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WRF awards more than $2 million in grants to support the development of plans for life-science initiatives in the state

Investigators at Fred Hutch Cancer Center, the Seattle Hub for Synthetic Biology, the University of Washington and Washington State University will use funding to develop plans for large-scale efforts that can significantly enhance the life-science innovation ecosystem in Washington state

Seattle, WA – May 30, 2024

Washington Research Foundation (WRF) has awarded nearly $2.2 million in new grant funding to researchers at four nonprofit institutions in Washington state. WRF funded 12 teams of investigators at Fred Hutch Cancer Center (Fred Hutch), the Seattle Hub for Synthetic Biology, the University of Washington (UW) and Washington State University (WSU) to develop detailed plans for projects and programs that could significantly advance the state’s life-science ecosystem and improve lives.

WRF concluded an eight-month strategic planning process last year and committed to increasing its support of big, emergent opportunities in the region over the next five years. The call for planning grants was one way to surface ideas for such opportunities. Another program that resulted from the strategic planning process was a call to support IND-enabling and clinical studies for novel therapeutics . Awards made through that program will be announced in the coming weeks.

Over the next 12 to 18 months, each team will use its planning grant to develop a proposal for a large-scale initiative—potentially on a similar scale to the Invent at Seattle Children’s Postdoctoral Scholars Program that WRF has supported since its launch in 2022—for submission to WRF and/or other funding agencies. In its RFP for this award, WRF encouraged investigators to consider elements including potential collaborations between institutions, building diverse, equitable and inclusive innovation ecosystems, and exploring commercialization paths for new technologies to address unmet public needs in the region.

WRF awarded a total of $2,190,486 to support comprehensive planning for the following projects:

  • Jennifer Adair, Ph.D. , will lead the development of a funding proposal for Bridging the Clinical Gap: Adding Value to the “Discovered Here in Washington” Therapeutic Ecosystem at Fred Hutch
  • Joshua Hill, MD , will lead Immunotherapeutic Approaches to Prevent and Treat Infections in Immunocompromised Hosts: The ImmunoPTImize Network at Fred Hutch
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Meher Antia, Ph.D., WRF’s director of grant programs, said that the planning grants are intended to give investigators the time and resources to fully map out ideas for ambitious and achievable high-impact projects that could significantly improve lives in Washington state and beyond.

“We were delighted to see the interest that was generated by our call for creative, collaborative ideas that would spur innovation in Washington,” Antia said. “The planning grants are just the beginning of a process that we hope will result in long-term impact in a broad variety of life science areas.”

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May 28, 2024

Purdue joins Lilly at LEAP in pharmaceutical training facility

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Purdue and Lilly will continue to build upon their collaborative Lilly Scholars program, which helps Boilermaker students earn pharmaceutical manufacturing scholarships and unique learning opportunities at the company. (Purdue for Life Foundation photo/Brayden Williams)

Lilly announced on May 24 its additional investment to the LEAP District, including a new training facility in partnership with Purdue. LEAP is the midpoint along the Hard-Tech Corridor between Purdue's campuses in Indianapolis and West Lafayette.

INDIANAPOLIS — Purdue University is continuing its collaboration with Eli Lilly and Company as the Indianapolis-based pharmaceutical company’s official education partner at Indiana’s LEAP Research and Innovation District. Lilly announced plans to invest another $5.3 billion in its brand-new Boone County manufacturing complex on Friday (May 24), bringing the total investment to $9 billion. LEAP is a key part of the Hard-Tech Corridor from Purdue University’s flagship campus in West Lafayette to the heart of downtown Indianapolis .

Purdue and Lilly will continue to build upon their collaborative scholarship and training program, the Lilly Scholars program , which helps Boilermaker students earn pharmaceutical manufacturing scholarships and unique learning opportunities with Lilly, one of the world’s most innovative pharmaceutical companies. The inaugural Purdue class of Lilly Scholars just completed the 2023-24 academic year. The dynamic program offers 50-100 talented students full tuition with a guaranteed internship at Lilly and a promise of coordinated interaction with company leaders. Participating students will then be provided opportunities to compete for a role at the company following graduation.

As Lilly and Purdue work together on new curricula, experiential learning, and certificate and degree programs in pharmaceutical manufacturing, they will help continue to grow pharmaceutical manufacturing in Indiana and expand Purdue’s talent pipeline to the company with students supported by the scholarship program.

Lilly and Purdue have collaborated on multiple fronts over the years, but especially in 2024. The company’s world headquarters are less than a mile away from the new One Health Innovation District . That partnership between Purdue and Elanco, an animal health leader that was previously a subsidiary of Lilly before being divested, was announced on May 23. In January, Lilly Endowment Inc. approved two grants totaling $100 million to Purdue Research Foundation to support two major Purdue University initiatives — the Mitchell E. Daniels, Jr. School of Business and Purdue Computes — both of which were identified last year by Purdue as top  strategic initiatives  for the university. Together those commitments represented the largest gift in the university’s history.

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Expert Tips on How to Get Good Sleep with Parkinson's

Man sleeping in bed

Sleep recharges our brains and bodies, while boosting mental wellness. People living with Parkinson’s disease (PD) need even more time to reset and restore. Discover how Parkinson’s symptoms, medications or other health problems can impact your sleep, and what you can do to maximize slumber.

This article is based on  Trouble with Zzz's: Sleep Challenges with Parkinson's , a Parkinson’s Foundation  Expert Briefing  webinar presented Aleksandar Videnovic, MD, MSc, associate professor of neurology at Harvard Medical School and director for the Massachusetts General Hospital Division of Sleep Medicine and Program on Sleep, Circadian Biology and Neurodegeneration.

Aging, PD and Trouble with Sleep

As people age, it may be harder to fall asleep and waking up at night can be more frequent. Parkinson’s can further disrupt restorative sleep . As many as 80-90% of people with Parkinson’s can experience a sleep problem during the course of the disease.

Parkinson’s-related brain changes upset the circadian system, sometimes called the body’s internal clock. PD also impacts sleep drive — the growing sensation as day turns to night of the need to sleep. Other elements of PD that can disrupt slumber include:

  • Parkinson's symptoms , such as tremor or PD-related pain , may emerge overnight as medications wear off. Other symptoms include akinesia (difficulty moving or inability to move), rigidity, dyskinesia (erratic, involuntary movement) and more.
  • Medications used to treat PD can interfere with sleep. Others can make it harder to stay alert during the day.
  • Depression and anxiety are extremely common PD symptoms. These and other symptoms, such as hallucinations , can keep a person awake at night.
  • Changes to the autonomic system , the body’s network for regulating jobs like breathing and blood pressure, impact sleep. Nocturia — excessive nighttime urination — can be common in PD.

Sleep disorders can be exhausting for a person with Parkinson’s, as well as their bed partner. These can include:

  • Obstructive sleep apnea and other sleep-disordered breathing can obstruct the airway repeatedly during sleep, resulting in coughing, choking and frequent waking. People with sleep-disordered breathing experience microarousals, waking up to 60 times hourly, without recognizing it. Sleep apnea affects up to 10% of the population, impacting people without Parkinson’s and those with PD with the same frequency.
  • Excessive daytime sleepiness (EDS) may make it difficult to stay awake during daylight hours or cause sudden daytime sleep. PD brain changes and symptoms, medication regimens, co-existent sleep disorders and age-related physical changes can all cause EDS. Up to 16% or more of people with PD may experience poor daytime alertness. Some may be unaware of how EDS affects them. A trusted companion can offer honest input. Sometimes, sleep attacks can come on without any warning, significantly impacting a person’s ability to drive safely .
  • Restless legs syndrome (RLS), an uncomfortable feeling in the legs or feet and irresistible need to move, can impact some people even prior to a PD diagnosis. However, not everyone with Parkinson’s experiences RLS, nor will most people who experience RLS go on to develop PD.
  • Rapid eye movement (REM) sleep behavior disorder (RBD): People dream and experience muscle relaxation during REM stage of sleep. RBD can affect up to half of people with Parkinson’s, impacting muscle relaxation and causing people to act out their dreams — talking, yelling or moving about.

Like restless legs syndrome, RBD can begin long before a Parkinson’s diagnosis. Although not everyone who lives with RBD will develop Parkinson’s, their risk of developing PD or Dementia with Lewy Bodies — diagnosed when cognitive decline happens before or alongside motor symptoms  —  is significantly higher. This is meaningful for Parkinson’s research.

As potential therapies evolve to slow PD progression, there may be a window of opportunity for preventative intervention in people who experience REM sleep behavior disorder but have yet to develop a neurodegenerative disease.

Management Strategies for Fragmented Sleep

Talk to your healthcare provider about sleep issues, fatigue or daytime sleepiness. Your doctor may ask questions about your sleep history. A careful review of each or your medications will help your doctor determine whether a simple adjustment or addition might improve slumber:

  • Long-acting levodopa or additional levodopa is sometimes prescribed for bedtime use.
  • Catechol-O-methyl transferase (COMT) is an enzyme in the body. It can impact the effectiveness of levodopa. COMT inhibitors prolong the benefits of levodopa. These are primarily used for wearing off (changes in the ability to move between doses of levodopa) but are sometimes also prescribed with levodopa for use at night.
  • People taking diuretics might be directed to use them earlier in the day. Likewise, limiting the use of PD medications selegiline and amantadine later in the day might improve insomnia.
  • Anticholinergic medications are sometimes used for nocturia, however, cognitive slowing can be a side effect. These can also cause confusion and hallucinations and are not recommended in older people.
  • Caffeine and some stimulant medications can promote alertness during the day.

Mental wellness: Talk to your doctor about symptoms of depression or other emotional challenges. Parkinson’s impacts areas of the brain that regulate mood, sleep, energy and more. Caring for mental health also benefits sleep.

Sleep disorders : If your doctor suspects a sleep disorder such as obstructed breathing, restless legs or RBD, you might be referred for a sleep study in a sleep clinic.

  • Sleep apnea treatment may require a dental appliance or a continuous positive airway pressure (CPAP) machine that is worn when sleeping or napping.
  • Dopamine agonists — medications that rouse areas of the brain motivated by dopamine — benzodiazepines, opioids and a class of medications known as calcium channel alpha-2 delta ligands, such a gabapentin, are sometimes used for restless legs syndrome. Dopamine-blocking, anticholinergic and antihistamine medications should be avoided for RLS.
  • Your doctor may recommend melatonin or the medication clonazepam for RBD. While antidepressants may help with some aspects of insomnia, some can unmask or worsen RBD.

Tips to Improve Shut-eye

A healthy sleep routine — sometimes called sleep hygiene — is another key component to a good night’s rest. Try these small changes that can make a big difference:

  • Exercise regularly (aim for early in the day) to improve sleep quality and overall function.
  • Limit naps: a short snooze earlier in the day, of 30 minutes or less, is less likely to interfere with nighttime sleep. 
  • Avoid stimulants, such as caffeine, later in the day.
  • Minimize your screen time before bed. Avoid screens entirely — including TV and mobile devices — in the bedroom.
  • Go to sleep and rise at the same time, weekdays and weekends.
  • Turn the lights out: light regulates the body’s clock, signaling that it is time to wake.
  • Employ motion-detecting nightlights to safely guide you to the bathroom.
  • Sleep in a wider bed that is lower to ground. This can minimize injuries and lessen the impact in case of an accidental fall.
  • Consider a bedside rail to prevent falls; a bedside commode can also be helpful for people who have difficulty getting to the toilet at night.
  • Use satin or silk sheets or pajamas to make it easier to turn in bed.

Adequate hydration can improve PD symptoms, boosting low blood pressure and easing constipation. However, drinking liquids too close to bedtime can cause frequent nighttime urination. Minimize beverages a few hours before bed.

Light hitting the eyes is one of the biggest environmental factors regulating the circadian system. The timing of meals, exercise, naps and rest also influences our body clock. In turn, this timer regulates our mood, behavior, immune response and more. Researchers are exploring ways to improving circadian system function in PD.

Light therapy shows great promise as a noninvasive, widely available, nonpharmacological treatment to ease non-movement symptoms of Parkinson’s, including fatigue, sleep issues and mood changes.

In a 2017 JAMA Neurology journal study, Videnovic et al. found that exposure to bright light (10,000 lux) or dim-red light (less than 300 lux) — twice daily in one-hour sessions over two weeks — improved daytime alertness and sleep quality.

Those findings were carried over into the recently completed ENLITE PD trial conducted at 25 sites across North America. The study analyzes the effect of daily light therapy on PD symptoms, including sleep. At the time of this Expert Briefing, the study’s authors were preparing to submit their findings for publication, with the aim of conducting a phase III clinical trial.

To learn more about Parkinson’s and sleep explore these resources:

  • Parkinson’s Disease and Sleep
  • Sleep Disorders
  • Care Partner Deep Dive: Three Experts Discuss Sleep, Cognition and Mood in Parkinson's

Videnovic, A., Klerman, E. B., Wang, W., Marconi, A., Kuhta, T., & Zee, P. C. (2017). Timed light therapy for sleep and daytime sleepiness associated with parkinson disease.  JAMA Neurology ,  74 (4), 411. https://doi.org/10.1001/jamaneurol.2016.5192

Related Materials

Sleep: a mind guide to parkinson's disease, episode 121: parkinson’s disease and sleep, sleep problems in parkinson’s, related blog posts.

Woman sleeping in bed

Sleep and Parkinson’s: Non-Motor Quality of Life

Woman sleeping

7 Tips for Better Sleep

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New Study Examines Impulse Control, REM Sleep and Dopamine

Parkinson's connection, personal information.

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Savvino-storozhevsky monastery and museum.

Savvino-Storozhevsky Monastery and Museum

Zvenigorod's most famous sight is the Savvino-Storozhevsky Monastery, which was founded in 1398 by the monk Savva from the Troitse-Sergieva Lavra, at the invitation and with the support of Prince Yury Dmitrievich of Zvenigorod. Savva was later canonised as St Sabbas (Savva) of Storozhev. The monastery late flourished under the reign of Tsar Alexis, who chose the monastery as his family church and often went on pilgrimage there and made lots of donations to it. Most of the monastery’s buildings date from this time. The monastery is heavily fortified with thick walls and six towers, the most impressive of which is the Krasny Tower which also serves as the eastern entrance. The monastery was closed in 1918 and only reopened in 1995. In 1998 Patriarch Alexius II took part in a service to return the relics of St Sabbas to the monastery. Today the monastery has the status of a stauropegic monastery, which is second in status to a lavra. In addition to being a working monastery, it also holds the Zvenigorod Historical, Architectural and Art Museum.

Belfry and Neighbouring Churches

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Located near the main entrance is the monastery's belfry which is perhaps the calling card of the monastery due to its uniqueness. It was built in the 1650s and the St Sergius of Radonezh’s Church was opened on the middle tier in the mid-17th century, although it was originally dedicated to the Trinity. The belfry's 35-tonne Great Bladgovestny Bell fell in 1941 and was only restored and returned in 2003. Attached to the belfry is a large refectory and the Transfiguration Church, both of which were built on the orders of Tsar Alexis in the 1650s.  

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To the left of the belfry is another, smaller, refectory which is attached to the Trinity Gate-Church, which was also constructed in the 1650s on the orders of Tsar Alexis who made it his own family church. The church is elaborately decorated with colourful trims and underneath the archway is a beautiful 19th century fresco.

Nativity of Virgin Mary Cathedral

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The Nativity of Virgin Mary Cathedral is the oldest building in the monastery and among the oldest buildings in the Moscow Region. It was built between 1404 and 1405 during the lifetime of St Sabbas and using the funds of Prince Yury of Zvenigorod. The white-stone cathedral is a standard four-pillar design with a single golden dome. After the death of St Sabbas he was interred in the cathedral and a new altar dedicated to him was added.

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Under the reign of Tsar Alexis the cathedral was decorated with frescoes by Stepan Ryazanets, some of which remain today. Tsar Alexis also presented the cathedral with a five-tier iconostasis, the top row of icons have been preserved.

Tsaritsa's Chambers

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The Nativity of Virgin Mary Cathedral is located between the Tsaritsa's Chambers of the left and the Palace of Tsar Alexis on the right. The Tsaritsa's Chambers were built in the mid-17th century for the wife of Tsar Alexey - Tsaritsa Maria Ilinichna Miloskavskaya. The design of the building is influenced by the ancient Russian architectural style. Is prettier than the Tsar's chambers opposite, being red in colour with elaborately decorated window frames and entrance.

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At present the Tsaritsa's Chambers houses the Zvenigorod Historical, Architectural and Art Museum. Among its displays is an accurate recreation of the interior of a noble lady's chambers including furniture, decorations and a decorated tiled oven, and an exhibition on the history of Zvenigorod and the monastery.

Palace of Tsar Alexis

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The Palace of Tsar Alexis was built in the 1650s and is now one of the best surviving examples of non-religious architecture of that era. It was built especially for Tsar Alexis who often visited the monastery on religious pilgrimages. Its most striking feature is its pretty row of nine chimney spouts which resemble towers.

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Integrated DNA Technologies Invests in New U.S. Synthetic Biology Manufacturing Facility

CORALVILLE, Iowa (May 28, 2024) –Global genomics solutions provider Integrated DNA Technologies (IDT) today announced the expansion of its synthetic biology operations with the opening of a new 25,000 square-foot-site in Coralville, IA. The two-story building will be dedicated to the manufacturing of IDT synthetic biology products, doubles IDT's synthetic biology footprint, and enables IDT to further enhance its gene synthesis portfolio with differentiated offerings.

"The expansion of our synthetic biology manufacturing operations adds significant capacity for IDT and lays the foundation for the future growth of our synthetic biology product portfolio, says Demaris Mills, President, IDT. "With this increased footprint, we will be introducing new product enhancements, which will include the launch of a rapid gene synthesis offering expected in late Q2. This investment provides IDT with a growth runway for its synthetic biology product portfolio and manufacturing arm to support the rapidly expanding global DNA synthesis market and related drug development activity."

Proximate to IDT's flagship U.S. headquarters, more than half of the 25,000 square-foot facility has been dedicated to synthetic biology lab spaces. Other areas include office and conference rooms, amenities, onsite dedicated support resources, and additional space for future expansion. Notable lab features include enhanced cold storage, facility and flow designed for lean manufacturing, and LED lighting and building automation systems to enable energy efficient building performance. The facility will be operational 24 hours a day, seven days a week.

The investment comes after IDT's recent launch of the new custom vector onboarding tool to equip researchers with an easy-to-use solution that enables them to skip in-house cloning steps and move quickly into functional studies with 100% sequence-verified clonal DNA. The launch was the latest addition to IDT's broad synthetic biology portfolio comprised of gene and gene fragment offerings. As a large-scale provider of synthetic DNA, IDT can make gene fragments between 125 bp to 3 kb, and custom genes from 25 bp to over 5 kb.

The expansion of IDT's synthetic biology manufacturing facility marks the second facility completion for IDT within the last 12 months. In late 2023, IDT announced the completion of its new Therapeutic Oligonucleotide Manufacturing facility in Iowa, which commemorated its entrance into the therapeutics space.

For more than 35 years, Integrated DNA Technologies, Inc. (IDT) has empowered genomics laboratories with an oligonucleotide manufacturing process unlike anyone else in the industry, featuring the most advanced synthesis, modification, purification, and quality control capabilities available. Since its founding in 1987, IDT has progressed from a leading oligo manufacturer to a genomics solutions provider supporting key application areas such as next generation sequencing, CRISPR genome editing, synthetic biology, digital PCR, and RNA interference. IDT manufactures products used by scientists researching many forms of cancer and most inherited and infectious diseases.

Seeking to fulfill its mission of accelerating the pace of genomics, IDT acquired Archer™ NGS Research Assays in December 2022. When combined with its existing solutions, the expanded portfolio helps realize the shared vision of enabling researchers to rapidly move from the lab to life-changing advances.

IDT's infrastructure supports customers around the globe with its manufacturing headquarters situated in Coralville, Iowa, USA, with additional manufacturing sites in San Diego, California, USA; Boulder, Colorado, USA; Research Triangle Park, North Carolina, USA; Ann Arbor, Michigan, USA; Leuven, Belgium; and Singapore.

IDT is proud to be part of Danaher. Danaher's science and technology leadership puts IDT’s solutions at the forefront of the industry, so they can reach more people. Being part of Danaher means we can offer unparalleled breadth and depth of expertise and solutions to our customers.

Together with Danaher's other businesses across Biotechnology, Diagnostics and Life Sciences, we unlock the transformative potential of cutting-edge science and technology to improve billions of lives every day.

For more information about IDT, visit www.idtdna.com  and follow the company on LinkedIn , X , Facebook , YouTube , and Instagram .

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Gino Macchio Foundation’s First Annual Charity Golf Outing is June 4 at Stonebridge Golf Links and Country Club

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The Gino Macchio Foundation’s First Annual “I Got You” Golf Outing to support their Put Recovery to Work Program is happening on June 4 at the Stonebridge Golf Links and Country Club in Smithtown.

The inaugural golf outing will honor Smithtown Town Supervisor Ed Wehrheim for his strong advocacy of the Foundation’s Put Recovery to Work mission. "It has been an absolute joy and privilege to work with the Gino Macchio Foundation on Put Recovery to Work. It is the missing link in helping to achieve an individual's path towards success in sobriety, removing the stigma and giving back purpose to one’s life. I’m deeply humbled to be honored during the inaugural golf outing." - Supervisor Ed Wehrheim

The golf outing which begins at the 11:30am check in, includes grab & go breakfast, BBQ lunch on the patio, snacks and refreshments while on the course, and a buffet dinner with open bar. Tickets and event sponsorships can be purchased at https://givebutter.com/gmfgolfday2024 .

The Gino Macchio Foundation’s Put Recovery to Work program is leading the way on Long Island by providing a boost for people in recovery to attain and maintain employment. Research shows that gainful employment instills meaning into the lives of people in active recovery from substance use disorders, resulting in a higher likelihood of desired outcomes. Businesses benefit with employees who work hard to maintain the trust employers have shown them by hiring them. Dollars raised at the Golf Outing will be used to fund the program’s activities.

These are some of the ways the Foundation supports individuals in recovery:

• Provide employees in recovery financial support and tools to remove barriers to employment. Customized scholarship programs can be used to pay for transportation expenses, clothing, housing, work tools, or other items that affect employment status. • Make a financial contribution to the employer towards the salary of hired individuals in the first year of employment. • Partner with recovery community organizations and other groups who provide treatment to those in recovery.

About the Gino Macchio Foundation: The Gino Macchio Foundation, a 501 ( c ) (3) not-for-profit organization, was formed in 2019 after the death of Gino Macchio in a left-turn motorcycle crash. At that point in time Gino was in active recovery and had successfully turned his life around for the better. Gino paid it forward by helping others who had been in his shoes. Inspired by his life motto: “I Got You,” Gino’s family and friends have taken his dream a step further, empowering individuals in recovery by providing financial and tangible resources to remove barriers to gainful employment and encouraging Long Island based businesses to become recovery-friendly workplaces. For more information visit: www.GinoMacchioFoundation.com or call (631) 496-6179.

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