or withhold ibuprofen for early stage fever for COVID-19 and other related viral illnesses .” 24
• EXAMPLE 2. Exploratory hypothesis (qualitative research)
• - Explores particular areas deeper to clarify subjective experience and develop a formal hypothesis potentially testable in a future quantitative approach
• “We hypothesized that when thinking about a past experience of help-seeking, a self distancing prompt would cause increased help-seeking intentions and more favorable help-seeking outcome expectations .” 25
• “Conclusion
• Although a priori hypotheses were not supported, further research is warranted as results indicate the potential for using self-distancing approaches to increasing help-seeking among some people with depressive symptomatology.” 25
• EXAMPLE 3. Hypothesis-generating research to establish a framework for hypothesis testing (qualitative research)
• “We hypothesize that compassionate care is beneficial for patients (better outcomes), healthcare systems and payers (lower costs), and healthcare providers (lower burnout). ” 26
• Compassionomics is the branch of knowledge and scientific study of the effects of compassionate healthcare. Our main hypotheses are that compassionate healthcare is beneficial for (1) patients, by improving clinical outcomes, (2) healthcare systems and payers, by supporting financial sustainability, and (3) HCPs, by lowering burnout and promoting resilience and well-being. The purpose of this paper is to establish a scientific framework for testing the hypotheses above . If these hypotheses are confirmed through rigorous research, compassionomics will belong in the science of evidence-based medicine, with major implications for all healthcare domains.” 26
• EXAMPLE 4. Statistical hypothesis (quantitative research)
• - An assumption is made about the relationship among several population characteristics ( gender differences in sociodemographic and clinical characteristics of adults with ADHD ). Validity is tested by statistical experiment or analysis ( chi-square test, Students t-test, and logistic regression analysis)
• “Our research investigated gender differences in sociodemographic and clinical characteristics of adults with ADHD in a Japanese clinical sample. Due to unique Japanese cultural ideals and expectations of women's behavior that are in opposition to ADHD symptoms, we hypothesized that women with ADHD experience more difficulties and present more dysfunctions than men . We tested the following hypotheses: first, women with ADHD have more comorbidities than men with ADHD; second, women with ADHD experience more social hardships than men, such as having less full-time employment and being more likely to be divorced.” 27
• “Statistical Analysis
• ( text omitted ) Between-gender comparisons were made using the chi-squared test for categorical variables and Students t-test for continuous variables…( text omitted ). A logistic regression analysis was performed for employment status, marital status, and comorbidity to evaluate the independent effects of gender on these dependent variables.” 27

EXAMPLES OF HYPOTHESIS AS WRITTEN IN PUBLISHED ARTICLES IN RELATION TO OTHER PARTS

• EXAMPLE 1. Background, hypotheses, and aims are provided
• “Pregnant women need skilled care during pregnancy and childbirth, but that skilled care is often delayed in some countries …( text omitted ). The focused antenatal care (FANC) model of WHO recommends that nurses provide information or counseling to all pregnant women …( text omitted ). Job aids are visual support materials that provide the right kind of information using graphics and words in a simple and yet effective manner. When nurses are not highly trained or have many work details to attend to, these job aids can serve as a content reminder for the nurses and can be used for educating their patients (Jennings, Yebadokpo, Affo, & Agbogbe, 2010) ( text omitted ). Importantly, additional evidence is needed to confirm how job aids can further improve the quality of ANC counseling by health workers in maternal care …( text omitted )” 28
• “ This has led us to hypothesize that the quality of ANC counseling would be better if supported by job aids. Consequently, a better quality of ANC counseling is expected to produce higher levels of awareness concerning the danger signs of pregnancy and a more favorable impression of the caring behavior of nurses .” 28
• “This study aimed to examine the differences in the responses of pregnant women to a job aid-supported intervention during ANC visit in terms of 1) their understanding of the danger signs of pregnancy and 2) their impression of the caring behaviors of nurses to pregnant women in rural Tanzania.” 28
• EXAMPLE 2. Background, hypotheses, and aims are provided
• “We conducted a two-arm randomized controlled trial (RCT) to evaluate and compare changes in salivary cortisol and oxytocin levels of first-time pregnant women between experimental and control groups. The women in the experimental group touched and held an infant for 30 min (experimental intervention protocol), whereas those in the control group watched a DVD movie of an infant (control intervention protocol). The primary outcome was salivary cortisol level and the secondary outcome was salivary oxytocin level.” 29
• “ We hypothesize that at 30 min after touching and holding an infant, the salivary cortisol level will significantly decrease and the salivary oxytocin level will increase in the experimental group compared with the control group .” 29
• EXAMPLE 3. Background, aim, and hypothesis are provided
• “In countries where the maternal mortality ratio remains high, antenatal education to increase Birth Preparedness and Complication Readiness (BPCR) is considered one of the top priorities [1]. BPCR includes birth plans during the antenatal period, such as the birthplace, birth attendant, transportation, health facility for complications, expenses, and birth materials, as well as family coordination to achieve such birth plans. In Tanzania, although increasing, only about half of all pregnant women attend an antenatal clinic more than four times [4]. Moreover, the information provided during antenatal care (ANC) is insufficient. In the resource-poor settings, antenatal group education is a potential approach because of the limited time for individual counseling at antenatal clinics.” 30
• “This study aimed to evaluate an antenatal group education program among pregnant women and their families with respect to birth-preparedness and maternal and infant outcomes in rural villages of Tanzania.” 30
• “ The study hypothesis was if Tanzanian pregnant women and their families received a family-oriented antenatal group education, they would (1) have a higher level of BPCR, (2) attend antenatal clinic four or more times, (3) give birth in a health facility, (4) have less complications of women at birth, and (5) have less complications and deaths of infants than those who did not receive the education .” 30

Research questions and hypotheses are crucial components to any type of research, whether quantitative or qualitative. These questions should be developed at the very beginning of the study. Excellent research questions lead to superior hypotheses, which, like a compass, set the direction of research, and can often determine the successful conduct of the study. Many research studies have floundered because the development of research questions and subsequent hypotheses was not given the thought and meticulous attention needed. The development of research questions and hypotheses is an iterative process based on extensive knowledge of the literature and insightful grasp of the knowledge gap. Focused, concise, and specific research questions provide a strong foundation for constructing hypotheses which serve as formal predictions about the research outcomes. Research questions and hypotheses are crucial elements of research that should not be overlooked. They should be carefully thought of and constructed when planning research. This avoids unethical studies and poor outcomes by defining well-founded objectives that determine the design, course, and outcome of the study.

Disclosure: The authors have no potential conflicts of interest to disclose.

Author Contributions:

• Conceptualization: Barroga E, Matanguihan GJ.
• Methodology: Barroga E, Matanguihan GJ.
• Writing - original draft: Barroga E, Matanguihan GJ.
• Writing - review & editing: Barroga E, Matanguihan GJ.

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Stigmatizing Language, Patient Demographics, and Errors in the Diagnostic Process

• 1 Division of Hospital Medicine, Department of Medicine, University of California, San Francisco, San Francisco General Hospital, San Francisco
• 2 Division of Hospital Medicine, Denver Health, University of Colorado, Denver
• 3 Division of Hospital Medicine, Department of Medicine, University of Colorado, Denver
• 4 Division of Hospital Medicine, Department of Medicine, University of California, San Francisco
• Medical News in Brief Study: Stigma in Medical Records Tied to Diagnostic Errors Emily Harris JAMA

Stigmatizing language (SL) is widespread throughout medical documentation. 1 It is more likely to be found in the records of Black patients, 2 , 3 patients with public insurance, 2 and patients with certain comorbidities. 3 We investigated associations between SL, errors in the diagnostic process, and demographics for hospitalized patients.

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Brooks KC , Raffel KE , Chia D, et al. Stigmatizing Language, Patient Demographics, and Errors in the Diagnostic Process. JAMA Intern Med. 2024;184(6):704–706. doi:10.1001/jamainternmed.2024.0705

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Wenbo Wu , Zhongwen Zhan , Mark Panning , Andrew Klesh; Fiber Seismic Network on the Moon. Seismological Research Letters 2024;; 95 (4): 2153–2163. doi: https://doi.org/10.1785/0220230067

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Internal structures of the Moon are key to understanding the origin and evolution of the Earth–Moon system and other planets. The Apollo Passive Seismic Experiment detected thousands of lunar seismic events and vastly improved our understanding of the Moon’s interior. However, some critical questions like the state and composition of the core remain unsolved largely due to the sparsity of the Apollo seismic stations and the strong scattering of seismic waves in the top layer of the Moon. In this study, we propose the concept of a fiber seismic network on the Moon and discuss its potential in overcoming the challenges in imaging deep Moon structures. As an emerging technique, distributed acoustic sensing (DAS) can provide a cost‐efficient solution for large‐aperture and dense seismic network deployment in harsh environments. We compute lunar synthetic seismograms and evaluate the performance of DAS arrays of different configurations in retrieving the hidden core reflected seismic phase ScS from the strong scattered waves. We find that, compared to a sparse conventional seismic network, a fiber seismic network using tens of kilometers of cable can dramatically increase the chance of observing clear ScS by array stacking. Our results indicate that DAS could provide new opportunities for the future lunar seismic surveys, but more efforts and further evaluations are required to develop a space‐proof DAS.

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• acoustical methods
• deformation
• elastic waves
• geophysical methods
• guided waves
• lunar interior
• receiver functions
• seismic networks
• seismic waves
• surface waves
• fiber optics
• distributed acoustic sensing
• lunar seismicity

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Traffic engineers build roads that invite crashes because they rely on outdated research and faulty data

Professor of Civil Engineering, University of Colorado Denver

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Wes Marshall receives funding from the US Department of Transportation's University Transportation Centers program and various state transportation departments.

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“Can you name the truck with four-wheel drive, smells like a steak, and seats 35?”

Back in 1998, “The Simpsons” joked about the Canyonero, an SUV so big that they were obviously kidding. At that time, it was preposterous to think anyone would drive something that was “12 yards long, two lanes wide, 65 tons of American Pride.”

In 2024, that joke isn’t far from reality.

And our reality is one where more pedestrians and bicyclists are getting killed on U.S. streets than at any time in the past 45 years – over 1,000 bicyclists and 7,500 pedestrians in 2022 alone.

Vehicle size is a big part of this problem. A recent paper by urban economist Justin Tyndall found that increasing the front-end height of a vehicle by roughly 4 inches (10 centimeters) increases the chance of a pedestrian fatality by 22% . The risk increases by 31% for female pedestrians or those over 65 years, and by 81% for children.

It’s hard to argue with physics, so there is a certain logic in blaming cars for rising traffic deaths. In fact, if a bicyclist is hit by a pickup truck instead of a car, Tyndall suggests that they are 291% more likely to die.

Yet automakers have long asserted that if everyone simply followed the rules of the road, nobody would die. Vehicle size is irrelevant to that assertion.

My discipline, traffic engineering , acts similarly. We underestimate our role in perpetuating bad outcomes, as well as the role that better engineering can play in designing safer communities and streets.

Millions of road deaths

How bad are the bad outcomes? The U.S. has been tracking car-related road deaths since 1899. As a country, we hit the threshold of 1 million cumulative deaths in 1953, 2 million in 1975 and 3 million in 1998. While the past several years of data have not yet been released, I estimate that the U.S. topped 4 million total road deaths sometime in the spring of 2024.

How many of those are pedestrians and bicyclists? Analysts didn’t do a great job of separating out the pedestrian and cyclist deaths in the early years , but based on later trends, my estimate is that some 930,000 pedestrians and bicyclists have been killed by automobiles in the U.S.

How many of those deaths do we blame on big cars or bad streets? The answer is, very few.

As I show in my new book, “ Killed by a Traffic Engineer: Shattering the Delusion that Science Underlies our Transportation System ,” the National Highway Traffic Safety Administration calls road user error the “ critical reason” behind 94% of crashes, injuries and deaths .

Crash data backs that up.

Police investigate crashes and inevitably look to see which road users, including drivers, pedestrians and cyclists, are most at fault. It’s easy to do because in almost any crash, road user error appears to be the obvious problem.

This approach helps insurance companies figure out who needs to pay. It also helps automakers and traffic engineers rationalize away all these deaths. Everyone – except the families and friends of these 4 million victims – goes to sleep at night feeling good that bad-behaving road users just need more education or better enforcement.

But road user error only scratches the surface of the problem.

Who creates dangerous streets?

When traffic engineers build an overly wide street that looks more like a freeway , and a speeding driver in a Canyonero crashes, subsequent crash data blames the driver for speeding.

When traffic engineers provide lousy crosswalks separated by long distances , and someone jaywalks and gets hit by that speeding Canyonero driver, one or both of these road users will be blamed in the official crash report.

And when automakers build gargantuan vehicles that can easily go double the speed limit and fill them with distracting touchscreens , crash data will still blame the road users for almost anything bad that happens.

These are the sorts of systemic conditions that lead to many so-called road user errors. Look just below the surface, though, and it becomes clear that many human errors represent the typical, rational behaviors of typical, rational road users given the transportation system and vehicle options we put in front of them.

Look more deeply, and you can start to see how our underlying crash data gives everyone a pass but the road users themselves. Everyone wants a data-driven approach to road safety, but today’s standard view of crash data lets automakers, insurance companies and policymakers who shape vehicle safety standards off the hook for embiggening these ever-larger cars and light-duty trucks.

It also absolves traffic engineers, planners and policymakers of blame for creating a transportation system where for most Americans, the only rational choice for getting around is a car .

Understanding road behavior

Automakers want to sell cars and make money. And if bigger SUVs seem safer to potential customers, while also being much more profitable , it’s easy to see how interactions between road users and car companies – making seemingly rational decisions – have devolved into an SUV arms race.

Even though these same vehicles are less safe for pedestrians, bicyclists and those in opposing vehicles , the current data-driven approach to road safety misses that part of the story.

This can’t all be fixed at once. But by pursuing business as usual, automakers and traffic engineers will continue wasting money on victim-blaming campaigns or billboards placed high over a road telling drivers to pay attention to the road .

A better starting point would be remaking the U.S.’s allegedly data-driven approach to road safety by reinventing our understanding of the crash data that informs it all.

The key is starting to ask why. Why did these road users act as they did? Why didn’t they follow the rules that were laid out for them? Bad road user behavior shouldn’t be excused, but a bit of digging below the surface of crash data unearths a completely different story.

Figuring out which road user is most at fault may be useful for law enforcement and insurance companies, but it doesn’t give transportation engineers, planners, policymakers or automakers much insight into what they can do better. Even worse, it has kept them from realizing that they might be doing anything wrong.

• Urban policy
• Civil engineering
• Pedestrians
• Car accidents
• Sustainable cities
• Transportation policy
• Safe streets
• Bicycle safety
• Motorcycles

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Scientific breakthroughs: 2024 emerging trends to watch

December 28, 2023

Across disciplines and industries, scientific discoveries happen every day, so how can you stay ahead of emerging trends in a thriving landscape? At CAS, we have a unique view of recent scientific breakthroughs, the historical discoveries they were built upon, and the expertise to navigate the opportunities ahead. In 2023, we identified the top scientific breakthroughs , and 2024 has even more to offer. New trends to watch include the accelerated expansion of green chemistry, the clinical validation of CRISPR, the rise of biomaterials, and the renewed progress in treating the undruggable, from cancer to neurodegenerative diseases. To hear what the experts from Lawrence Liverpool National Lab and Oak Ridge National Lab are saying on this topic, join us for a free webinar on January 25 from 10:00 to 11:30 a.m. EDT for a panel discussion on the trends to watch in 2024.

The ascension of AI in R&D

While the future of AI has always been forward-looking, the AI revolution in chemistry and drug discovery has yet to be fully realized. While there have been some high-profile set-backs , several breakthroughs should be watched closely as the field continues to evolve. Generative AI is making an impact in drug discovery , machine learning is being used more in environmental research , and large language models like ChatGPT are being tested in healthcare applications and clinical settings.

Many scientists are keeping an eye on AlphaFold, DeepMind’s protein structure prediction software that revolutionized how proteins are understood. DeepMind and Isomorphic Labs have recently announced how their latest model shows improved accuracy, can generate predictions for almost all molecules in the Protein Data Bank, and expand coverage to ligands, nucleic acids, and posttranslational modifications . Therapeutic antibody discovery driven by AI is also gaining popularity , and platforms such as the RubrYc Therapeutics antibody discovery engine will help advance research in this area.

Though many look at AI development with excitement, concerns over accurate and accessible training data , fairness and bias , lack of regulatory oversight , impact on academia, scholarly research and publishing , hallucinations in large language models , and even concerns over infodemic threats to public health are being discussed. However, continuous improvement is inevitable with AI, so expect to see many new developments and innovations throughout 2024.

‘Greener’ green chemistry

Green chemistry is a rapidly evolving field that is constantly seeking innovative ways to minimize the environmental impact of chemical processes. Here are several emerging trends that are seeing significant breakthroughs:

• Improving green chemistry predictions/outcomes : One of the biggest challenges in green chemistry is predicting the environmental impact of new chemicals and processes. Researchers are developing new computational tools and models that can help predict these impacts with greater accuracy. This will allow chemists to design safer and more environmentally friendly chemicals.
• Reducing plastics: More than 350 million tons of plastic waste is generated every year. Across the landscape of manufacturers, suppliers, and retailers, reducing the use of single-use plastics and microplastics is critical. New value-driven approaches by innovators like MiTerro that reuse industrial by-products and biomass waste for eco-friendly and cheaper plastic replacements will soon be industry expectations. Lowering costs and plastic footprints will be important throughout the entire supply chain.    
• Alternative battery chemistry: In the battery and energy storage space, finding alternatives to scarce " endangered elements" like lithium and cobalt will be critical. While essential components of many batteries, they are becoming scarce and expensive. New investments in lithium iron phosphate (LFP) batteries that do not use nickel and cobalt have expanded , with 45% of the EV market share being projected for LFP in 2029. Continued research is projected for more development in alternative materials like sodium, iron, and magnesium, which are more abundant, less expensive, and more sustainable.
• More sustainable catalysts : Catalysts speed up a chemical reaction or decrease the energy required without getting consumed. Noble metals are excellent catalysts; however, they are expensive and their mining causes environmental damage. Even non-noble metal catalysts can also be toxic due to contamination and challenges with their disposal. Sustainable catalysts are made of earth-abundant elements that are also non-toxic in nature. In recent years, there has been a growing focus on developing sustainable catalysts that are more environmentally friendly and less reliant on precious metals. New developments with catalysts, their roles, and environmental impact will drive meaningful progress in reducing carbon footprints.  
• Recycling lithium-ion batteries: Lithium-ion recycling has seen increased investments with more than 800 patents already published in 2023. The use of solid electrolytes or liquid nonflammable electrolytes may improve the safety and durability of LIBs and reduce their material use. Finally, a method to manufacture electrodes without solvent s could reduce the use of deprecated solvents such as N-methylpyrrolidinone, which require recycling and careful handling to prevent emissions.

Rise of biomaterials

New materials for biomedical applications could revolutionize many healthcare segments in 2024. One example is bioelectronic materials, which form interfaces between electronic devices and the human body, such as the brain-computer interface system being developed by Neuralink. This system, which uses a network of biocompatible electrodes implanted directly in the brain, was given FDA approval to begin human trials in 2023.

• Bioelectronic materials: are often hybrids or composites, incorporating nanoscale materials, highly engineered conductive polymers, and bioresorbable substances. Recently developed devices can be implanted, used temporarily, and then safely reabsorbed by the body without the need for removal. This has been demonstrated by a fully bioresorbable, combined sensor-wireless power receiver made from zinc and the biodegradable polymer, poly(lactic acid).
• Natural biomaterials: that are biocompatible and naturally derived (such as chitosan, cellulose nanomaterials, and silk) are used to make advanced multifunctional biomaterials in 2023. For example, they designed an injectable hydrogel brain implant for treating Parkinson’s disease, which is based on reversible crosslinks formed between chitosan, tannic acid, and gold nanoparticles.
• Bioinks : are used for 3D printing of organs and transplant development which could revolutionize patient care. Currently, these models are used for studying organ architecture like 3D-printed heart models for cardiac disorders and 3D-printed lung models to test the efficacy of drugs. Specialized bioinks enhance the quality, efficacy, and versatility of 3D-printed organs, structures, and outcomes. Finally, new approaches like volumetric additive manufacturing (VAM) of pristine silk- based bioinks are unlocking new frontiers of innovation for 3D printing.

To the moon and beyond

The global Artemis program is a NASA-led international space exploration program that aims to land the first woman and the first person of color on the Moon by 2025 as part of the long-term goal of establishing a sustainable human presence on the Moon. Additionally, the NASA mission called Europa Clipper, scheduled for a 2024 launch, will orbit around Jupiter and fly by Europa , one of Jupiter’s moons, to study the presence of water and its habitability. China’s mission, Chang’e 6 , plans to bring samples from the moon back to Earth for further studies. The Martian Moons Exploration (MMX) mission by Japan’s JAXA plans to bring back samples from Phobos, one of the Mars moons. Boeing is also expected to do a test flight of its reusable space capsule Starliner , which can take people to low-earth orbit.

The R&D impact of Artemis extends to more fields than just aerospace engineering, though:

• Robotics: Robots will play a critical role in the Artemis program, performing many tasks, such as collecting samples, building infrastructure, and conducting scientific research. This will drive the development of new robotic technologies, including autonomous systems and dexterous manipulators.
• Space medicine: The Artemis program will require the development of new technologies to protect astronauts from the hazards of space travel, such as radiation exposure and microgravity. This will include scientific discoveries in medical diagnostics, therapeutics, and countermeasures.
• Earth science: The Artemis program will provide a unique opportunity to study the Moon and its environment. This will lead to new insights into the Earth's history, geology, and climate.
• Materials science: The extreme space environment will require new materials that are lightweight, durable, and radiation resistant. This will have applications in many industries, including aerospace, construction, and energy.
• Information technology: The Artemis program will generate a massive amount of data, which will need to be processed, analyzed, and shared in real time. This will drive the development of new IT technologies, such as cloud computing, artificial intelligence, and machine learning.

The CRISPR pay-off

After years of research, setbacks, and minimal progress, the first formal evidence of CRISPR as a therapeutic platform technology in the clinic was realized. Intellia Therapeutics received FDA clearance to initiate a pivotal phase 3 trial of a new drug for the treatment of hATTR, and using the same Cas9 mRNA, got a new medicine treating a different disease, angioedema. This was achieved by only changing 20 nucleotides of the guide RNA, suggesting that CRISPR can be used as a therapeutic platform technology in the clinic.

The second great moment for CRISPR drug development technology came when Vertex and CRISPR Therapeutics announced the authorization of the first CRISPR/Cas9 gene-edited therapy, CASGEVY™, by the United Kingdom MHRA, for the treatment of sickle cell disease and transfusion-dependent beta-thalassemia. This was the first approval of a CRISPR-based therapy for human use and is a landmark moment in realizing the potential of CRISPR to improve human health.

In addition to its remarkable genome editing capability, the CRISPR-Cas system has proven to be effective in many applications, including early cancer diagnosis . CRISPR-based genome and transcriptome engineering and CRISPR-Cas12a and CRISPR-Cas13a appear to have the necessary characteristics to be robust detection tools for cancer therapy and diagnostics. CRISPR-Cas-based biosensing system gives rise to a new era for precise diagnoses of early-stage cancers.

MIT engineers have also designed a new nanoparticle DNA-encoded nanosensor for urinary biomarkers that could enable early cancer diagnoses with a simple urine test. The sensors, which can detect cancerous proteins, could also distinguish the type of tumor or how it responds to treatment.

Ending cancer

The immuno-oncology field has seen tremendous growth in the last few years. Approved products such as cytokines, vaccines, tumor-directed monoclonal antibodies, and immune checkpoint blockers continue to grow in market size. Novel therapies like TAC01-HER2 are currently undergoing clinical trials. This unique therapy uses autologous T cells, which have been genetically engineered to incorporate T cell Antigen Coupler (TAC) receptors that recognize human epidermal growth factor receptor 2 (HER2) presence on tumor cells to remove them. This could be a promising therapy for metastatic, HER2-positive solid tumors.

Another promising strategy aims to use the CAR-T cells against solid tumors in conjunction with a vaccine that boosts immune response. Immune boosting helps the body create more host T cells that can target other tumor antigens that CAR-T cells cannot kill.

Another notable trend is the development of improved and effective personalized therapies. For instance, a recently developed personalized RNA neoantigen vaccine, based on uridine mRNA–lipoplex nanoparticles, was found effective against pancreatic ductal adenocarcinoma (PDAC). Major challenges in immuno-oncology are therapy resistance, lack of predictable biomarkers, and tumor heterogenicity. As a result, devising novel treatment strategies could be a future research focus.

Decarbonizing energy

Multiple well-funded efforts are underway to decarbonize energy production by replacing fossil fuel-based energy sources with sources that generate no (or much less) CO2 in 2024.

One of these efforts is to incorporate large-scale energy storage devices into the existing power grid. These are an important part of enabling the use of renewable sources since they provide additional supply and demand for electricity to complement renewable sources. Several types of grid-scale storage that vary in the amount of energy they can store and how quickly they can discharge it into the grid are under development. Some are physical (flywheels, pumped hydro, and compressed air) and some are chemical (traditional batteries, flow batteries , supercapacitors, and hydrogen ), but all are the subject of active chemistry and materials development research. The U.S. government is encouraging development in this area through tax credits as part of the Inflation Reduction Act and a $7 billion program to establish regional hydrogen hubs.

Meanwhile, nuclear power will continue to be an active R&D area in 2024. In nuclear fission, multiple companies are developing small modular reactors (SMRs) for use in electricity production and chemical manufacturing, including hydrogen. The development of nuclear fusion reactors involves fundamental research in physics and materials science. One major challenge is finding a material that can be used for the wall of the reactor facing the fusion plasma; so far, candidate materials have included high-entropy alloys and even molten metals .

Neurodegenerative diseases

Neurodegenerative diseases are a major public health concern, being a leading cause of death and disability worldwide. While there is currently no cure for any neurodegenerative disease, new scientific discoveries and understandings of these pathways may be the key to helping patient outcomes.

• Alzheimer’s disease: Two immunotherapeutics have received FDA approval to reduce both cognitive and functional decline in individuals living with early Alzheimer's disease. Aducannumab (Aduhelm®) received accelerated approval in 2021 and is the first new treatment approved for Alzheimer’s since 2003 and the first therapy targeting the disease pathophysiology, reducing beta-amyloid plaques in the brains of early Alzheimer’s disease patients. Lecanemab (Leqembi®) received traditional approval in 2023 and is the first drug targeting Alzheimer’s disease pathophysiology to show clinical benefits, reducing the rate of disease progression and slowing cognitive and functional decline in adults with early stages of the disease.
• Parkinson’s disease: New treatment modalities outside of pharmaceuticals and deep brain stimulation are being researched and approved by the FDA for the treatment of Parkinson’s disease symptoms. The non-invasive medical device, Exablate Neuro (approved by the FDA in 2021), uses focused ultrasound on one side of the brain to provide relief from severe symptoms such as tremors, limb rigidity, and dyskinesia. 2023 brought major news for Parkinson’s disease research with the validation of the biomarker alpha-synuclein. Researchers have developed a tool called the α-synuclein seeding amplification assay which detects the biomarker in the spinal fluid of people diagnosed with Parkinson’s disease and individuals who have not shown clinical symptoms.
• Amyotrophic lateral sclerosis (ALS): Two pharmaceuticals have seen FDA approval in the past two years to slow disease progression in individuals with ALS. Relyvrio ® was approved in 2022 and acts by preventing or slowing more neuron cell death in patients with ALS. Tofersen (Qalsody®), an antisense oligonucleotide, was approved in 2023 under the accelerated approval pathway. Tofersen targets RNA produced from mutated superoxide dismutase 1 (SOD1) genes to eliminate toxic SOD1 protein production. Recently published genetic research on how mutations contribute to ALS is ongoing with researchers recently discovering how NEK1 gene mutations lead to ALS. This discovery suggests a possible rational therapeutic approach to stabilizing microtubules in ALS patients.

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