• Must speak, read and write English well
• Valid passport
• Clean criminal record
Apply for the MBBS program at SUMC .
NJMU is located in Nanjing, a city rich in Chinese history and culture. The medical university has two campuses: Wutai and Jiangning. The MBBS program takes 6 years to complete, with only 100 students enrolled for the intake. Students can do their internship in any of the following facilities:
– The First Affiliated Hospital of NMU – The Second Affiliated Hospital of NMU – Nanjing First Hospital – Nanjing Drum Tower Hospital
September every year (only one intake per year) * | |
End of June | |
• Must be 18 to 25 years old • Must of good physical and mental health • Outstanding grades | |
US$5,252 per year | |
Jasmine Jiangsu Government Scholarship |
*The application can be closed earlier if the targeted number of students is reached earlier. Feedback for the application is usually given within 4 to 6 weeks after application.
Apply for the MBBS program at NJMU .
In Hangzhou, one of the most visited places by tourist, lies Zhejiang University. The School of Medicine offers an MBBS program that is recognized internationally. The program takes 6 years to complete including 5 years of classroom teaching and 1 year of internship.
As a student, you will go through three stages of the course which include:
– Pre-med for 1 year – Pre-clinic for 2 years – Clinic for 3 years – Internship for 1 year (you will be supervised by doctors)
September every year (only one intake per year) | |
Mid-July | |
• Must be 18 to 25 years old • Must of good physical and mental health • Outstanding grades | |
US$6,619 per year | |
Chinese Government Scholarship |
Apply for the MBBS program at Zhejiang University .
Shanghai Medical College is part of Fudan University, one of the oldest and most prestigious universities in China. SHMC is located in Xujiahui, a commercial district in Shanghai. The MBBS program at SHMC takes 6 years to complete.
You can choose to do your internship in China, your home country or another country. The school will help you find a suitable hospital to do your internship.
If you choose to do your internship in China, you must pass HSK 5 before the internship so that you can communicate with patients effectively. Some hospitals affiliated with Shanghai Medical College include:
– Huadong Hospital – Shanghai Cancer Center – Eye and ENT hospital – Shanghai Public Health Clinical Center
September every year (only one intake per year) | |
Mid-July | |
• Native English speaker • Studied a degree in English before • Have passed IELTS level 6, TOEFL qualification | |
US$11,598 per year | |
Outstanding Foreign Student Scholarship |
Apply for the MBBS program at Fudan University .
Guangzhou Medical University is located in Guangzhou, one of the three largest cities in China. It has an amazing campus that is suitable teachers and students. The MBBS program at GMU takes 6 years to complete.
September every year | |
First week of July | |
• Non-Chinese citizen • Good physical and mental health • High school graduate | |
US$4,639 per year | |
Chinese Government Scholarship Guangzhou Government Scholarship |
Apply for the MBBS program at GMU .
Capital Medical University is located in Beijing, China. CCMU has one of the most advanced equipment and international faculty of 994 associate professors and 548 professors. The MBBS at CCMU takes 6 years to complete:
– 1 year of foundation – 2 years of basic medicine – 2 years of clinical medicine – 1 year internship
Students can do their internship in the 14 hospitals the university is affiliated with. CCMU has outstanding reputation in scientific research including traditional Chinese medicine and basic medicine.
CCMU also has partnerships with international education institutions in more than 20 countries and many student exchange programs.
September every year | |
First week of June | |
• Pre-med course which takes 1 semester to complete (2 intakes, March and in June) • Must be between 18 to 40 years old • High school graduate • Must be English proficient | |
US$7,732 per year | |
Beijing Government Scholarship |
Apply for the MBBS program at CCMU .
Tongji University School of Management is located in Shanghai, the financial capital of China. The MBBS at TUSM takes 6 years to complete.
At TUSM, you will study with dedicated faculty members, undertake research and clinical rotations with national top research teams and affiliated hospitals, and receive a globally recognized medical degree.
You will also enjoy a dynamic campus life and meet students from all over the world. TUSM’s ultimate goal is to train doctors who are competent in the delivery of effective and ethical medical care in today’s rapidly changing health-care environment.
September every year | |
May | |
• Have passed IELTS level 6, TOEFL qualification • Must be between 18 to 25 years old • High school graduate | |
US$6,959per year | |
Entry Scholarship Dean Scholarship Tongji Presidential Scholarship Shanghai Government Scholarship (Class C) |
Apply for the MBBS program at TUSM .
Jinzhou Medical University is located in northeastern China in the city of Jinzhou. The MBBS program at JZMU takes 6 years to complete, inclusive of one year of internship. Internship is done at the First Affiliated Hospital of Liaoning Medical University (LMU).
September every year | |
End of August | |
• Physically and mentally fit • Must be between 18 to 25 years old • High school graduateNo criminal record | |
US$5,412 per year | |
Chinese Government Scholarships |
Apply for the MBBS program at JZMU .
Studying MBBS in China is something you will never regret. Read our MBBS guide , choose a university, apply for the next MBBS intake and get your medical career started.
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Medical education refers to education related to the practice of being a medical practitioner those who follow basic medical training become a physician, additional trainings allow medical student to specialize in one of medical area. Modern Medical Education in China started in the early 20th century. Medical Universities, Colleges and Schools accredited by China higher education council, offer six years undergraduate medical education. To control standards of medical education in china, Chinese Ministry of Education set up a quality control regulation on medical education, this regulation gives special attention to English medium for undergraduate students. At the present, there are around 50 Medical Universities and schools have been accredited to offer MBBS and BDS program in English medium, where foreign students who meet entry criteria, apply to study in those universities and schools.
Medical Education in China have been improved in order to meet international standards, today most Chinese medical schools offer MBBS, BDS programs taught in English medium language. Medical student who completed MBBS medical education program awarded MBBS degree, however the one who followed BDS medical education program awarded BDS degree. In Most of Medical Universities/schools or colleges in China admit students in MBBS or BDS programs with science subject’s background such as Mathematics, Biology, Chemistry, and Physics. Students must prove that they can follow medical courses in English. Those subjects are pre-requisite for being accepted to any Chinese medical schools other requirements vary by medical school. Furthermore apart from MBBS and BDS program, China Medical education system train postgraduate students in all medical fields at Masters as well as for Doctorate levels, masters in any clinical field last 3 years in most Chinese medical schools, and Doctorate last 3-4 years in most medical education institutions in china.
Today Chinese medical universities and schools, first courses focused on basic sciences such as Anatomy, Physiology, Biochemistry, Pharmacology and Pathology. In advanced years, students cover clinical medicine subjects like Pediatrics, Obstetrics and Gynecology, Internal medicine, Psychiatry, Public health and General surgery. Those courses are for the student who undergoes MBBS program, after 5 years coursework, the medical students start their internship in one of the hospital affiliated to his/her medical university/school. The successful completion of internship allow medical student to be awarded Bachelor of Medicine, Bachelor of Surgery degree. Starting practice medical career after MBBS degree depends on the laws and regulations of the country where a graduate student want to exercise his/her medical career.
Other medical education program offered by most of medical universities/ schools in China is BDS program. BDS medical education train skilled medical personnel who want to become medical Dentist. At the present BDS program is among the most preferable medical education program in China by foreign students.
BDS curriculum has recently reviewed in order to meet international standards and provide a solid medical background in modern dental field. The core courses in BDS medical education in China include oral pathology, oral medicine, Human oral anatomy, Oral microbiology, Materials used in Dentistry, Histology and Tooth Morphology , Maxillofacial surgery. All those subjects are taught in English. BDS medical education in China takes 5 years including internship. A successful completion of BDS medical education allows a medical student to be awarded Bachelor of Dentistry and dental Surgery degree. Starting practice as a dentist and dental surgical operations depend on the laws and regulations of where BDS degree owner want to exercise his/her career.
Medical Education in China continues to be successful and produce skilled future Doctors, because of having experienced and carrier devoted professors/teachers. Modern infrastructure and use of modern technology in medical education make China medical education to be among the best around the world. Most of Chinese Medical universities, schools and colleges are recognized by World Health Organization and China Medical education is ranked at 4th by recent WHO survey, Medical degrees provided by Chinese Medical universities/schools and college are accepted and recognized all over the world. Those degrees allow a graduate who want to pursue major or minor medical specialties in any Medical university/school or colleges all over the world.
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Pursuing a medical degree can be an expensive endeavour, but several countries abroad offer quality medical education at a fraction of the cost compared to others.
Below are outlined some of the most affordable countries for medical education and provide essential tips on how to apply for these programmes.
So, with the National Eligibility cum Entrance Test - Undergraduate (NEET-UG) irregularities tainting every exam conducted by the Centre or related bodies, students are surely looking to pursue medical education abroad. Not to forget the inflated ranks and sky-high cut-offs. Hence, this list actually might come in handy.
Why Germany?
- Free or low tuition fees: Many public universities in Germany offer medical courses either for free or with minimal tuition fees.
- High-quality education: German universities are renowned for their rigorous and high-standard medical education.
- Global recognition: Medical degrees from Germany are recognised worldwide.
Application tips :
- Language proficiency: Most medical programmes in Germany are taught in German. Ensure you have proficiency in the German language and pass the necessary exams (TestDaF or DSH).
- Pre-med course: If your qualifications do not meet the entry requirements, you might need to complete a Studienkolleg, a preparatory course.
- Early application: Apply early through uni-assist, the centralised application service for international students.
Why Poland?
- Moderate tuition fees: Medical schools in Poland charge relatively affordable fees compared to Western Europe and North America.
- English-taught programmes: Many universities offer medical courses in English, making it accessible for international students.
- Quality education: Polish medical universities are known for their high-quality education and practical training.
- Entry exams: Some universities require entrance exams in biology, chemistry, and physics. Prepare thoroughly for these tests.
- Documentation: Ensure you have all necessary documents, including high school diplomas, transcripts, and proof of English proficiency (if applicable).
- Visa requirements: Research and apply for a student visa well in advance to avoid any last-minute issues.
Why the Philippines?
- Affordable education: The Philippines offers medical education at very affordable rates compared to Western countries.
- English instruction: Medical programmes are taught in English, making it an attractive destination for English-speaking students.
- Clinical exposure: The Philippines provides extensive clinical exposure and hands-on training.
Application Tips :
- NMAT: The National Medical Admission Test (NMAT) is required for admission to medical schools in the Philippines. Prepare well in advance.
- Accreditation: Verify that the medical school you choose is accredited by relevant bodies such as the World Health Organization (WHO) or the local health ministry.
- Cultural adaptation: Familiarise yourself with the local culture and customs to ease your transition.
- Low tuition fees: China offers affordable medical education with relatively low tuition fees.
- Scholarships: Various scholarships are available for international students, reducing the financial burden.
- Modern facilities: Chinese medical universities are equipped with modern facilities and technology.
- Language requirements: Some programmes are in Chinese, so you might need to pass the HSK (Chinese Proficiency Test). However, many universities also offer English-taught programmes.
- Application platform: Apply through the official Chinese government scholarship website or directly to the universities.
- Stay informed: Keep updated with any changes in application processes or requirements by regularly checking the universities' official websites.
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There is a correlation between a country's educational system quality and its economic status, with developed nations offering higher quality education.
The U.S., despite ranking high in educational system surveys, falls behind in math and science scores compared to many other countries.
Educational system adequacy varies globally, with some countries struggling due to internal conflicts, economic challenges, or underfunded programs.
While education levels vary from country to country, there is a clear correlation between the quality of a country's educational system and its general economic status and overall well-being. In general, developing nations tend to offer their citizens a higher quality of education than the least developed nations do, and fully developed nations offer the best quality of education of all. Education is clearly a vital contributor to any country's overall health.
According to the Global Partnership for Education , education is considered to be a human right and plays a crucial role in human, social, and economic development . Education promotes gender equality, fosters peace, and increases a person's chances of having more and better life and career opportunities.
"Education is the most powerful weapon which you can use to change the world." — Nelson Mandela
The annual Best Countries Report , conducted by US News and World Report, BAV Group, and the Wharton School of the University of Pennsylvania , reserves an entire section for education. The report surveys thousands of people across 78 countries, then ranks those countries based upon the survey's responses. The education portion of the survey compiles scores from three equally-weighted attributes: a well-developed public education system, would consider attending university there, and provides top-quality education. As of 2023, the top ten countries based on education rankings are:
1 | |
2 | |
3 | |
4 | |
5 | |
6 | |
7 | |
8 | |
9 | |
10 |
Ironically, despite the United States having the best-surveyed education system on the globe, U.S students consistently score lower in math and science than students from many other countries. According to a Business Insider report in 2018, the U.S. ranked 38th in math scores and 24th in science. Discussions about why the United States' education rankings have fallen by international standards over the past three decades frequently point out that government spending on education has failed to keep up with inflation.
It's also worthwhile to note that while the Best Countries study is certainly respectable, other studies use different methodologies or emphasize different criteria, which often leads to different results. For example, the Global Citizens for Human Rights' annual study measures ten levels of education from early childhood enrollment rates to adult literacy. Its final 2020 rankings look a bit different:
Most findings and ranking regarding education worldwide involve adult literacy rates and levels of education completed. However, some studies look at current students and their abilities in different subjects.
One of the most-reviewed studies regarding education around the world involved 470,000 fifteen-year-old students. Each student was administered tests in math, science, and reading similar to the SAT or ACT exams (standardized tests used for college admissions in the U.S.) These exam scores were later compiled to determine each country's average score for each of the three subjects. Based on this study, China received the highest scores , followed by Korea, Finland , Hong Kong , Singapore , Canada , New Zealand , Japan , Australia and the Netherlands .
On the down side, there are many nations whose educational systems are considered inadequate. This could be due to internal conflict, economic problems, or underfunded programs. The United Nations Educational, Scientific, and Cultural Organization's Education for All Global Monitoring Report ranks the following countries as having the world's worst educational systems:
27% | |
31% | |
34% | |
35% | |
37% | |
37% | |
38% | |
41% | |
45% | |
47% |
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| |||||||
---|---|---|---|---|---|---|---|
41% | 2022 | 203 | |||||
35% | 2018 | 202 | |||||
100% | 2016 | 201 | |||||
81% | 2022 | 200 | |||||
88% | 2020 | 198 | |||||
86% | 2015 | 197 | |||||
72% | 2022 | 196 | |||||
54% | 2022 | 195 | |||||
86% | 2022 | 194 | |||||
62% | 2016 | 193 | |||||
90% | 2022 | 192 | 87 | ||||
62% | 2018 | 191 | |||||
0% | 190 | ||||||
83% | 2015 | 189 | |||||
0% | 188 | 77 | |||||
91% | 2015 | 187 | |||||
95% | 2015 | 186 | |||||
89% | 2015 | 185 | |||||
81% | 2021 | 184 | |||||
0% | 183 | ||||||
99% | 2021 | 182 | |||||
0% | 181 | ||||||
95% | 2020 | 180 | |||||
52% | 2017 | 179 | |||||
89% | 2021 | 178 | |||||
92% | 2021 | 177 | |||||
68% | 2022 | 176 | |||||
98% | 2022 | 175 | |||||
95% | 2019 | 174 | 71 | 59 | 70 | 69 | |
97% | 2015 | 173 | |||||
92% | 2021 | 172 | |||||
90% | 2022 | 171 | |||||
98% | 2000 | 170 | |||||
99% | 2005 | 169 | |||||
0% | 168 | ||||||
98% | 2012 | 167 | |||||
100% | 2021 | 166 | 48 | 43 | 40 | 38 | |
98% | 2020 | 165 | |||||
98% | 2022 | 164 | 28 | 28 | 27 | 28 | |
99% | 2021 | 163 | 47 | ||||
45% | 2021 | 162 | |||||
37% | 2020 | 161 | |||||
27% | 2022 | 160 | |||||
63% | 2021 | 159 | |||||
59% | 2022 | 158 | |||||
0% | 157 | ||||||
81% | 2022 | 156 | |||||
31% | 2020 | 155 | |||||
58% | 2022 | 154 | |||||
98% | 2011 | 153 | |||||
62% | 2022 | 152 | |||||
76% | 2022 | 151 | |||||
48% | 2017 | 150 | |||||
82% | 2022 | 149 | |||||
77% | 2022 | 148 | |||||
38% | 2022 | 147 | |||||
37% | 2021 | 146 | |||||
94% | 2021 | 145 | 32 | 35 | 36 | 30 | |
100% | 2021 | 144 | |||||
34% | 2022 | 143 | |||||
77% | 2018 | 142 | |||||
78% | 2020 | 141 | 85 | 78 | |||
100% | 2014 | 140 | |||||
67% | 2021 | 139 | |||||
61% | 2018 | 138 | |||||
0% | 137 | ||||||
58% | 2019 | 136 | |||||
90% | 2019 | 135 | |||||
98% | 2021 | 134 | 51 | 57 | 49 | 43 | |
76% | 2021 | 133 | |||||
89% | 2019 | 132 | 76 | ||||
70% | 2015 | 131 | |||||
47% | 2022 | 130 | |||||
82% | 2022 | 129 | |||||
95% | 2021 | 128 | |||||
98% | 2021 | 127 | 53 | 54 | 58 | 53 | |
84% | 2022 | 126 | 86 | 85 | 78 | 73 | |
49% | 2022 | 125 | |||||
0% | 124 | ||||||
64% | 2015 | 123 | |||||
75% | 2020 | 122 | 84 | 80 | |||
67% | 2019 | 121 | |||||
84% | 2022 | 120 | 83 | 73 | 75 | ||
94% | 2022 | 119 | |||||
91% | 2022 | 118 | |||||
77% | 1999 | 117 | |||||
96% | 2019 | 116 | 75 | 76 | 60 | 56 | |
89% | 2015 | 115 | |||||
90% | 2021 | 114 | 41 | 36 | 33 | 32 | |
77% | 2022 | 113 | 56 | 58 | 57 | 57 | |
90% | 2020 | 112 | 82 | 74 | |||
98% | 2022 | 111 | |||||
0% | 110 | ||||||
89% | 2019 | 109 | 74 | 79 | 76 | 71 | |
100% | 2021 | 108 | |||||
94% | 2021 | 107 | 44 | 48 | 46 | 48 | |
80% | 2020 | 106 | 77 | 69 | |||
89% | 2020 | 105 | |||||
84% | 2022 | 104 | 72 | 75 | 67 | 63 | |
99% | 2019 | 103 | 61 | 66 | 56 | ||
88% | 2022 | 102 | |||||
74% | 2018 | 101 | 34 | 34 | 32 | 34 | |
0% | 100 | ||||||
99% | 2021 | 99 | 43 | 45 | 47 | 40 | |
100% | 2020 | 98 | |||||
0% | 97 | ||||||
95% | 2021 | 96 | 69 | 72 | 69 | 60 | |
94% | 2020 | 95 | |||||
0% | 94 | ||||||
96% | 2020 | 93 | |||||
0% | 92 | ||||||
94% | 2017 | 91 | 33 | 39 | 41 | 37 | |
83% | 2022 | 90 | 70 | 71 | 68 | 68 | |
95% | 2019 | 89 | 39 | 40 | 38 | 39 | |
72% | 2022 | 88 | |||||
100% | 2010 | 87 | |||||
100% | 2019 | 86 | 66 | 61 | 65 | 61 | |
81% | 2001 | 85 | |||||
75% | 2022 | 84 | 37 | 37 | 39 | 42 | |
0% | 83 | ||||||
98% | 2018 | 82 | 59 | 60 | |||
89% | 2021 | 81 | 81 | 74 | |||
99% | 2021 | 80 | |||||
0% | 79 | ||||||
92% | 2021 | 78 | |||||
94% | 2020 | 77 | 68 | 64 | 64 | 59 | |
99% | 2021 | 76 | 46 | 44 | 43 | 33 | |
99% | 2001 | 75 | |||||
96% | 2020 | 74 | 54 | 56 | 51 | 49 | |
81% | 2018 | 73 | 67 | 67 | |||
0% | 72 | ||||||
96% | 2019 | 71 | 52 | 50 | 55 | 52 | |
100% | 2022 | 70 | |||||
70% | 2020 | 69 | |||||
99% | 2019 | 68 | 57 | 68 | 63 | 58 | |
96% | 2020 | 67 | 58 | 52 | 54 | 55 | |
99% | 2022 | 66 | |||||
97% | 1980 | 65 | |||||
100% | 2019 | 64 | |||||
100% | 2022 | 63 | 80 | 84 | 72 | ||
0% | 62 | ||||||
0% | 61 | 79 | 81 | 66 | 67 | ||
98% | 2021 | 60 | |||||
0% | 59 | ||||||
97% | 2022 | 58 | 63 | 70 | 62 | 62 | |
100% | 2019 | 57 | 64 | 53 | 52 | 51 | |
71% | 2021 | 56 | |||||
95% | 2021 | 55 | |||||
94% | 2022 | 54 | 73 | 65 | 73 | 65 | |
96% | 2019 | 53 | 65 | 62 | 59 | 64 | |
99% | 2020 | 52 | |||||
96% | 2020 | 51 | |||||
99% | 2021 | 50 | |||||
99% | 2018 | 49 | |||||
100% | 2018 | 48 | |||||
98% | 2021 | 47 | |||||
99% | 2014 | 46 | |||||
98% | 2020 | 45 | 38 | 32 | 35 | 46 | |
98% | 2021 | 44 | 62 | 63 | 61 | 54 | |
100% | 2020 | 43 | 78 | 82 | 71 | 70 | |
0% | 42 | 22 | 21 | ||||
0% | 41 | 50 | 47 | 45 | 44 | ||
97% | 2022 | 40 | 49 | 51 | 48 | 35 | |
95% | 2020 | 39 | 40 | 41 | 37 | 36 | |
99% | 2018 | 38 | 35 | 33 | 34 | 29 | |
97% | 2019 | 37 | 30 | 31 | 31 | 31 | |
99% | 2018 | 36 | 14 | 13 | 14 | 16 | |
0% | 35 | 16 | 17 | 16 | 13 | ||
99% | 2011 | 34 | 31 | 30 | |||
98% | 2018 | 33 | 29 | 29 | 28 | 26 | |
99% | 2014 | 32 | |||||
0% | 31 | 1 | 1 | 1 | 1 | ||
99% | 2021 | 30 | 36 | 38 | 30 | ||
100% | 2021 | 29 | 60 | 46 | 42 | 45 | |
0% | 28 | 7 | 6 | 6 | 6 | ||
0% | 27 | 15 | 14 | 11 | 14 | ||
100% | 2021 | 26 | 42 | 42 | 44 | 47 | |
100% | 2021 | 25 | 55 | 49 | 50 | 50 | |
97% | 2021 | 24 | 24 | 24 | 25 | 20 | |
100% | 2021 | 23 | 25 | 27 | 26 | 23 | |
100% | 2021 | 22 | 27 | 25 | 23 | 21 | |
92% | 1983 | 21 | 26 | 26 | 24 | 25 | |
99% | 2020 | 20 | 17 | 18 | 17 | 18 | |
0% | 19 | 4 | 4 | 4 | 3 | ||
0% | 18 | ||||||
0% | 17 | 8 | 9 | 8 | 7 | ||
0% | 16 | 5 | 5 | 5 | 5 | ||
0% | 15 | 9 | 8 | 9 | 8 | ||
0% | 14 | ||||||
97% | 2020 | 13 | 23 | 23 | 22 | 24 | |
0% | 12 | 2 | 2 | 2 | 2 | ||
97% | 2020 | 11 | 20 | 22 | 21 | 19 | |
0% | 10 | 21 | 20 | 20 | |||
0% | 9 | 13 | 12 | 13 | 12 | ||
0% | 8 | 12 | 15 | 15 | 15 | ||
0% | 7 | 3 | 3 | 3 | 4 | ||
0% | 6 | 6 | 7 | 7 | 11 | ||
100% | 2001 | 5 | 45 | 55 | 53 | 41 | |
0% | 4 | 18 | 16 | 18 | |||
0% | 3 | 11 | 10 | 10 | 9 | ||
0% | 2 | 10 | 11 | 12 | 10 | ||
0% | 1 | 19 | 19 | 19 | 22 | ||
97% | 2006 | ||||||
100% | 2000 | ||||||
99% | 2021 | ||||||
100% | 2015 | ||||||
97% | 1980 | ||||||
73.12% |
Which country ranks last in education, frequently asked questions.
BMC Emergency Medicine volume 24 , Article number: 113 ( 2024 ) Cite this article
Metrics details
The purpose of this study was to investigate the preferred modes of transportation to the hospital among patients with acute stroke and acute myocardial infarction (AMI), as well as to identify the factors that influence the utilization of ambulances.
We conducted a cross-sectional study, including patients who were diagnosed with acute stroke and AMI, at the people’s hospital of Zhongjiang, from September 30th, 2022 to August 30th, 2023. All patients were divided into emergency medical service (EMS)-activation group and self-transportation group. Chi-square and t-tests were utilized to discern differences between groups at baseline. To screen relevant variables, we employed the Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis using R package glmnet. Subsequently, we performed a logistic regression analysis to identify predictors of EMS activation according the results of LASSO regression.
we collected 929 valid questionnaires. 26.16% of the patients required the services of EMS. 90.9% of individuals have not received any formal first aid education. 42.1% of them reported that they had no understanding of cardiovascular and cerebrovascular diseases. Diagnosed as AMI (OR 0.22, 95%CI 0.06 to 0.88) or acute cerebral infarction (OR 0.26, 0.10 to 0.68), the distance between the patient and the nearest 120 network hospital when the patient had these symptoms (OR 0.97, 0.94 to 0.99), the patient’s son or daughter was there when the patient was symptomatic (OR 0.58, 0.37 to 0.94), the patient (OR 0.19, 0.05 to 0.72) and the patient’s partner (wife or husband) (OR 0.36, 0.16 to 0.85) had decided that the patient needed further medical help, Among patients who did not seek immediate help after symptom onset, thinking that the symptoms will disappear spontaneously (OR 0.34, 0.13 to 0.92) or not wanting to disturb others (OR 0.06, 0.01 to 0.66) or believing that they are not important symptoms (OR 0.15, 0.05 to 0.42) were factors independently associated with less ambulance use. Age (OR 1.02, 1.00 to 1.04), Stroke patients have experienced symptoms of disturbance of consciousness or convulsions (OR 2.99, 1.72 to 5.2) were independent factors associated with increased ambulance use.
There is still ambulance underutilization among patients with acute stroke and AMI in county territory of China. Moreover, it is needed to raise the level of first aid education and awareness about EMS. Additionally, private clinic doctors and the public should gain adequate understanding of the severity of acute stroke and AMI, as well as their common symptoms, the crucial importance of prompt medical intervention. Finally, we propose that all township hospitals should be integrated into the 120 emergency networks and equipped with emergency first aid capabilities, pre-hospital care, and transportation abilities.
Peer Review reports
Acute stroke and acute myocardial infarction (AMI) pose a significant threat to the health of the Chinese population [ 1 , 2 ]. According to the 2019 Global Burden of Disease study, China experienced 3.94 million new cases of stroke in 2019, with 28.76 million existing cases. Of these cases, 2.19 million resulted in death, with 82.6% being ischemic strokes [ 2 ]. Stroke exhibits high mortality and disability rates, serving as a major cause of death and disability among Chinese adults [ 2 ]. For acute ischemic stroke, prompt interventions such as intravenous thrombolysis and endovascular treatment administered within the critical time window can effectively dissolve blood clots and restore blood flow [ 3 ]. This timely approach significantly improves clinical outcomes, reduces mortality rates, and minimizes disability [ 3 ]. Similarly, AMI has a high incidence and mortality rate worldwide [ 4 ].In China, there is a high incidence rate of coronary artery disease(CAD), and the mortality rate of AMI has shown a rapid and continuous upward trend from 2012 to 2020. Specifically, the AMI mortality rate increased from 68.62 to 135.88 per 100,000 rural population, and from 93.17 to 126.91 per 100,000 urban population annually [ 5 ]. Early reperfusion therapy, including intravenous thrombolysis and percutaneous coronary intervention (PCI), is crucial for managing AMI [ 1 , 4 ].
Emergency Medical Service (EMS) play a crucial role in swiftly transporting patients and providing initial treatment, and early activation of EMS is vital for promptly diagnosing and treating acute stroke and AMI patients [ 6 ]. For patients experiencing acute stroke and AMI, the timely activation of EMS is paramount. The direct correlation between prompt EMS activation and improved clinical outcomes is crucial in ensuring optimal patient care and recovery [ 6 , 7 ]. However, in China, especially in rural or county-level areas, the utilization of ambulances for acute ischemic stroke and AMI patients remains low [ 6 ]. Some studies have explored factors influencing the non-use of ambulances by patients with acute coronary syndrome [ 6 , 8 , 9 , 10 , 11 ] and the pre-hospital delay in stroke patients [ 7 ]. However, data regarding reasons for the delayed initiation of EMS in acute stroke and AMI patients in county-level areas are lacking.
This study aims to analyze the barriers preventing the initiation of EMSS in patients with acute stroke and AMI, which could contribute to targeted solutions and improved time management for these conditions. This would subsequently enhance patient outcomes and provide greater benefits to affected individuals. Moreover, the research findings can serve as valuable references for county-level areas in China, benefiting a diverse populace and potentially contributing to socioeconomic improvements.
We conducted a prospective, single-center, cross-sectional study, including the patients who were diagnosed with acute stroke and AMI, at the people’s hospital of Zhongjiang, a tertiary hospital in Zhongjiang County of Sichuan Province, from September 30, 2022, to August 30, 2023. All the patients were onseted in the territory of Zhongjiang County. Some came to our hospital by call the EMS (EMS-activation group), while some came without activating the EMS (self-transportation group).
Patients were included if they were (1) 14 years and older, (2) with acute stroke and AMI symptoms occurred within 3 days, (3) presenting to the Emergency Department, (4) definitively diagnosed as acute stroke and AMI.
Patients were excluded if they were (1) unwilling to participate in the questionnaire survey, (2) patients with acute stroke or AMI who had started treatment outside of Zhongjiang County and were subsequently transferred to our hospital. (3) the patients were unable to respond to the questionnaires, and no one knew the actual situation.
Zhongjiang County is located in the central Sichuan hilly region, in the northwest of the Sichuan Basin. The county covers an area of 2,200 square kilometers, including 26 towns and 4 townships, totally 522 villages (communities). According to the 2021 census data, Zhongjiang County has a registered population of 1.363 million and a permanent population of 948,000, with an urbanization rate of 42.9% for the permanent population. There are seven hospitals affiliated with the 120 emergency medical network in Zhongjiang County. Figure 1 provides a map of Zhongjiang County and its neighboring areas, highlighting the locations of these 120 network hospitals.
The map of Zhongjiang County and its neighboring areas, and the locations of these 120 network hospitals. The blue dotted line demarcates the boundaries of Zhongjiang County
The people’s hospital of Zhongjiang serves as a significant tertiary medical hub in Zhongjiang County, Sichuan Province. It provides round-the-clock services, seven days a week, for intravenous thrombolysis and endovascular intervention for cerebral infarction, as well as PCI-mediated reperfusion therapy for AMI.
The questionnaire comprehensively covers various aspects related to patients’ experiences with acute stroke and AMI, from basic demographic details to their level of disease awareness, healthcare-seeking behavior, and potential causes of delayed EMS activation. Besides, it also explores their hypothetical actions and reasons if a similar situation were to occur again. The specific contents of the questionnaire are detailed in the supplementary document.
The design of the questionnaire initially referenced questionnaires from other studies [ 6 , 12 ] and was adjusted according to the actual situation. Following this, a pilot testing phase was conducted to evaluate its effectiveness. Based on the feedback of the pilot test and expert reviews, further revisions were made repeatedly to the questionnaire. Finally, the revised questionnaire was deemed ready for larger-scale administration.
Patients who experienced acute stroke and AMI were initially screened upon arrival at the Emergency Department. Subsequently, they or their family member were invited by a trained investigator within 2 days to participate in the study and complete the questionnaire. The data collection was conducted on the phone using a WeChat mini-program, according to the standard data collection protocol developed by the research team.
If the patients were able to express themselves, the patients or their family members would complete the questionnaire based on the patient’s statements. If the patients were unable to respond to the questionnaires due to unconsciousness, aphasia, or being intubated, then their family members would complete the questionnaire based on the actual situation. If the patients were in the Intensive Care Unit or had passed away with no family members present in the hospital, the investigator would complete the questionnaire through a telephone interview. If the family members did not have a phone or were unfamiliar with the process, the investigator would complete the questionnaire or guide them through the process.
The questionnaire items that are most likely to lead to bias are as follows: (1) When inquiring about the symptoms of cardiovascular and cerebrovascular diseases before the onset of the illness, respondents often choose current symptoms. The investigator must clarify that the intent is to gauge understanding of these diseases before onset, not current manifestations. (2) During the inquiry about the distances patients were away from those three places, respondents frequently offer rough estimates in kilometers, which may result in significant errors. For those who are unsure of the distance, the investigator uses navigation software to measure the exact distance. (3) When inquiring about hypothetical actions and reasons in the event of a similar situation recurring, respondents often consider some factors and make choices that may not reflect their actual intentions. Based on their responses during the interview, the investigator will offer guidance to mitigate potential errors.
Categorical variables are presented as frequency (percentage) and were compared using the Chi-square test or Fisher’s exact test. Normally distributed continuous variables are presented as mean ± SD and were compared with the t-test. Non-normally distributed continuous variables are presented as median (95% confidence interval [CI]) and were compared with the Mann–Whitney test if independent or the Wilcoxon test in case of dependent variables. P value < 0.05 was considered statistically signifcant. All data were anonymized and analyzed with SPSS (version 20.0) and R (version 4.2.3).
In our study, Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis was performed to screen the most relevant variables using the glmnet package in R. This popular method avoids overfitting by incorporating the best performance parameters, resulting in a simpler and more easily interpreted model. LASSO regression was chosen for this analysis due to its ability to efficiently perform variable selection and handle multicollinearity. By penalizing the sum of absolute coefficients, LASSO automatically shrinks some coefficients to zero, selecting only the most relevant variables and reducing the influence of less correlated predictors. Furthermore, LASSO’s computational efficiency allows it to handle large datasets effectively. In comparison to other regression methods, LASSO offers a unique combination of variable selection, regularization, and prediction accuracy, making it a robust choice for this analysis.
Subsequently, we conducted a logistic regression analysis to further examine the predictors of EMS activation according the results of LASSO regression. In selecting the final logistic regression model, we incorporated variables that were selected by the LASSO regression procedure and those that demonstrated statistical significance. We comprehensively evaluated the model’s goodness of fit and predictive performance using Nagelkerke’s R² value, the p value and the prediction accuracy across different groups. The Harrell’s C-index was used to quantify and validate the concordance performance of the model. To obtain a relatively corrected estimate of the C-index, the model was subjected to bootstrapping validation with 1,000 bootstrap resamples. Through the multivariable logistic regression analysis, we obtained some results that more accurately depicts the relationship between the predictors and the EMS activation outcome.
During the study period, 1082 patients with acute stroke and AMI were admitted to our hospital. Among them, 582 patients had acute cerebral infarction, 354 patients had acute cerebral hemorrhage, 48 patients had acute spontaneous subarachnoid hemorrhage, and 98 patients had AMI. However, a total of 153 patients were excluded from the study for various reasons, including unwillingness to participate in the questionnaire survey, failure of the investigator to complete the survey, invalid questionnaires, and patients with acute stroke or AMI who had started treatment outside of Zhongjiang County and were subsequently transferred to our hospital, as they met the exclusion criteria. The final result was that we collected 929 valid questionnaires. Among them, 243 (26.16%) called for EMS (EMS-activation group), while the remaining did not call for EMS (self-transportation group).
Table 1 lists social demographics, cardiovascular history, risk factors in the overall population and comparison between EMS-activation group and self-transportation group. No statistical differences were observed in age, gender, educational level, marriage status, risk factors and previous cardiovascular or cerebrovascular diseases. Only the answers regarding whether they have ever received first aid education showed statistical differences between the two groups. The self-transportation group was more likely to report not knowing the 120 emergency phone number (11.4% vs. 6.2% P = 0.02), whereas the EMS-activation group was more likely to have studied first aid through media or the Internet (9.5% vs. 5.2% P = 0.02).
Table 2 lists understandings of cardiovascular and cerebrovascular diseases in the overall population and comparison between EMS-activation group and self-transportation group. The EMS-activation group was more likely to believe that cardiovascular and cerebrovascular diseases have symptoms such as disorders of consciousness or convulsions (11.1% vs. 6.7% p = 0.03) and chest pressure (7.8% vs. 3.8% p = 0.02). In addition, it is worth noting that 42.1% of them reported that they had no understanding of cardiovascular and cerebrovascular diseases.
Table 3 lists symptom characteristics when the symptoms occurred in the overall population and comparison between the two groups. The most common symptom in patients with acute stroke was that one side of the limb is weak or numb or clumsy, which occurs in 58.0% of cases. Meanwhile, chest pain was the most common symptom occurring in 73.3% of patients with AMI. One side of the limb is weak or numb or clumsy (50.7% vs. 60.7%, p < 0.01) was associated with decreased use of ambulance. At the same time, chest pain(78.6% vs. 50.0%, p = 0.03) was associated with increased use of ambulance.
Table 4 lists informations regarding the situation when the symptoms occurred in the overall population and comparison between the two groups. The median time of the onset to hospital arrival in EMS-activation group was 2.5 h, whereas in the self-transportation group, the median time was 5.0 h, with p < 0.001. Additionally, in EMS-activation group, the median time of the onset to EMS calling was 2.00 h (Interquartile Range [IQR]: 0.67–5.00 h) and the median time of EMS calling to hospital arrival was 0.81 h (IQR: 0.48–1.31 h).
Patients diagnosed with acute cerebral hemorrhage (43.6% vs. 26.7%) and acute spontaneous subarachnoid hemorrhage (5.8% vs. 2.2%) exhibited significantly higher utilization of ambulances compared to those diagnosed with acute cerebral infarction (44.0% vs. 60.9%) and AMI (6.6% vs. 10.2%), with a statistically significant difference ( p < 0.001).
The distribution of symptom onset times among patients also had statistically significant implications for their decision to call an ambulance ( p < 0.01). There were higher numbers of ambulance calls from 5 pm to 8 pm (22.6% vs. 14.9%), 9 pm to midnight (7.8% vs. 7.3%), 1 am to 4 am (8.6% vs. 7.3%), and 9 am to 12 pm (28.8% vs. 25.1%). Conversely, lower numbers of ambulance calls were observed between 5 am and 8 am (18.5% vs. 27.0%), 1 pm and 4 pm (13.6% vs. 18.5%).
When the patient had these symptoms, the median distance to the nearest township hospital was 2 km for the EMS-activation group and 3 km for the self-transportation group ( p = 0.03). The median distance between the patient and the nearest 120 network hospital was 10 km for the EMS-activation group and 14 km for the self-transportation group ( p < 0.001). Meanwhile, the median distance between the patient and the people’s hospital of Zhongjiang was 15 km for the EMS-activation group and 20 km for the self-transportation group ( p < 0.001).
When asked where was the patient when these symptoms occur, patients who were in a public place (11.5% vs. 7.0%) had a higher utilization of ambulance services compared to those who were at home (75.3% vs. 82.7%) ( p = 0.03).
Before making an emergency call or going to the hospital, the patient’s relatives (77.4% vs. 71.6%), friend (6.6% vs. 3.6%), doctors in a private practice (2.1% vs. 1.0%), and other individual (6.6% vs. 3.3%) who realized that this was a serious problem were associated with increased use of ambulance compared to the patient (6.2% vs. 16.6%), and no one (1.2% vs. 3.8%) ( p < 0.001). While, when doctor from a nearby township hospital (10.3% vs. 9.8%), other doctor (1.6% vs. 1.5%), the patient’s friends (3.7% vs. 1.2%), colleagues (1.2% vs. 0.9%), and other individual (9.5% vs. 3.6%) who decided that the patient needed further medical help, there were higher numbers of ambulance calls than the patient (2.1% vs. 10.8%), the patient’s partner (18.1% vs. 18.5%), and private clinic (0.4% vs. 1.3%) ( p < 0.001).
When asked what caused them not to seek help immediately after symptoms appeared, the self-transportation group was more likely to believe that the symptoms would disappear spontaneously (18.4% vs. 7.4%), they were not important symptoms (17.8% vs. 6.6%), didn’t want to disturb others (3.4% vs. 0.4%) compare to the EMS-activation group. While, the EMS-activation group was even more likely to think that it wasn’t a heart or brain problem (2.1% vs. 1.6%) ( p < 0.001).
Table 5 lists Informations about how patients arrived at the hospital, their reasons for this choice, and their actions if such a situation were to occur again among the 686 patients in the self-transportation group. The results of the survey show that the majority of patients arrive at the hospital by private transportation, either driven by a relative or friend (56.6%) or by the patient themselves (24.2%). Meanwhile, a minority chose to charter a private vehicle (11.5%).
When asked why they didn’t call 120 EMS, the most common reasons were that patients believed a private transport would be faster (38.9%), they didn’t think the health issue was severe enough to require an ambulance (24.9%), some patients didn’t consider it (13.4%), and some were already in a private vehicle (9.3%).
When asked if they would call 120 or use private transportation to return to the hospital in the event that the time were to go back and the patients became ill again or displayed the same symptoms, the results were that 45.3% would call 120, while 54.4% would still choose private transportation to go to the hospital. The main reason for preferring private transportation was that it was faster (73.2%), more convenient (26.8%), or patients thought that the disease wasn’t serious (12.8%). Some also believed that driving themselves was more economical (2.9%). For those who would call 120 again, the top reasons were that the medical staff in the ambulance was more professional (29.1%) and that ambulance was faster (25.6%). Other reasons included thinking the disease was serious (21.7%), believing the ambulance service was more convenient (8.9%).
Figure 2 demonstrates the results of LASSO regression analysis, which was performed to screen variates to avoid overfitting and to generate a simpler interpreted model. Finally, 32 prognostic variates were selected, including diagnosis, the distance between the patient and the nearest 120 network hospital, the distance between the patient and the people’s hospital of Zhongjiang, the question of whether you have ever received first aid education (I didn’t even know the 120 emergency phone number, I had studied it in my compulsory education courses, I had studied in the media and on the Internet), the understanding of the symptoms of cardiovascular and cerebrovascular diseases prior to this illness (chest pressure, headache, headache associated with nausea and vomiting, one side of the face numbness or askew of the mouth, both eyes are fixed and can not rotate, disorders of consciousness or convulsions, having no understanding of cardiovascular and cerebrovascular diseases), the symptoms experienced by the patient with AMI (chest pressure, sweating, nausea and vomiting), grades of chest pain, the symptoms experienced by the patient with acute stroke(headache, headache associated with nausea and vomiting, dizziness, one side of the limb is weak or numb or clumsy, loss or blurred vision on either one side or both eyes, optic rotation or balance disorder, disorders of consciousness or convulsions), the place where the patient was when these symptoms occur, the person who was there when the patient was symptomatic(no one, the patient’s son or daughter), the person who realized that the problem was serious before making an emergency call or going to the hospital, the place where the patient sought medical attention in the first instance, the person who had decided that the patient needed further medical help, the reasons that caused the patient didn’t seek help immediately after symptoms.
The least absolute shrinkage and selection operator (LASSO) regression analysis. Prognosis-related variates selection in the LASSO regression ( A ). The selection of LASSO regression truncation value ( B ). The dotted line a represents the lambda corresponding to the lowest error mean. The dotted line b represents the maximum lambda corresponding to the error mean within one standard deviation of the minimum
Table 6 lists the final result of multivariable logistic regression analysis. It showed that diagnosed as AMI (OR 0.22, 95%CI 0.06 to 0.88) or acute cerebral infarction (OR 0.26, 0.10 to 0.68), the distance between the patient and the nearest 120 network hospital when the patient had these symptoms (OR 0.97, 0.94 to 0.99), the patient believed that the symptoms of cardiovascular and cerebrovascular diseases included headache accompanied by nausea and vomiting(OR 0.35, 0.18 to 0.69), one side of the face numbness or askew of the mouth (OR 0.51, 0.28 to 0.91) before the onset of this illness, the patient’s son or daughter was there when the patient was symptomatic (OR 0.58, 0.37 to 0.94), the patient (OR 0.19, 0.05 to 0.72) and the patient’s partner (wife or husband) (OR 0.36, 0.16 to 0.85) had decided that the patient needed further medical help, Among patients who did not seek immediate help after symptom onset, thinking that the symptoms will disappear spontaneously (OR 0.34, 0.13 to 0.92) or not wanting to disturb others (OR 0.06, 0.01 to 0.66) or believing that they are not important symptoms (OR 0.15, 0.05 to 0.42) were factors independently associated with less ambulance use. Age (OR 1.02, 1.00 to 1.04), and stroke patients have experienced symptoms of disturbance of consciousness or convulsions (OR 2.99, 1.72 to 5.2) were independent factors associated with increased ambulance use. The model is statistically significant with a p-value less than 0.001, and its Nagelkerke’s R 2 is 0.34. Meanwhile, the model’s overall comprehensive prediction accuracy is 80.0% (for the self-transportation group, the prediction accuracy is 93.9%, while, for the EMS-activation group is 40.7%). The C-index for the model was 0.812 (95% CI: 0.810–0.814), and upon bootstrapping validation, it was validated to be 0.744, indicating moderate accuracy of the model.
There is still ambulance underusage among patients with acute stroke and AMI in county territory of China. In our study, 26.16% of the patients required the services of EMS, which is comparable to the findings of a study conducted seven years ago by Qilu Hospital of Shandong University, where 21.6% of patients with acute coronary syndrome (ACS) were transported to the hospital via ambulance [ 6 ]. However, in Northern Italy, 65.2% of patients with ST-segment elevation acute coronary syndromes called for EMS [ 12 ]. Meanwhile, in Ireland, the percentage of ACS patients using ambulances was 27% [ 8 ] or 40.1% [ 10 ]. Therefore, the proportion of our patients with acute stroke and AMI who call the 120 still requires enhancement.
It is worth noting that 80.9% of individuals only know that they can call the 120 when they need first aid, and they have not received any formal first aid education. In addition, 10% of individuals are unaware of the 120 emergency phone number altogether. This also shows that the level of first aid education in China remains low [ 13 ]. Furthermore, the EMS-activation group tended to have a higher likelihood of having studied first aid through media or the Internet. In addition, 40.9% of overall patients didn’t seek help immediately after symptoms appeared. When asked what caused this, 15.5% of overall patients believed that the symptoms would disappear spontaneously, while 14.9% thought that they were not important symptoms. These revelations highlight the importance of not only promoting awareness of EMS but also enhancing public education on common health issues related to cardiovascular and cerebrovascular diseases. Such efforts would contribute significantly to improving the level of emergency first aid for acute stroke and heart attacks.
To enhance first aid education, there are multifaceted approaches encompassing mandatory school programs, community workshops, mass media campaigns, and partnerships with non-governmental organizations and private sectors to ensure widespread knowledge and skills.
Moreover, due to the widespread ownership of cars currently, many individuals opt to drive themselves, relatives, or friends to the hospital. The most common reasons for not calling the EMS were patients’ belief that private transportation would be swifter (38.9%) and their assessment that the health issue was not severe enough to necessitate an ambulance (24.9%). In addition, among those in the self-transportation group, 54.4% would still opt for private transportation if the situation arose again, citing the primary reasons for believing that the private vehicle was faster (73.2%), more convenient (26.8%), and the disease wasn’t serious (12.8%). On the other hand, those who would call the 120 in similar circumstances primarily cite the ambulance’s professional medical staff (29.1%), its speed (25.6%), and the seriousness of the illness (21.7%) as reasons for their choice. Correspondently, in Italy, Among those who did not activate EMS, 45.5% believed their symptoms were unrelated to a significant health issue, and 34.7% thought the private vehicle would be faster than an ambulance [ 12 ]. In summary, our stroke/chest pain center must diligently strive to enhance public awareness regarding acute stroke and heart attacks, and to popularize first aid education.
On the other hand, when patients presented these symptoms, the EMS-activation group had a median distance of 2 km to the nearest township hospital, 12 km to the nearest 120 network hospital, and 20 km to the people’s hospital of Zhongjiang. Notably, the EMS-activation group tended to have shorter distances to these three locations compared to the self-transportation group. Based on this, we propose that all township hospitals should be integrated into the 120 emergency networks and equipped with emergency first aid capabilities, as well as pre-hospital care and transportation abilities. Furthermore, the implementation strategies for this integration involve Securing government backing, obtaining administrative directives, establishing a coordination mechanism, standardizing protocols, upgrading infrastructure and equipment, training staff, and establishing communication links, among other steps. This integration is expected to increase efficiency in emergency response, improve resource utilization, enhance patient experience, and strengthen public trust in the healthcare system, among other benefits.
Patients were more inclined to opt for an ambulance when symptoms occurred at night, this is similar to another study on ACS [ 6 ]. When symptoms occurred, 80.7% of patients were at home, exhibiting a lower utilization of EMS compared to those who were in public places. Additionally, 45.1% of them were accompanied by their partner, and 28.1% were with their son or daughter. Notably, those accompanied by family members also tended to have a lower utilization of EMS. This might be caused by the perception that it wasn’t a serious problem. Prior research has demonstrated that patients tend to call an ambulance when they perceive their symptoms as being sufficiently serious [ 6 , 11 ]. Furthermore, in our study, before making an emergency call or going to the hospital, the patient and no one who realized that this was a serious problem were associated with decreased use of ambulance compared to when the patient’s relatives, friends, or doctors in private practice were involved. While, when the patient, the patient’s partner, and the private clinic decided that the patient needed further medical help, there were lower numbers of ambulance calls. These further indicate that patients, their families, and private clinic doctors lack adequate understanding of the potentially grave consequences of acute stroke and AMI, as well as the critical importance of prompt medical intervention.
Finally, in discussing our findings, we must address the potential issue of selection bias and its impact on the generalizability of our results. Our samples originated from a central hospital in Zhongjiang County, and neighboring hospitals may have also included minor patients. Selection bias may also arise due to voluntary participation, a unique patient population, and investigator variations. Given that there are over 2,000 county units in China, the specific socioeconomic, demographic, and healthcare context of Zhongjiang County may limit the generalizability of our findings. However, we believe that many of our findings can still provide valuable insights for many other regions with similar characteristics. We recommend improved training for investigators and enhanced research methods to mitigate bias and improve the reliability and generalizability of future studies.
In summary, Ambulance underutilization persists among patients with acute stroke and AMI in county territory of China, coupled with low levels of first aid education. Our findings underscore that it is needed to raise the level of first aid education and awareness about EMS. Moreover, it is crucial for private clinic doctors and the public to recognize typical symptoms and potential dangers of acute stroke and AMI, as well as the significance of prompt EMS services and timely treatment at chest pain/stroke centers. Finally, we propose that all township hospitals should be integrated into the 120 emergency networks and equipped with emergency first aid capabilities, pre-hospital care, and transportation abilities. These efforts would contribute significantly to improving the level of emergency first aid for acute stroke and heart attacks.
The datasets that were used and/or analyzed during the current study are available from the corresponding author upon reasonable request.
Emergency Medical Service
Acute Myocardial Infarction
Least Absolute Shrinkage and Selection Operator
Acute Coronary Syndrome
Percutaneous Coronary Intervention
Interquartile Range
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Colleagues including Kai Long, Tao Xu, Bin Liu, Bin Tang, Jianwei Xu, Shan Chen, Huan Yang, Xueqin Wang, and Xiaoju Wang, as well as intern doctors Guo Hu, Muxiaolong Li, Miao Zhou, Wen He, and Liang Wang, partially contributed to the questionnaire survey or enrollment process. Thanks to them and to all the other individuals who have assisted in this study.
This study was supported by Deyang Science and Technology Program (2022SCZ103).
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Department of Emergency Medicine, People’s hospital of Zhongjiang, Deyang, Sichuan, China
Chengcheng He, Meimei Tang, Xiaohua Ai, Mingxiang Tang, Cheng Tang, Li Li, Wenjin Huang, Xin You, Dewen Zhou, Jiming Zhou, Yan Shi & Min Luo
Department of Neurology, People’s hospital of Zhongjiang, Deyang, Sichuan, China
Yingchun Zhang
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He Chengcheng, Ai Xiaohua, Tang Mingxiang, and Tang Meimei conceived the study and supervised the conduct of the study. He Chengcheng designed the trial and obtained research funding. He Chengcheng, Tang Cheng, Li Li, and Huang Wenjin undertook the recruitment of participating patients. He Chengcheng, Zhang Yingchun, Tang Cheng, Li Li, Huang Wenjin, You Xin, Zhou Dewen, Zhou Jiming, Shi Yan, and Luo Min conducted data collection. Ai Xiaohua chaired the data oversight committee, while He Chengcheng, Tang Meimei, and Tang Mingxiang managed the data and conducted quality control. He Chengcheng and Zhang Yingchun analyzed the data and drafted the manuscript and all authors contributed substantially to its revision.
Correspondence to Chengcheng He or Xiaohua Ai .
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The ethical approval, with approval reference number JLS-2022-034, was obtained from the Ethics Committee of the People’s Hospital of Zhongjiang before initiation of the study. Prior to administering any questionnaire survey, informed consent was obtained from all patients capable of expressing themselves, or from their family members if patients were unable to do so. The Ethics Committee of the People’s Hospital of Zhongjiang is affiliated with the People’s Hospital of Zhongjiang.
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He, C., Zhang, Y., Tang, M. et al. Analysis of barriers associated with emergency medical service activation in patients with acute stroke and acute myocardial infarction from Zhongjiang County of Sichuan Province in China. BMC Emerg Med 24 , 113 (2024). https://doi.org/10.1186/s12873-024-01035-5
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DOI : https://doi.org/10.1186/s12873-024-01035-5
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While Chinese institutions are increasingly participating in the international R&D network of multinational pharmaceutical companies, and clinical research programs in China are more synchronized with the world, the particular needs of Chinese patients are more visible and better represented today than ever before, experts said.
Wang Bin, general manager of Boehringer Ingelheim Biopharma China, said that one obvious change in the domestic biopharma industry over the past decade is that the R&D focus shifted toward disease categories that afflict Chinese more often.
The change has become evident in the number of company clients included in the contract development manufacturing organization model, which allows research-oriented companies to focus on R&D while outsourcing drug development and manufacturing to Boehringer Ingelheim, he said.
"A decade ago, the most common practice in the domestic biopharma field was to produce generic drugs, and therefore most drugs were for the treatment of diseases with a high incidence in the West-but not necessarily high in China," Wang said.
"However, drug development tailor-made for China and Asia is a growing trend. More drug R&D programs are focused on lung cancer, intestinal cancer and some other diseases that severely affect Chinese people's health," he said.
At Draeger Medical Equipment, based in Germany, there are around 100 Chinese scientists and engineers working at its China R&D center, accounting for 10 percent of the company's global R&D effort, said Gabor Polivka, CEO of the company's division in China.
"Chinese researchers played a big role in incorporating 4G technologies and network connections in our medical devices for doctors to monitor the condition of patients, the application of which was remarkable when treating COVID-19 cases in quarantine wards," Polivka said.
Another example was masks, he said. When the company started producing masks in China last year, the China team made changes in the design to make them better fit Asian faces.
"Today, masks made in China are sold not only in China but also in some other regions of Asia," Polivka said.
For Swiss pharmaceutical company Novartis, the new arrangement ensures that China teams provide input to its global development programs much earlier.
"We now consider feedback from our local China team as well as Chinese regulators. At the same time, we consider feedback from other major global regulators in designing our phase 3 studies," said Vas Narasimhan, Novartis CEO.
Johan Kahlstroem, head of the cardiovascular, renal and metabolism business unit at Novartis Pharma (China), said 100 percent of its clinical trials in relevant disease areas in China take place simultaneously with global trials today.
"The inclusion of Chinese patients directly in our trials does not mean only a minimized gap between the launch of a new drug in the West and in China. Starting trials earlier also means that we can use the insights from a clinical program as early as possible and implement them in others," Kahlstroem said.
Early insights may also give clues to R&D teams on the treatment patterns of a potential new therapy and how it actually interacts with the standard therapy in China, he said. "Early insights help us really drive clinical preparedness for using a drug," he said.
Edwards Life sciences, which has been introducing heart valve and critical care products to China over the past two decades, said that it shares the vision of having Chinese clinical teams involved in R&D on its therapies.
Michael Mussallem, chairman and CEO of Edwards Life sciences, said the company is encouraged that research teams at Chinese hospitals have been increasing their capabilities, and the company is also improving its in-country clinical resources.
"For example, we conducted field research with Chinese physicians on a key pipeline technology for surgical treatment of heart valve disease so that their voices can be better heard in this important therapeutic area," he said.
One recent example was the recent publication of the first 200 commercial case results of the company's transcatheter aortic valve system Sapien 3 performed by Chinese doctors in real-world settings, which demonstrated exciting results, said Mussallem. Transcatheter procedures are minimally invasive surgeries that can be used to replace heart valves.
"We look forward to continuing our work with hospitals and clinicians around China to address the unmet needs in the treatment of aortic, mitral and tricuspid valve disease, and to generate early data and evidence that'll be relevant globally," he said.
To have Chinese patients' needs better represented, United States-based pharmaceutical company Bristol Myers Squibb recently made a change in the reporting procedures of its China R&D departments.
Instead of reporting to their respective global departments, they now report to the company's R&D head in China, who then reports to the company's global executive vice-president in charge of drug development.
The company has over 30 clinical trials ongoing in China of immuno-oncology treatment, which uses a person's immune system to fight cancer. They cover cancers of the lung, liver, stomach and esophagus, which are more common in China.
In the field of immunology, the company said it has eight clinical trials in different phases, covering illnesses such as Crohn's disease-an inflammation of the bowel-the skin disease psoriasis and lupus nephritis, a kidney condition brought on by the autoimmune disease lupus. These are illnesses for which patients have long awaited new therapies.
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Objectives: The purpose of this study was to investigate the preferred modes of transportation to the hospital among patients with acute stroke and acute myocardial infarction (AMI), as well as to identify the factors that influence the utilization of ambulances.
Methods: We conducted a cross-sectional study, including patients who were diagnosed with acute stroke and AMI, at the people's hospital of Zhongjiang, from September 30th, 2022 to August 30th, 2023. All patients were divided into emergency medical service (EMS)-activation group and self-transportation group. Chi-square and t-tests were utilized to discern differences between groups at baseline. To screen relevant variables, we employed the Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis using R package glmnet. Subsequently, we performed a logistic regression analysis to identify predictors of EMS activation according the results of LASSO regression.
Results: we collected 929 valid questionnaires. 26.16% of the patients required the services of EMS. 90.9% of individuals have not received any formal first aid education. 42.1% of them reported that they had no understanding of cardiovascular and cerebrovascular diseases. Diagnosed as AMI (OR 0.22, 95%CI 0.06 to 0.88) or acute cerebral infarction (OR 0.26, 0.10 to 0.68), the distance between the patient and the nearest 120 network hospital when the patient had these symptoms (OR 0.97, 0.94 to 0.99), the patient's son or daughter was there when the patient was symptomatic (OR 0.58, 0.37 to 0.94), the patient (OR 0.19, 0.05 to 0.72) and the patient's partner (wife or husband) (OR 0.36, 0.16 to 0.85) had decided that the patient needed further medical help, Among patients who did not seek immediate help after symptom onset, thinking that the symptoms will disappear spontaneously (OR 0.34, 0.13 to 0.92) or not wanting to disturb others (OR 0.06, 0.01 to 0.66) or believing that they are not important symptoms (OR 0.15, 0.05 to 0.42) were factors independently associated with less ambulance use. Age (OR 1.02, 1.00 to 1.04), Stroke patients have experienced symptoms of disturbance of consciousness or convulsions (OR 2.99, 1.72 to 5.2) were independent factors associated with increased ambulance use.
Conclusion: There is still ambulance underutilization among patients with acute stroke and AMI in county territory of China. Moreover, it is needed to raise the level of first aid education and awareness about EMS. Additionally, private clinic doctors and the public should gain adequate understanding of the severity of acute stroke and AMI, as well as their common symptoms, the crucial importance of prompt medical intervention. Finally, we propose that all township hospitals should be integrated into the 120 emergency networks and equipped with emergency first aid capabilities, pre-hospital care, and transportation abilities.
Keywords: Acute myocardial infarction; Acute stroke; Barriers self-transportation; Emergency medical service.
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China has gradually established a clinical medical education system with Chinese characteristics, which includes three stages of medical school, graduate medical education and continuing education, with "5 + 3" model as the main body, 8-year program as the exploration and "3 + 2" model as the supplement [].In a broad sense, there are three types of "5 + 3" model.
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In 2018, China had 420 undergraduate institutions with medical education (excluding military institutions), ma- triculating 286,219 medical undergraduates, 81,128 mas- ters and 14,044 doctors in 2018-2019. The number of higher clinical medicine graduates rose dramatically from 51,800 in 2002, to 182,900 in 2018, with an average annual growth ...
Medical education reforms in China. Julio Frenk and colleagues1 put forward education for life as a guiding principle for health-professional education after the COVID-19 pandemic. We concur with the need for a radical rethink of medical education systems worldwide, and would like to share responses and reflections from China at a time that ...
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Objectives The purpose of this study was to investigate the preferred modes of transportation to the hospital among patients with acute stroke and acute myocardial infarction (AMI), as well as to identify the factors that influence the utilization of ambulances. Methods We conducted a cross-sectional study, including patients who were diagnosed with acute stroke and AMI, at the people's ...
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We interviewed 17 Chinese medical students. When comparing various aspects of the Chinese and American health education and medical systems, most students (91%) thought that China's medical education system placed highest value on textbook learning, and all students (100%) believed self-learning to be most important in the USA.
There is still ambulance underutilization among patients with acute stroke and AMI in county territory of China. Moreover, it is needed to raise the level of first aid education and awareness about EMS. Additionally, private clinic doctors and the public should gain adequate understanding of the sev …